TEST BANKk
Cellular and Molecular Immunology
k k k
Abul Abbas, Andrew Lichtman, and Shiv Pillai
k k k k k k
10th Edition
k
PlusBay.Plus
,Table of Contents
k k
Chapterk01kPropertieskandkOverviewkofkImmunekResponses 1
Chapterk02kCellskandkTissueskofkthekImmunekSystem 3
Chapterk03kLeukocytekCirculationkandkMigrationkIntokTissues 6
Chapterk04kInnatekImmunity 10
Chapterk05kAntibodieskandkAntigens 17
Chapterk06kAntigenkPresentationktokTkLymphocyteskandkthekFunctionskofkMajor
HistocompatibilitykComplexkMolecules 20
Chapterk07kImmunekReceptorskandkSignalkTransduction 27
Chapterk08kLymphocytekDevelopmentkandkAntigenkReceptorkGenekRearrangement 30
Chapterk09kActivationkofkTkLymphocytes 34
Chapterk10kDifferentiationkandkFunctionskofkCD4+kEffectorkTkCells 38
Chapterk11kDifferentiationkandkFunctionskofkCD8+kEffectorkTkCells 42
Chapterk12kBkCellkActivationkandkAntibodykProduction 46
Chapterk13kEffectorkMechanismskofkHumoralkImmunity 52
Chapterk14kSpecializedkImmunitykatkEpithelialkBarrierskandkinkImmunekPrivilegedkTissues 56
Chapterk15kImmunologickTolerancekandkAutoimmunity 62
Chapterk16kImmunityktokMicrobes 67
Chapterk17kTransplantationkImmunology 72
Chapterk18kTumorkImmunology 77
Chapterk19kHypersensitivitykDisorders 81
Chapterk20kAllergy 86
Chapterk21kPrimarykandkAcquiredkImmunodeficiencies 89
PlusBay.Plus
,Chapter 01: Properties and Overview of Immune Responses
k k k k k k k
Abbas, Lichtman, and Pillai: Cellular and Molecular Immunology, 10th Edition
k k k k k k k k k
MULTIPLEkCHOICE
1. Thekprincipalkfunctionkofkthekimmuneksystemkis:
a. Defensekagainstkcancer
b. Repairkofkinjuredktissues
c. Defensekagainstkmicrobialkinfections
d. Preventionkofkinflammatorykdiseases
e. Protectionkagainstkenvironmentalktoxins
ANS:k k C
Thekimmuneksystemkhaskevolvedkinktheksettingkofkselectivekpressureskimposedkbykmicrobialkinfe
ctions.kAlthoughkimmunekresponsesktokcancerkmaykoccur,kthekconceptkthatk“immunosurveillanc
e”kagainstkcancerkiskakprincipalkfunctionkofkthekimmuneksystemkiskcontroversial.kRepairkofkinjure
dktissueskmaykbekaksecondarykconsequencekofkthekimmunekresponseskandkinflammation.kAlthoug
hkthekimmuneksystemkhaskregulatorykfeatureskthatkarekneededktokpreventkexcessivekinflammation
,kpreventionkofkinflammatorykdiseaseskisknotkakprimarykfunction.kThekimmuneksystemkcankprotect
kagainstkmicrobialktoxins,kbutkitkgenerallykdoesknotkofferkprotectionkagainstktoxinskofknonbiologic
korigin.
2. Whichkofkthekfollowingkinfectiouskdiseaseskwaskpreventedkbykthekfirstksuccessfulk
vaccination?
a. Polio
b. Tuberculosis
c. Smallpox
d. Tetanus
e. Rubella
ANS:k k C
Ink1798,kEdwardkJennerkreportedkthekfirstkintentionalksuccessfulkvaccination,kwhichkwaskagai
nstksmallpoxkinkakboy,kusingkmaterialkfromkthekcowpoxkpustuleskofkakmilkmaid.kInk1980,ksmall
poxkwaskreportedktokbekeradicatedkworldwidekbykakvaccinationkprogram.kEffectivekvaccineska
gainstktetanusktoxin,krubellakvirus,kandkpolioviruskwerekdevelopedkinkthek20thkcenturykandkarek
widelykused.kTherekisknokeffectivekvaccinekagainstkMycobacteriumktuberculosis.
