Chapter 17: Immune Disorders, Tools, and Vaccines
MULTIPLE CHOICE
1. An example of a primary immunodeficiency would be
a. DiGeorge syndrome.
b. HIV.
c. severe combined immunodeficiency syndrome.
d. IgA deficiency.
ANS: A DIF: Moderate REF: 17.1
OBJ: 17.1a Distinguish primary and secondary immunodeficiencies.
MSC: Understanding
2. All of the following are consequences of bare lymphocyte syndrome (MHC II deficiency) EXCEPT
a. the MHC II molecule is expressed on APCs.
b. T cells will not form into TH1, TH2, or other types of helper T cells.
c. cytotoxic T cells cannot be activated.
d. B cells do not isotype switch.
ANS: A DIF: Difficult REF: 17.1
OBJ: 17.1b Describe the common forms of severe combined immunodeficiencies.
MSC: Analyzing
3. Which of the following is true regarding T-cell deficiencies?
a. A mutation in the IL-2 receptor affects T-cell proliferation.
b. A deficiency in ATP causes apoptosis in T, B, or NK cells.
c. Immunoglobulin protection is permanent.
d. Severe combined immunodeficiencies (SCIDs) are characterized by a lack of B cells.
ANS: A DIF: Moderate REF: 17.1
OBJ: 17.1b Describe the common forms of severe combined immunodeficiencies.
MSC: Understanding
4. All of the following are examples of B-cell disorders EXCEPT
a. X-linked agammaglobulinemia (Burton’s disease).
b. common variable immunodeficiency (CVID).
c. DiGeorge syndrome.
d. selective IgA deficiency.
ANS: C DIF: Moderate REF: 17.1
OBJ: 17.1c Compare the underlying defects and outcomes of bare lymphocyte syndrome, X-linked
agammaglobulinemia, hyper IgM syndrome, selective IgA deficiency, and complement deficiencies.
MSC: Analyzing
5. Complement deficiencies are
a. acquired during life. c. inherited autosomal traits.
b. X-linked. d. treated with antivirals.
ANS: C DIF: Easy REF: 17.1
, OBJ: 17.1c Compare the underlying defects and outcomes of bare lymphocyte syndrome, X-linked
agammaglobulinemia, hyper IgM syndrome, selective IgA deficiency, and complement deficiencies.
MSC: Remembering
6. How does immune surveillance work inside the host?
a. Cancer cells are sought out but not destroyed.
b. The immune system is suppressed.
c. Immune cells are unable to recognize cancerous cells.
d. Cancer cells are marked with surface antigens not present on normal cells.
ANS: D DIF: Moderate REF: 17.2
OBJ: 17.2a Discuss the relationship between our immune system and cancer.
MSC: Applying
7. Patients with primary immunodeficiencies and who are immunosuppressed are prone to developing
cancers. Which is the most commonly developed cancer for these patients?
a. Epstein-Barr c. myelomas
b. B-cell lymphomas d. mononucleosis
ANS: B DIF: Difficult REF: 17.2
OBJ: 17.2a Discuss the relationship between our immune system and cancer.
MSC: Applying
8. Leukemia refers to
a. a malignant lymphoid cell found in circulation or bone marrow.
b. a solid mass in a lymphoid organ.
c. growth of a plasma cell.
d. cancerous plasma cells that appear at multiple sites.
ANS: A DIF: Easy REF: 17.2
OBJ: 17.2b Distinguish lymphoma, leukemia, plasmocytoma, and multiple myeloma.
MSC: Remembering
9. All of the following are true about Hodgkin’s lymphoma EXCEPT that
a. it is often caused by the herpes simplex virus.
b. symptoms include fever, night sweats, and weight loss.
c. tumors contain neoplastic, multinucleated Reed-Sternberg cells.
d. the release of cytokines such as TNF-alpha contributes to the fever and chronic
inflammation.
ANS: A DIF: Difficult REF: 17.2
OBJ: 17.2c Explain the defects leading to B-cell neoplasms. MSC: Analyzing
10. All of the following are true about B-cell neoplasms EXCEPT
a. cancers arise in B cells when genes that control cell division are dysregulated and fail to
replicate.
b. follicular lymphoma occurs when the bcl-2 gene is activated and prevents apoptosis.
c. chronic lymphocytic leukemia occurs when there is a deletion in chromosome 13.
d. Burkitt’s lymphoma develops when the c-myo gene moves next to expressed antibody
genes.
