BCH 403 – CUMULATIVE FINAL EXAM
QUESTIONS WITH COMPLETE
SOLUTIONS
Which one of the following lipases is capable of cleaving all 3 fatty acids off of
triacylglycerol?
A. Salivary lipase
B. Pancreatic lipase
C. Hormone sensitive lipase
D. Lipoprotein lipase
E. Adipose triglyceride lipase - Answer- D. Lipoprotein lipase
How many FADH2 and NADH is/are generated per cycle of β-oxidation, assuming a
saturated fatty acid? Do not include NADH and FADH2 generated from acetyl-CoA
entering TCA cycle.
A. 2 FADH2
B. 2 NADH
C. 1 FADH2 and 1 NADH
D. 2 FADH2 and 2 NADH
E. 2 FADH2 and 4 NADH - Answer- C. 1 FADH2 and 1 NADH
The regulated step of β-oxidation is
A. Carnitine acyltransferase II
B. Carnitine acyltransferase I
C. Carnitine acylcarnitine translocase
D. Acyl-CoA dehydrogenase
E. Thiolase - Answer- B. Carnitine acyltransferase I
Acetyl-CoA carboxylase is inactivated in the presence of:
A. Citrate
B. Insulin
C. Glucagon
D. Malonyl-CoA
E. Acetyl-CoA - Answer- C. Glucagon
The pathway that detoxifies excess acetyl-CoA is:
A. Ketogenesis
B. Fatty acid biosynthesis
C. Cholesterol biosynthesis
D. β-oxidation
E. TCA cycle - Answer- A. Ketogenesis
,The regulated enzyme in triacylglycerol synthesis is:
A. 1-acylglycerol-3-phoshate acyltransferase
B. Glycerol-3-phosphate acyltransferase
C. Glycerol-3-phosphate-3-dehydrogenase
D. Phosphofructokinase-1
E. Glycerol kinase - Answer- B. Glycerol-3-phosphate acyltransferase
How many high energy phosphate bonds are cleaved during the synthesis of
phosphatidylserine?
A. 3
B. 4
C. 5
D. 1
E. 2 - Answer- E. 2
The following molecule is an example of ____________ ?
A. Cholesterol
B. Vitamin D
C. Steroid hormone
D. Bile
E. Cholesterol ester - Answer- A. Cholesterol
Which one of the following vitamins is NOT lipid soluble?
A. A
B. B
C. D
D. E
E. K - Answer- B. B
Non-skeletal muscle cells transport ____________ to the liver for the detoxification of
ammonia?
A. Alanine
B. Glutamine
C. Glutamate
D. Aspartate
E. Asparagine - Answer- B. Glutamine
Which one of the following amino acids is not involved in one carbon metabolism (or
single carbon metabolism)?
A. Methionine
B. Serine
C. Glycine
D. Alanine - Answer- D. Alanine
Which one of the following amino acids can be synthesized using a transaminase?
A. Alanine
, B. Glutamine
C. Asparagine
D. Isoleucine
E. Leucine - Answer- A. Alanine
How many high energy phosphate bonds are cleaved during the synthesis of 1
molecule of urea?
A. 1
B. 2
C. 3
D. 4
E. 5 - Answer- D. 4
Which one of the following tissues does not use β-oxidation to derive energy?
A. Liver
B. Adipose
C. Skeletal muscle
D. Cardiac
E. Brain - Answer- E. Brain
Which of the following statements is INCORRECT regarding glucagon and epinephrine?
A. Both hormones activate fat mobilization in adipose
B. Both hormones activate gluconeogenesis in the liver
C. Both hormones shut off glycolysis in the liver
D. Both hormones shut off glycolysis in the skeletal muscles - Answer- D. Both
hormones shut off glycolysis in the skeletal muscles
Which of the following is not a result of starvation?
A. Low glucose concentration in bloodstream
B. Significant increase in ketone body production
C. Significant increase in protein degradation in skeletal muscles
D. Increased fatty acid concentrations in bloodstream
E. Synthesis of triacylglycerol in liver - Answer- E. Synthesis of triacylglycerol in liver
Which of the following statements is INCORRECT regarding hormones?
A. Usually exert a short-term effect
B. They are relatively small signaling molecules
C. They can bind to a cell surface or within a cell
D. Secretions of hormones are ultimately controlled by the central nervous system
E. They always directly exert their effect on enzymes - Answer- E. They always directly
exert their effect on enzymes
Which one of the following pathways does not start from acetyl-CoA?