3. Whichkofkthekfollowingkiskakuniquekpropertykofkthekadaptivekimmuneksystem?
a. Highlykdiversekrepertoirekofkspecificitieskforkantigens
b. Self-nonselfk discrimination
c. Recognitionkofkmicrobialkstructureskbykbothkcell-associatedkandksolublekreceptors
d. Protectionkagainstkviralkinfections
e. Responseskthatkhavektheksamekkineticskandkmagnitudekonkrepeatedkexposurektoktheks
amekmicrobe
ANS:k k A
PlusBay.Plus
, HighlykdiversekrepertoireskofkspecificitieskforkantigenskarekfoundkonlykinkTkandkBklymphocyte
s,kwhichkarekthekcentralkcellularkcomponentskofkthekadaptivekimmuneksystem.kBothkthekinnatek
andkthekadaptivekimmuneksystemskusekcell-
associatedkandksolublekreceptorsktokrecognizekmicrobes,kdisplayksomekdegreekofkself-
nonselfkdiscrimination,kandkprotectkagainstkviruses.kOnkrepeatedkexposurektoktheksamekmicrob
e,kthekadaptivekimmunekresponsekbecomeskmorekrapidkandkofkgreaterkmagnitude;kthiskiskthekm
anifestationkofkmemory.
4. AntibodieskandkTklymphocyteskarekthekrespectivekmediatorskofkwhichktwoktypeskofki
mmunity?
a. Innatekandkadaptive
b. Passivekandkactive
c. Specifickandknonspecific
d. Humoralkandkcell-mediated
e. Adultkandkneonatal
ANS:k k D
BothkBkandkTklymphocyteskarekprincipalkcomponentskofkadaptivekimmunity.kBklymphocyteskpr
oducekantibodies,kwhichkarekthekrecognitionkandkeffectorkmoleculeskofkhumoralkimmunekrespo
nsesktokextracellularkpathogens.kTkcellskrecognizekandkpromotekeradicationkofkintracellularkpat
hogenskinkcell-
mediatedkimmunity.kPassivekandkactivekimmunitykbothkcankbekmediatedkbykeitherkBkorkTklymp
hocytes.kSpecifickimmunitykiskanotherktermkforkadaptivekimmunity.kBothkBkandkTklymphocytes
kparticipatekinkadultkadaptivekimmunitykbutkarekstillkdevelopingkinkthekneonatalkperiod.
5. ThektwokmajorkfunctionalkclasseskofkeffectorkTklymphocyteskare:
a. HelperkTklymphocyteskandkcytotoxickTklymphocytes
b. NaturalkkillerkcellskandkcytoWtoWxW
ic.TTlBSM
ymph.oW
cyStes
c. MemorykTkcellskandkeffectorkTkcells
d. Helperkcellskandkantigen-presentingkcells
e. CytotoxickTklymphocyteskandktargetkcells
ANS:k k A
Tkcellskcankbekclassifiedkintokeffectorksubsetskthatkperformkdifferentkeffectorkfunctions.kMostke
ffectorkTkcellskarekeitherkhelperkTklymphocytes,kwhichkenhancekthekresponseskofkotherkimmun
ekcells,kincludingkphagocyteskandkBkcells,ktokinfections,korkcytotoxickTklymphocytes,kwhichkdi
rectlykkillkinfectedkcells.kNaturalkkillerkcellskareknotkTklymphocytes.
Antigen-presentingkcellskusuallykareknotkTkcells.kMemorykTkcellskareknotkeffectorkTkcells.
6. Whichkofkthekfollowingkcellktypeskiskrequiredkforkallkadaptivekhumoralkimmunekresponses?
a. Naturalkkillerkcells
b. Dendritickcells
c. CytolytickTklymphocytes
d. Bklymphocytes
e. HelperkTklymphocytes
ANS:k k D
Humoralkimmunekresponseskarekantibody-
mediatedkimmunekresponses,kandkallkantibodieskarekmadekbykBklymphocyteskandknokotherkcell
ktype.
