RECOMBINANT DNA 202
DEOXYRIBONUCLEIC ACID STRUCTUR
Dr Danisile Tembe,
SLS Room 05-105,
Tel: 031 260 7586,
Email:
, DNA?
➢DNA is a genetic molecule that store and transmit
genetic information
➢ Made of polynucleotide covalently joined through 3’-5’
–phosphodiester bonds.
, DNA DISCOVERY
➢ First identified in the late 1860s by Swiss chemist
Friedrich Miescher
• Isolates DNA from Salmon sperm
➢ Several scientists carried out a series of research
efforts
• Revealed additional details about the DNA
➢ 1944, Avery, MacLeod and McCarty discovered
• DNA could transform from pathogenic bacteria
to non pathogenic
, DNA DISCOVERY
➢ Hershey and Chase showed that DNA was a
genetic material
➢ In 1953,
• Watson and Crick proposed a structure for DNA
• Following a DNA x-ray image by Rosalind
Franklin
DEOXYRIBONUCLEIC ACID STRUCTUR
Dr Danisile Tembe,
SLS Room 05-105,
Tel: 031 260 7586,
Email:
, DNA?
➢DNA is a genetic molecule that store and transmit
genetic information
➢ Made of polynucleotide covalently joined through 3’-5’
–phosphodiester bonds.
, DNA DISCOVERY
➢ First identified in the late 1860s by Swiss chemist
Friedrich Miescher
• Isolates DNA from Salmon sperm
➢ Several scientists carried out a series of research
efforts
• Revealed additional details about the DNA
➢ 1944, Avery, MacLeod and McCarty discovered
• DNA could transform from pathogenic bacteria
to non pathogenic
, DNA DISCOVERY
➢ Hershey and Chase showed that DNA was a
genetic material
➢ In 1953,
• Watson and Crick proposed a structure for DNA
• Following a DNA x-ray image by Rosalind
Franklin