A. Cholesterol biosynthesis
B. Ketogenesis
C. Fatty acid biosynthesis
QUESTIONS WITH COMPLETE
SOLUTIONS
Which one of the following lipases is capable of cleaving all 3 fatty acids off of
triacylglycerol?
A. Salivary lipase
B. Pancreatic lipase
C. Hormone sensitive lipase
D. Lipoprotein lipase
E. Adipose triglyceride lipase - Answer- D. Lipoprotein lipase
How many FADH2 and NADH is/are generated per cycle of β-oxidation, assuming a
saturated fatty acid? Do not include NADH and FADH2 generated from acetyl-CoA
entering TCA cycle.
A. 2 FADH2
B. 2 NADH
C. 1 FADH2 and 1 NADH
D. 2 FADH2 and 2 NADH
E. 2 FADH2 and 4 NADH - Answer- C. 1 FADH2 and 1 NADH
The regulated step of β-oxidation is
A. Carnitine acyltransferase II
B. Carnitine acyltransferase I
C. Carnitine acylcarnitine translocase
D. Acyl-CoA dehydrogenase
E. Thiolase - Answer- B. Carnitine acyltransferase I
Acetyl-CoA carboxylase is inactivated in the presence of:
A. Citrate
B. Insulin
C. Glucagon
D. Malonyl-CoA
E. Acetyl-CoA - Answer- C. Glucagon
The pathway that detoxifies excess acetyl-CoA is:
A. Ketogenesis
B. Fatty acid biosynthesis
C. Cholesterol biosynthesis
D. β-oxidation
E. TCA cycle - Answer- A. Ketogenesis
,The regulated enzyme in triacylglycerol synthesis is:
A. 1-acylglycerol-3-phoshate acyltransferase
B. Glycerol-3-phosphate acyltransferase
C. Glycerol-3-phosphate-3-dehydrogenase
D. Phosphofructokinase-1
E. Glycerol kinase - Answer- B. Glycerol-3-phosphate acyltransferase
How many high energy phosphate bonds are cleaved during the synthesis of
phosphatidylserine?
A. 3
B. 4
C. 5
D. 1
E. 2 - Answer- E. 2
The following molecule is an example of ____________ ?
A. Cholesterol
B. Vitamin D
C. Steroid hormone
D. Bile
E. Cholesterol ester - Answer- A. Cholesterol
Which one of the following vitamins is NOT lipid soluble?
A. A
B. B
C. D
D. E
E. K - Answer- B. B
Non-skeletal muscle cells transport ____________ to the liver for the detoxification of
ammonia?
A. Alanine
B. Glutamine
C. Glutamate
D. Aspartate
E. Asparagine - Answer- B. Glutamine
Which one of the following amino acids is not involved in one carbon metabolism (or
single carbon metabolism)?
A. Methionine
B. Serine
C. Glycine
D. Alanine - Answer- D. Alanine
Which one of the following amino acids can be synthesized using a transaminase?
A. Alanine
, B. Glutamine
C. Asparagine
D. Isoleucine
E. Leucine - Answer- A. Alanine
How many high energy phosphate bonds are cleaved during the synthesis of 1
molecule of urea?
A. 1
B. 2
C. 3
D. 4
E. 5 - Answer- D. 4
Which one of the following tissues does not use β-oxidation to derive energy?
A. Liver
B. Adipose
C. Skeletal muscle
D. Cardiac
E. Brain - Answer- E. Brain
Which of the following statements is INCORRECT regarding glucagon and epinephrine?
A. Both hormones activate fat mobilization in adipose
B. Both hormones activate gluconeogenesis in the liver
C. Both hormones shut off glycolysis in the liver
D. Both hormones shut off glycolysis in the skeletal muscles - Answer- D. Both
hormones shut off glycolysis in the skeletal muscles
Which of the following is not a result of starvation?
A. Low glucose concentration in bloodstream
B. Significant increase in ketone body production
C. Significant increase in protein degradation in skeletal muscles
D. Increased fatty acid concentrations in bloodstream
E. Synthesis of triacylglycerol in liver - Answer- E. Synthesis of triacylglycerol in liver
Which of the following statements is INCORRECT regarding hormones?
A. Usually exert a short-term effect
B. They are relatively small signaling molecules
C. They can bind to a cell surface or within a cell
D. Secretions of hormones are ultimately controlled by the central nervous system
E. They always directly exert their effect on enzymes - Answer- E. They always directly
exert their effect on enzymes
Which one of the following pathways does not start from acetyl-CoA?
A. Cholesterol biosynthesis
B. Ketogenesis
C. Fatty acid biosynthesis