PlusBay.Plus
Cellular and Molecular Immunology
k k k
Abul Abbas, Andrew Lichtman, and Shiv Pillai
k k k k k k
10th Edition
k
PlusBay.Plus
,Table of Contents
k k
Chapterk01kPropertieskandkOverviewkofkImmunekResponses 1
Chapterk02kCellskandkTissueskofkthekImmunekSystem 3
Chapterk03kLeukocytekCirculationkandkMigrationkIntokTissues 6
Chapterk04kInnatekImmunity 10
Chapterk05kAntibodieskandkAntigens 17
Chapterk06kAntigenkPresentationktokTkLymphocyteskandkthekFunctionskofkMajor
HistocompatibilitykComplexkMolecules 20
Chapterk07kImmunekReceptorskandkSignalkTransduction 27
Chapterk08kLymphocytekDevelopmentkandkAntigenkReceptorkGenekRearrangement 30
Chapterk09kActivationkofkTkLymphocytes 34
Chapterk10kDifferentiationkandkFunctionskofkCD4+kEffectorkTkCells 38
Chapterk11kDifferentiationkandkFunctionskofkCD8+kEffectorkTkCells 42
Chapterk12kBkCellkActivationkandkAntibodykProduction 46
Chapterk13kEffectorkMechanismskofkHumoralkImmunity 52
Chapterk14kSpecializedkImmunitykatkEpithelialkBarrierskandkinkImmunekPrivilegedkTissues 56
Chapterk15kImmunologickTolerancekandkAutoimmunity 62
Chapterk16kImmunityktokMicrobes 67
Chapterk17kTransplantationkImmunology 72
Chapterk18kTumorkImmunology 77
Chapterk19kHypersensitivitykDisorders 81
Chapterk20kAllergy 86
Chapterk21kPrimarykandkAcquiredkImmunodeficiencies 89
PlusBay.Plus
,Chapter 01: Properties and Overview of Immune Responses
k k k k k k k
Abbas, Lichtman, and Pillai: Cellular and Molecular Immunology, 10th Edition
k k k k k k k k k
MULTIPLEkCHOICE
1. Thekprincipalkfunctionkofkthekimmuneksystemkis:
a. Defensekagainstkcancer
b. Repairkofkinjuredktissues
c. Defensekagainstkmicrobialkinfections
d. Preventionkofkinflammatorykdiseases
e. Protectionkagainstkenvironmentalktoxins
ANS:k k C
Thekimmuneksystemkhaskevolvedkinktheksettingkofkselectivekpressureskimposedkbykmicrobialkinfe
ctions.kAlthoughkimmunekresponsesktokcancerkmaykoccur,kthekconceptkthatk“immunosurveillanc
e”kagainstkcancerkiskakprincipalkfunctionkofkthekimmuneksystemkiskcontroversial.kRepairkofkinjure
dktissueskmaykbekaksecondarykconsequencekofkthekimmunekresponseskandkinflammation.kAlthoug
hkthekimmuneksystemkhaskregulatorykfeatureskthatkarekneededktokpreventkexcessivekinflammation
,kpreventionkofkinflammatorykdiseaseskisknotkakprimarykfunction.kThekimmuneksystemkcankprotect
kagainstkmicrobialktoxins,kbutkitkgenerallykdoesknotkofferkprotectionkagainstktoxinskofknonbiologic
korigin.
2. Whichkofkthekfollowingkinfectiouskdiseaseskwaskpreventedkbykthekfirstksuccessfulk
vaccination?
a. Polio
b. Tuberculosis
c. Smallpox
d. Tetanus
e. Rubella
ANS:k k C
Ink1798,kEdwardkJennerkreportedkthekfirstkintentionalksuccessfulkvaccination,kwhichkwaskagai
nstksmallpoxkinkakboy,kusingkmaterialkfromkthekcowpoxkpustuleskofkakmilkmaid.kInk1980,ksmall
poxkwaskreportedktokbekeradicatedkworldwidekbykakvaccinationkprogram.kEffectivekvaccineska
gainstktetanusktoxin,krubellakvirus,kandkpolioviruskwerekdevelopedkinkthek20thkcenturykandkarek
widelykused.kTherekisknokeffectivekvaccinekagainstkMycobacteriumktuberculosis.
