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PC 707 – 100 Pharmacology Questions on GERD, Ulcers, Nausea, Constipation & DMARDs | Clinical Management

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This document provides 100 high-yield exam questions with answers for the PC 707 Clinical Pharmacology course, focusing on gastrointestinal and inflammatory disorders. It offers an in-depth exploration of drug classes, mechanisms, clinical uses, contraindications, and patient education points for a wide range of conditions, including GERD, peptic ulcer disease (PUD), constipation, diarrhea, nausea, vomiting, irritable bowel syndrome (IBS), and autoimmune diseases treated with DMARDs. Pharmacologic topics include antacids, H2-receptor antagonists, proton pump inhibitors (PPIs), mucosal protectants, osmotic and stimulant laxatives, anti-diarrheals, anti-emetics (including serotonin, dopamine, and NK1 antagonists), herbal and probiotic therapies, and specialty agents such as misoprostol and sucralfate. The content also thoroughly covers treatment in special populations like pregnant and lactating women, children, and the elderly, and includes black box warnings, adverse effects, drug interactions, and evidence-based recommendations. DMARDs (e.g., Humira, Rituximab) are also reviewed for their indications in inflammatory diseases and associated safety concerns. This resource is ideal for advanced practice nursing, DNP, MSN, and PA students, especially those focusing on primary care, gastroenterology, family medicine, women’s health, and internal medicine. It is also highly useful for students preparing for board exams like AANP, ANCC, and PANCE, or seeking a practical review of pharmacologic interventions for GI and immune-related disorders. Keywords: GERD, PUD, constipation, diarrhea, nausea, vomiting, antacids, PPIs, H2 blockers, laxatives, antiemetics, DMARDs, IBS treatment, sucralfate, misoprostol, Reglan, Pepto-Bismol, probiotics, lactulose, metoclopramide, loperamide, ondansetron, Humira, immunosuppressants, black box warning, pharmacology quiz, clinical pharmacology review, PC 707 exam prep

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PC707- Module 3 2025/2026 Exam
Questions and Answers 100%
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Anti-Ulcer drugs help by: - 🧠 ANSWER ✔✔-altering gastric pH by

decreasing acid secretion

-protecting the stomach wall lining by increasing mucosal protection

-eradicating harmful bacteria Ex: H. Pylori

What are the main pharmacologic categories of drugs we used to manage

gastric acid secretion and the effects: - 🧠 ANSWER ✔✔-antacids


-H2 receptor antagonists

-proton pump inhibitors (PPIs)

-prostoglandin analogs

-mucosal protectant sulcrafate (Carafate)

,What is the first OTC medication tried by patients with dyspepsia? - 🧠

ANSWER ✔✔-Antacids




-->these are typically not effective for persistant GERD and PUD


What are antacids? How do they work? - 🧠 ANSWER ✔✔-organic salts


-neutralize the hydrochloric acid in the stomach

-raises the gastric pH above 4.0


What are the main side effects of antacids? - 🧠 ANSWER ✔✔-diarrhea


-constipation


What are the different categories of antacids? - 🧠 ANSWER ✔✔-calcium

carbonate

-sodium bicarbonate

-aluminum based

-magnesium based

-aluminum hydroxide

,What is important teaching for patients taking antacids? - 🧠 ANSWER ✔✔-

decreasing the stomach pH can cause the decrease absorption of drugs

that rely on acidic conditions

-if taking enteric coated medications--reducing stomach acid can cause the

medication to dissolve and absorb in the stomach instead of the intestine

**always separate antacids from other medications by 2 hours**


Calcium carbonate antacids: - 🧠 ANSWER ✔✔-Tums


-can cause CONSTIPATION

-require adequate fluid intake to dissolve

-can be used in patients needing to take an antacid who also could benefit

from extra calcium intake. -potential for milk "alkali" syndrome, metabolic

alkalosis


Sodium Bicarbonate antacids: - 🧠 ANSWER ✔✔-Alka Seltzer


-contains aspirin (ASA)

-potential to WORSEN GI distress. -increased risk for water retention and

fluid overload

-potential to cause hypertension


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, -Contraindicated in pregnancy, children, patient with CVD*


Aluminum based antacids: - 🧠 ANSWER ✔✔-Amphogel


-can cause CONSTIPATION

-requires adequate fluid intake to dissolve

-Contraindicated in patients with renal insufficiency*


Magnesium based antacids: - 🧠 ANSWER ✔✔-Milk of magnesia


-suspension mixture is more effective

-can cause DIARRHEA

-Contraindicated in renal insufficiency*


Aluminum hydroxide antacids: - 🧠 ANSWER ✔✔-may decrease the

absorption of warfarin*. -can cause a chelating affect with drugs such as

tetracyclines, warfarin, and digoxin—potentially decreasing their absorption

& effectiveness -high affinity for phosphate—may cause hypophasphatemia


What can cause heartburn in pregnancy? - 🧠 ANSWER ✔✔-hormonal

fluctuations

-anatomic changes
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