NCLEX/HESI NURSING IN ONCOLOGY EXAM
TEST BANK LATEST 2025 ACTUAL EXAM
WITH MULTIPLE CHOICES AND CORRECT
DETAILED ANSWERS 100+
GRADE A+++++++++ (MORE
DISTINCT
NURSING
NURSING IN ONCOLOGY
,Oncology Nursing — 100 Multiple-Choice Questions (single long list)
Below are 100 oncology nursing MCQs with the correct answer and a brief rationale after each
item. Good luck studying — feel free to ask for a printable PDF or a spaced-practice version
later!
1. Which cell type is primarily responsible for metastasis to bone in breast cancer?
A. Lymphocytes
B. Osteoclasts activated by tumor cells
C. Erythrocytes
D. Platelets
Answer: B.
Rationale: Breast cancer cells stimulate osteoclasts, causing bone resorption and
metastases.
2. The most common side effect of external beam radiation to the head and neck is:
A. Cardiotoxicity
B. Mucositis and xerostomia
C. Nephrotoxicity
D. Peripheral neuropathy
Answer: B.
Rationale: Radiation to head/neck often damages salivary glands and mucosa.
3. A neutropenic patient develops a fever of 38.2°C (100.8°F). The nurse should:
A. Observe and recheck in 12 hours
B. Report immediately and prepare for empiric antibiotics
C. Give acetaminophen only
D. Encourage fluids and rest at home
Answer: B.
Rationale: Fever in neutropenia is an oncologic emergency; prompt evaluation and
antibiotics are required.
4. Which antiemetic class is first-line for acute chemo-induced nausea/vomiting?
A. Benzodiazepines
B. 5-HT3 antagonists (e.g., ondansetron)
C. Opioids
D. Proton pump inhibitors
Answer: B.
Rationale: 5-HT3 antagonists are effective for acute CINV.
, 5. A patient receiving cisplatin should be closely monitored for:
A. Pulmonary fibrosis
B. Ototoxicity and nephrotoxicity
C. Hyperglycemia
D. Cardiac arrhythmias
Answer: B.
Rationale: Cisplatin commonly causes ototoxicity and renal damage.
6. Tumor lysis syndrome is characterized by all EXCEPT:
A. Hyperkalemia
B. Hyperphosphatemia
C. Hypouricemia
D. Hypocalcemia
Answer: C.
Rationale: Tumor lysis causes hyperuricemia, not hypouricemia.
7. The best way to reduce mucositis in a patient receiving chemotherapy is:
A. Frequent alcohol mouthwashes
B. Gentle oral care with non-alcohol rinses and soft brushes
C. Avoiding oral care to reduce trauma
D. High-acid foods to cleanse the mouth
Answer: B.
Rationale: Gentle oral hygiene reduces infection/trauma and helps healing.
8. A patient with thrombocytopenia (platelets 15,000/µL) should avoid:
A. Walking
B. Soft toothbrush use
C. IM injections and NSAIDs
D. Oral fluids
Answer: C.
Rationale: Low platelets increase bleeding risk — avoid IM injections and NSAIDs.
9. Which tumor marker is commonly elevated in prostate cancer?
A. CA-125
B. CEA
C. PSA
D. AFP
Answer: C.
Rationale: Prostate-specific antigen (PSA) is used in prostate cancer
screening/monitoring.
TEST BANK LATEST 2025 ACTUAL EXAM
WITH MULTIPLE CHOICES AND CORRECT
DETAILED ANSWERS 100+
GRADE A+++++++++ (MORE
DISTINCT
NURSING
NURSING IN ONCOLOGY
,Oncology Nursing — 100 Multiple-Choice Questions (single long list)
Below are 100 oncology nursing MCQs with the correct answer and a brief rationale after each
item. Good luck studying — feel free to ask for a printable PDF or a spaced-practice version
later!
1. Which cell type is primarily responsible for metastasis to bone in breast cancer?
A. Lymphocytes
B. Osteoclasts activated by tumor cells
C. Erythrocytes
D. Platelets
Answer: B.
Rationale: Breast cancer cells stimulate osteoclasts, causing bone resorption and
metastases.
2. The most common side effect of external beam radiation to the head and neck is:
A. Cardiotoxicity
B. Mucositis and xerostomia
C. Nephrotoxicity
D. Peripheral neuropathy
Answer: B.
Rationale: Radiation to head/neck often damages salivary glands and mucosa.
3. A neutropenic patient develops a fever of 38.2°C (100.8°F). The nurse should:
A. Observe and recheck in 12 hours
B. Report immediately and prepare for empiric antibiotics
C. Give acetaminophen only
D. Encourage fluids and rest at home
Answer: B.
Rationale: Fever in neutropenia is an oncologic emergency; prompt evaluation and
antibiotics are required.
4. Which antiemetic class is first-line for acute chemo-induced nausea/vomiting?
A. Benzodiazepines
B. 5-HT3 antagonists (e.g., ondansetron)
C. Opioids
D. Proton pump inhibitors
Answer: B.
Rationale: 5-HT3 antagonists are effective for acute CINV.
, 5. A patient receiving cisplatin should be closely monitored for:
A. Pulmonary fibrosis
B. Ototoxicity and nephrotoxicity
C. Hyperglycemia
D. Cardiac arrhythmias
Answer: B.
Rationale: Cisplatin commonly causes ototoxicity and renal damage.
6. Tumor lysis syndrome is characterized by all EXCEPT:
A. Hyperkalemia
B. Hyperphosphatemia
C. Hypouricemia
D. Hypocalcemia
Answer: C.
Rationale: Tumor lysis causes hyperuricemia, not hypouricemia.
7. The best way to reduce mucositis in a patient receiving chemotherapy is:
A. Frequent alcohol mouthwashes
B. Gentle oral care with non-alcohol rinses and soft brushes
C. Avoiding oral care to reduce trauma
D. High-acid foods to cleanse the mouth
Answer: B.
Rationale: Gentle oral hygiene reduces infection/trauma and helps healing.
8. A patient with thrombocytopenia (platelets 15,000/µL) should avoid:
A. Walking
B. Soft toothbrush use
C. IM injections and NSAIDs
D. Oral fluids
Answer: C.
Rationale: Low platelets increase bleeding risk — avoid IM injections and NSAIDs.
9. Which tumor marker is commonly elevated in prostate cancer?
A. CA-125
B. CEA
C. PSA
D. AFP
Answer: C.
Rationale: Prostate-specific antigen (PSA) is used in prostate cancer
screening/monitoring.
