MOA B2 agonsists activate B2 in lungs, relieve bronchospasm, supress histamine in lungs,
increase cilliary
SABAS albuterol, levabutrerol
LABA salmeterol
theophylline admin PO
this med has high risk of toxicity theophylline
combined drugs for long term asthma maintenence glucocorticoid and LABA
fluticasone, budesonide examples of glucocorticoids
function of anticholinergic drugs improve lung function by blocking muscarinic in the
bronchi; reduce bronchospasm
ending anticholinergic drugs "ium" ipratropium, tiotropium
side effects of anticholinergic drugs dry mouth, constipation, urinary retention
initial therapies for acute severe exacerbations giving oxygen, systemic glucocorticoid,
NEBULIZED SABA, nebulized anticholinergic
trimacinolone glucocotcoid
,should you take the glucococoid or SABA first SABA, it opens the airways and allows more
glucocorticoid in
line of demarcation larynx/vocal cords
pneumonia and TB lower respiratory tract infection
most common cause of short term disability in the US respiratory tract infection
upper respiratory tract infection common cold, pharyngitis, laryngitis
6th leading cause of death in US pneumonia
causative organisms of pneumonia strep, influenza, Respiratory syncytial virus,
pseudomonis aeruginonsa
Strep Pneumonia process aspiration of oropharyngeal, inflammatory response w release of
histamine and TNF
VAP ventilator associated pneumonia, mortality rate 15-70%, semi fowlers helps by reducing
accumulation of secretions in back of throat
HIV affected pneumonia pneumocystis jirovecki
causative organism of TB mycobacterium tuberculosis
primary infection of TB airborne transmission
, primary medications for TB isoniazid, rifampin, pyrazinamide, ethambutol; monitor liver
function
why is TB treated with two or more drugs reduces resistance, reduces incidence of relapse,
does not appear to increase incidence of suprainfection
use of zinc in common cold blocks viral binding to nasal epithelium
OTC cold remedies nasal decongestant, antitussive, analgesic, antihistamine, caffeine
caffeine in colds dilates bronchioles
why should one avoid OTC cold meds in pediatric patients less developed BBB AVOID in 2
years and younger
allergic rhinitis inflammatory disorder of upper airway, lower airway, and eyes
inflammatory mediators released in allergic rhinitis histamines, leukotrienes, prostaglandins
classes of drugs used for rhinitis antihistamines, intranasal glucocorticoids,
sympathomimetics
use for antihistamines allergic rhinitis, not effective on common cold, most effective in
preventative
pulmacort and flovent are glucocorcoids