,Third Edition
Edited by
Curtis R. Chong, MD, PhD, MPHIL, FACP
Stanford University School of Medicine
Palo Alto, California
Massachusetts General Hospital Internal
Medicine Residency Class of 2011
AL GRAWANY
,Acquisitions Editor: Joe Cho
Development Editors: Thomas, Celona, Ashley Fischer
Editorial Coordinators: Christopher Rodgers, Vinodhini Varadharajalu
Marketing Manager: Kirsten Watrud
Production Project Manager: Bridgett Dougherty
Manager, Graphic Arts & Design: Stephen Druding
Manufacturing Coordinator: Beth Welsh
Prepress Vendor: Aptara, Inc.
Third Edition
Copyright © 2023 Wolters Kluwer.
Copyright © 2018 Wolters Kluwer.
© 2014 by LIPPINCOTT WILLIAMS & WILKINS, a WOLTERS KLUWER business
Two Commerce Square
2001 Market Street
Philadelphia, PA 19103 USA
LWW.com
All rights reserved. This book is protected by copyright. No part of this book may be reproduced or
transmitted in any form or by any means, including as photocopies or scanned-in or other electronic
copies, or utilized by any information storage and retrieval system without written permission from
the copyright owner, except for brief quotations embodied in critical articles and reviews. Materials
appearing in this book prepared by individuals as part of their official duties as U.S. government
employees are not covered by the above-mentioned copyright. To request permission, please contact
Wolters Kluwer at Two Commerce Square, 2001 Market Street, Philadelphia, PA 19103, via email at
, or via our website at shop.lww.com (products and services).
987654321
Printed in China
978-1-9751-8358-5
Library of Congress Cataloging-in-Publication Data
available upon request
Library of Congress Control Number: 2022912958
This work is provided “as is,” and the publisher disclaims any and all warranties, express or implied,
including any warranties as to accuracy, comprehensiveness, or currency of the content of this work.
This work is no substitute for individual patient assessment based upon healthcare professionals’
examination of each patient and consideration of, among other things, age, weight, gender, current or
prior medical conditions, medication history, laboratory data and other factors unique to the patient.
The publisher does not provide medical advice or guidance and this work is merely a reference tool.
Healthcare professionals, and not the publisher, are solely responsible for the use of this work
including all medical judgments and for any resulting diagnosis and treatments.
, Given continuous, rapid advances in medical science and health information, independent
professional verification of medical diagnoses, indications, appropriate pharmaceutical selections and
dosages, and treatment options should be made and healthcare professionals should consult a variety
of sources. When prescribing medication, healthcare professionals are advised to consult the product
information sheet (the manufacturer’s package insert) accompanying each drug to verify, among
other things, conditions of use, warnings and side effects and identify any changes in dosage
schedule or contraindications, particularly if the medication to be administered is new, infrequently
used or has a narrow therapeutic range. To the maximum extent permitted under applicable law, no
responsibility is assumed by the publisher for any injury and/or damage to persons or property, as a
matter of products liability, negligence law or otherwise, or from any reference to or use by any
person of this work.
shop.lww.com
AL GRAWANY
Edited by
Curtis R. Chong, MD, PhD, MPHIL, FACP
Stanford University School of Medicine
Palo Alto, California
Massachusetts General Hospital Internal
Medicine Residency Class of 2011
AL GRAWANY
,Acquisitions Editor: Joe Cho
Development Editors: Thomas, Celona, Ashley Fischer
Editorial Coordinators: Christopher Rodgers, Vinodhini Varadharajalu
Marketing Manager: Kirsten Watrud
Production Project Manager: Bridgett Dougherty
Manager, Graphic Arts & Design: Stephen Druding
Manufacturing Coordinator: Beth Welsh
Prepress Vendor: Aptara, Inc.
Third Edition
Copyright © 2023 Wolters Kluwer.
Copyright © 2018 Wolters Kluwer.
© 2014 by LIPPINCOTT WILLIAMS & WILKINS, a WOLTERS KLUWER business
Two Commerce Square
2001 Market Street
Philadelphia, PA 19103 USA
LWW.com
All rights reserved. This book is protected by copyright. No part of this book may be reproduced or
transmitted in any form or by any means, including as photocopies or scanned-in or other electronic
copies, or utilized by any information storage and retrieval system without written permission from
the copyright owner, except for brief quotations embodied in critical articles and reviews. Materials
appearing in this book prepared by individuals as part of their official duties as U.S. government
employees are not covered by the above-mentioned copyright. To request permission, please contact
Wolters Kluwer at Two Commerce Square, 2001 Market Street, Philadelphia, PA 19103, via email at
, or via our website at shop.lww.com (products and services).
987654321
Printed in China
978-1-9751-8358-5
Library of Congress Cataloging-in-Publication Data
available upon request
Library of Congress Control Number: 2022912958
This work is provided “as is,” and the publisher disclaims any and all warranties, express or implied,
including any warranties as to accuracy, comprehensiveness, or currency of the content of this work.
This work is no substitute for individual patient assessment based upon healthcare professionals’
examination of each patient and consideration of, among other things, age, weight, gender, current or
prior medical conditions, medication history, laboratory data and other factors unique to the patient.
The publisher does not provide medical advice or guidance and this work is merely a reference tool.
Healthcare professionals, and not the publisher, are solely responsible for the use of this work
including all medical judgments and for any resulting diagnosis and treatments.
, Given continuous, rapid advances in medical science and health information, independent
professional verification of medical diagnoses, indications, appropriate pharmaceutical selections and
dosages, and treatment options should be made and healthcare professionals should consult a variety
of sources. When prescribing medication, healthcare professionals are advised to consult the product
information sheet (the manufacturer’s package insert) accompanying each drug to verify, among
other things, conditions of use, warnings and side effects and identify any changes in dosage
schedule or contraindications, particularly if the medication to be administered is new, infrequently
used or has a narrow therapeutic range. To the maximum extent permitted under applicable law, no
responsibility is assumed by the publisher for any injury and/or damage to persons or property, as a
matter of products liability, negligence law or otherwise, or from any reference to or use by any
person of this work.
shop.lww.com
AL GRAWANY
