Hydrolysis
Amides Acid :
* produces carboxylic acid + ammonium Saint dilute acid
General
☒ functional group .
-
CONTI ,
CHIH ,
CON Hzt Hat 1-110 → CH , CH , COO Ht NH act
* named after corresponding carboxylic acid
e. g. ethanol acid :
ethan amide Alkali :
* substituents present =
no .
relative to C. in amide * produces salt of carboxylic acid 1- ammonia gas
group *
A methanol Mide liquid at room temp ( H > CONTI , + NaOH > CHINNA + NH }
* rest of straight chain = solids IV
* can be used as test for amide
glass rod in conc .
HCl
Preparation
Dehydration
1) Rxn of acyl chloride w/ amine
* dehydrated by distilling over phosphorous IV ) oxide
* will react to form N substituted amide
-
forming nitrites lfunc group
.
-
C : N )
CH , COCI t CH> ( th Nth SH , C -
É É
- -
Ctlz
-
ctkttlcl CH , CHICO NH ,
Patio
911-13 CHIC : N t tho
ethanoyl ethyl amine N -
ethyl Ethan amide
chloride
Basicity
2) Rxn of carboxylic acid w/ ammonia * compared to amines , very weak bases
* forms ammonium salt t heated dehydrates → amide A lone pair of e- on N atom or amide become
delocalised due to e- withdrawing nature of
CH } 1001-1 1- Ntl , → CH } 100N Hi ,
adjacent 1=0 10 more electro -
re than N)
ammonium lthanoater 4> lone pair not available to form co ord
-
On heating : →
presence of excess NH } to prevent reversing bond WI Ht ions
( H > FOON Hu → CH , 10N Hit 1-120
ethan amide
Amides Acid :
* produces carboxylic acid + ammonium Saint dilute acid
General
☒ functional group .
-
CONTI ,
CHIH ,
CON Hzt Hat 1-110 → CH , CH , COO Ht NH act
* named after corresponding carboxylic acid
e. g. ethanol acid :
ethan amide Alkali :
* substituents present =
no .
relative to C. in amide * produces salt of carboxylic acid 1- ammonia gas
group *
A methanol Mide liquid at room temp ( H > CONTI , + NaOH > CHINNA + NH }
* rest of straight chain = solids IV
* can be used as test for amide
glass rod in conc .
HCl
Preparation
Dehydration
1) Rxn of acyl chloride w/ amine
* dehydrated by distilling over phosphorous IV ) oxide
* will react to form N substituted amide
-
forming nitrites lfunc group
.
-
C : N )
CH , COCI t CH> ( th Nth SH , C -
É É
- -
Ctlz
-
ctkttlcl CH , CHICO NH ,
Patio
911-13 CHIC : N t tho
ethanoyl ethyl amine N -
ethyl Ethan amide
chloride
Basicity
2) Rxn of carboxylic acid w/ ammonia * compared to amines , very weak bases
* forms ammonium salt t heated dehydrates → amide A lone pair of e- on N atom or amide become
delocalised due to e- withdrawing nature of
CH } 1001-1 1- Ntl , → CH } 100N Hi ,
adjacent 1=0 10 more electro -
re than N)
ammonium lthanoater 4> lone pair not available to form co ord
-
On heating : →
presence of excess NH } to prevent reversing bond WI Ht ions
( H > FOON Hu → CH , 10N Hit 1-120
ethan amide
