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Pharmacology HESI Practice Exam 2025/2026 | Updated NCLEX-Style Questions & Verified Answers | Medication Safety, Side Effects, Dosage & Nursing Interventions

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Prepare confidently for your Pharmacology HESI Exam with this comprehensive 2025/2026 practice exam guide, complete with realistic NCLEX-style questions and 100% verified answers. This resource is expertly designed for nursing students preparing for the HESI-RN, HESI-PN, or NCLEX pharmacology section.

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Pharm HESI Practice Exam Latest update
(QUESTIONS AND ANSWERS) 2025/2026
1.The nurse is caring for a client who has taken atenolol for 2 years. The healthcare provider recently
changed the medication to enalapril to manage the client's blood pressure. Which instruction should the
nurse provide the client regarding the new medication?



A. Take the medication at bedtime.

B. Report presence of increased bruising.

C. Check pulse before taking medication.

D. Rise slowly when getting out of bed or chair. - answerD. Rise slowly when getting out of bed or chair.



2.A female client calls the clinic and talks with the nurse to inquire about a possible reaction after taking
amoxicillin for 5 days. She reports having vaginal discomfort, itching, and a white discharge. The nurse
should discuss which action with the client?



A. Discontinue the antibiotic because original symptoms have subsided.

B. Continue taking medication until finished until the symptoms subside.

C. Consult with healthcare provider about another treatment for this effect.

D. Use an over-the-counter (OTC) vaginal wash to flush out the secretions. - answerC. Consult with
healthcare provider about another treatment for this effect.



The nurse is making early morning rounds on a group of clients when a client begins exhibiting
symptoms of an acute asthma attack. The nurse administers a PRN prescription for a Beta 2 receptor
agonist agent. Which client response should the nurse expect?



A. Tachycardia.

B. Increased blood pressure.

C. Rapid resolution of wheezing.

D. Improved pulse oximetry values.

E. Reduce fever airway inflammation. - answerC, D

,A client prescribed atenolol has a blood pressure of 120/68 mmHg, displaying a sinus bradycardia with a
rate of 58 beats/minute, and a P-R interval of 0.24. Which action should the nurse take?



A. Lower the head of the bed and assess the client for orthostatic vital sign changes.

B. Give the medication as prescribed and continue to monitor the client.

C. Prepare to administer atropine sulfate IV push.

D. Hold the prescribed dose and contact the healthcare provider. - answerB. Give the medication as
prescribed and continue to monitor the client.



The nurse is preparing the 0900 dose of losartan (Cozaar), an angiotensin II receptor blocker (ARB), for a
client with hypertension and heart failure. The nurse reviews the client's laboratory results and notes
that the client's serum potassium level is 5.9 mEq/L. Which action should the nurse take first?



A. Withhold the scheduled dose.

B. Check the client's apical pulse.

C. Notify the healthcare provider.

D. Repeat the serum potassium level. - answerA. Withhold the scheduled dose.



Upon admission to the emergency center, an adult client with acute status asthmaticus is prescribed this
series of medications. In which order should the nurse administer the prescribed medications? (Arrange
from first to last.) - answer1. Albuterol (Proventil) puffs.

2. Salmeterol (Serevent Diskus).

3. Prednisone (Deltasone) orally.

4. Gentamicin (Garamycin) IM.



An adult client is given a prescription for a scopolamine patch (Transderm Scop) to prevent motion
sickness while on a cruise. Which information should the nurse provide to the client?



A. Apply the patch at least 4 hours prior to departure.

B. Change the patch every other day while on the cruise.

C. Place the patch on a hairless area at the base of the skull.

, D. Drink no more than 2 alcoholic drinks during the cruise. - answerA. Apply the patch at least 4 hours
prior to departure.



A client with giardiasis is taking metronidazole (Flagyl) 2 grams PO. Which information should the nurse
include in the client's instruction?



A. Notify the clinic of any changes in the color of urine.

B. Avoid overexposure to the sun.

C. Stop the medication after the diarrhea resolves.

D. Take the medication with food. - answerD. Take the medication with food.



A female client with rheumatoid arthritis takes ibuprofen (Motrin) 600 mg PO 4 times a day. To prevent
gastrointestinal bleeding, misoprostol (Cytotec) 100 mcg PO is prescribed. Which information is most
important for the nurse to include in client teaching?



A. Use contraception during intercourse.

B. Ensure the Cytotec is taken on an empty stomach.

C. Encourage oral fluid intake to prevent constipation.

D. Take Cytotec 30 minutes prior to Motrin. - answerA. Use contraception during intercourse.



A client with osteoarthritis receives a new prescription for celecoxib (Celebrex) orally for symptom
management. The nurse notes the client is allergic to sulfa. Which action is most important for the nurse
to implement prior to administering the first dose?



A. Review the client's hemoglobin results.

B. Notify the healthcare provider.

C. Inquire about the reaction to sulfa.

D. Record the client's vital signs. - answerB. Notify the healthcare provider.



A client is admitted to the hospital for a new onset of supraventricular tachycardia (SVT) and is
prescribed digoxin. For which laboratory finding should the nurse notify the healthcare provider
immediately?
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