MULTIPLE CHOICE
1. An example of a primary immunodeficiency would be
a. DiGeorge syndrome.
b. HIV.
c. severe combined immunodeficiency syndrome.
d. IgA deficiency.
ANS: A DIF: Moderate REF: 17.1
OBJ: 17.1a Distinguish primary and secondary immunodeficiencies.
MSC: Understanding
2. All of the following are consequences of bare lymphocyte syndrome (MHC II deficiency) EXCEPT
a. the MHC II molecule is expressed on APCs.
b. T cells will not form into TH1, TH2, or other types of helper T cells.
c. cytotoxic T cells cannot be activated.
d. B cells do not isotype switch.
ANS: A DIF: Difficult REF: 17.1
OBJ: 17.1b Describe the common forms of severe combined immunodeficiencies.
MSC: Analyzing
3. Which of the following is true regarding T-cell deficiencies?
a. A mutation in the IL-2 receptor affects T-cell proliferation.
b. A deficiency in ATP causes apoptosis in T, B, or NK cells.
c. Immunoglobulin protection is permanent.
d. Severe combined immunodeficiencies (SCIDs) are characterized by a lack of B cells.
ANS: A DIF: Moderate REF: 17.1
OBJ: 17.1b Describe the common forms of severe combined immunodeficiencies.
MSC: Understanding
4. All of the following are examples of B-cell disorders EXCEPT
a. X-linked agammaglobulinemia (Burton’s disease).
b. common variable immunodeficiency (CVID).
c. DiGeorge syndrome.
d. selective IgA deficiency.
ANS: C DIF: Moderate REF: 17.1
OBJ: 17.1c Compare the underlying defects and outcomes of bare lymphocyte syndrome, X-linked
agammaglobulinemia, hyper IgM syndrome, selective IgA deficiency, and complement deficiencies.
MSC: Analyzing
5. Complement deficiencies are
a. acquired during life. c. inherited autosomal traits.
b. X-linked. d. treated with antivirals.
ANS: C DIF: Easy REF: 17.1
, OBJ: 17.1c Compare the underlying defects and outcomes of bare lymphocyte syndrome, X-linked
agammaglobulinemia, hyper IgM syndrome, selective IgA deficiency, and complement deficiencies.
MSC: Remembering
6. How does immune surveillance work inside the host?
a. Cancer cells are sought out but not destroyed.
b. The immune system is suppressed.
c. Immune cells are unable to recognize cancerous cells.
d. Cancer cells are marked with surface antigens not present on normal cells.
ANS: D DIF: Moderate REF: 17.2
OBJ: 17.2a Discuss the relationship between our immune system and cancer.
MSC: Applying
7. Patients with primary immunodeficiencies and who are immunosuppressed are prone to developing
cancers. Which is the most commonly developed cancer for these patients?
a. Epstein-Barr c. myelomas
b. B-cell lymphomas d. mononucleosis
ANS: B DIF: Difficult REF: 17.2
OBJ: 17.2a Discuss the relationship between our immune system and cancer.
MSC: Applying
8. Leukemia refers to
a. a malignant lymphoid cell found in circulation or bone marrow.
b. a solid mass in a lymphoid organ.
c. growth of a plasma cell.
d. cancerous plasma cells that appear at multiple sites.
ANS: A DIF: Easy REF: 17.2
OBJ: 17.2b Distinguish lymphoma, leukemia, plasmocytoma, and multiple myeloma.
MSC: Remembering
9. All of the following are true about Hodgkin’s lymphoma EXCEPT that
a. it is often caused by the herpes simplex virus.
b. symptoms include fever, night sweats, and weight loss.
c. tumors contain neoplastic, multinucleated Reed-Sternberg cells.
d. the release of cytokines such as TNF-alpha contributes to the fever and chronic
inflammation.
ANS: A DIF: Difficult REF: 17.2
OBJ: 17.2c Explain the defects leading to B-cell neoplasms. MSC: Analyzing
10. All of the following are true about B-cell neoplasms EXCEPT
a. cancers arise in B cells when genes that control cell division are dysregulated and fail to
replicate.
b. follicular lymphoma occurs when the bcl-2 gene is activated and prevents apoptosis.
c. chronic lymphocytic leukemia occurs when there is a deletion in chromosome 13.
d. Burkitt’s lymphoma develops when the c-myo gene moves next to expressed antibody
genes.