3. Whichkofkthekfollowingkiskakuniquekpropertykofkthekadaptivekimmuneksystem?
a. Highlykdiversekrepertoirekofkspecificitieskforkantigens
b. Self-nonselfk discrimination
c. Recognitionkofkmicrobialkstructureskbykbothkcell-associatedkandksolublekreceptors
d. Protectionkagainstkviralkinfections
e. Responseskthatkhavektheksamekkineticskandkmagnitudekonkrepeatedkexposurektoktheks
amekmicrobe
ANS:k k A
PlusBay.Plus
, HighlykdiversekrepertoireskofkspecificitieskforkantigenskarekfoundkonlykinkTkandkBklymphocyte
s,kwhichkarekthekcentralkcellularkcomponentskofkthekadaptivekimmuneksystem.kBothkthekinnatek
andkthekadaptivekimmuneksystemskusekcell-
associatedkandksolublekreceptorsktokrecognizekmicrobes,kdisplayksomekdegreekofkself-
nonselfkdiscrimination,kandkprotectkagainstkviruses.kOnkrepeatedkexposurektoktheksamekmicrob
e,kthekadaptivekimmunekresponsekbecomeskmorekrapidkandkofkgreaterkmagnitude;kthiskiskthekm
anifestationkofkmemory.
4. AntibodieskandkTklymphocyteskarekthekrespectivekmediatorskofkwhichktwoktypeskofki
mmunity?
a. Innatekandkadaptive
b. Passivekandkactive
c. Specifickandknonspecific
d. Humoralkandkcell-mediated
e. Adultkandkneonatal
ANS:k k D
BothkBkandkTklymphocyteskarekprincipalkcomponentskofkadaptivekimmunity.kBklymphocyteskpr
oducekantibodies,kwhichkarekthekrecognitionkandkeffectorkmoleculeskofkhumoralkimmunekrespo
nsesktokextracellularkpathogens.kTkcellskrecognizekandkpromotekeradicationkofkintracellularkpat
hogenskinkcell-
mediatedkimmunity.kPassivekandkactivekimmunitykbothkcankbekmediatedkbykeitherkBkorkTklymp
hocytes.kSpecifickimmunitykiskanotherktermkforkadaptivekimmunity.kBothkBkandkTklymphocytes
kparticipatekinkadultkadaptivekimmunitykbutkarekstillkdevelopingkinkthekneonatalkperiod.
5. ThektwokmajorkfunctionalkclasseskofkeffectorkTklymphocyteskare:
a. HelperkTklymphocyteskandkcytotoxickTklymphocytes
b. NaturalkkillerkcellskandkcytoWtoWxW
ic.TTlBSM
ymph.oW
cyStes
c. MemorykTkcellskandkeffectorkTkcells
d. Helperkcellskandkantigen-presentingkcells
e. CytotoxickTklymphocyteskandktargetkcells
ANS:k k A
Tkcellskcankbekclassifiedkintokeffectorksubsetskthatkperformkdifferentkeffectorkfunctions.kMostke
ffectorkTkcellskarekeitherkhelperkTklymphocytes,kwhichkenhancekthekresponseskofkotherkimmun
ekcells,kincludingkphagocyteskandkBkcells,ktokinfections,korkcytotoxickTklymphocytes,kwhichkdi
rectlykkillkinfectedkcells.kNaturalkkillerkcellskareknotkTklymphocytes.
Antigen-presentingkcellskusuallykareknotkTkcells.kMemorykTkcellskareknotkeffectorkTkcells.
6. Whichkofkthekfollowingkcellktypeskiskrequiredkforkallkadaptivekhumoralkimmunekresponses?
a. Naturalkkillerkcells
b. Dendritickcells
c. CytolytickTklymphocytes
d. Bklymphocytes
e. HelperkTklymphocytes
ANS:k k D
Humoralkimmunekresponseskarekantibody-
mediatedkimmunekresponses,kandkallkantibodieskarekmadekbykBklymphocyteskandknokotherkcell
ktype.
PlusBay.Plus
