NR 565 - advanced pharmacology midterm –
Chamberlain/ NR 565 - Advanced
Pharmacology Midterm Practice Exam|
Questions With Verified Answers -
Chamberlain
During what trimester is a pregnant woman most at risk for adverse
drug reactions with potential long term consequences? - ✔✔ANSWER
✔✔-1st trimester (fetus most at risk d/t rapid growth)
,What is BEERS criteria? - ✔✔ANSWER✔✔-Recommendations of
medications inappropriate for elderly (65 and older), prescriber
ultimately decides
What is the CYP450 (cytochrome P450) - ✔✔ANSWER✔✔-liver
enzyme system where medications are metabolized, can either be
inducers or inhibitors and create drug-drug interactions
CYP450 inducers - ✔✔ANSWER✔✔-Speed up metabolism of drugs
(drug is cleared faster), drug has lesser effect (decrease blood levels of
drug), elevate CYP450 enzymes
CYP450 inducers pneumonic - ✔✔ANSWER✔✔-"Bullshit Crap GPS
INDUCES rage"
CYP450 inducer drug names - ✔✔ANSWER✔✔-Barbituates, St John
wort, Carbamazepine, rifampin, alcohol, phenytoin, griseofulvin,
phenobarbital, sulfonylureas
CYP450 inhibitors - ✔✔ANSWER✔✔-inhibit metabolism, increase
blood levels of medications
,How can we promote medication adherence with elderly patients? - ✔
✔ANSWER✔✔-simplifying drug regimens
providing clear and concise verbal and written instructions
using an appropriate dosage form
clearly labeling and dispensing easy-to-open containers
developing daily reminders
monitoring frequently
affordability of drugs
support systems
Why do nitrates need to be taken no later than 4 PM? - ✔✔ANSWER
✔✔-Need nitrate free interval so tolerance doesn't develop
Nine factors that impact outcome of medication? - ✔✔ANSWER✔✔-
Gender and race
Genetics and pharmacogenomics
Variability in absorption
placebo effect
Tolerance
patho
, age
bodyweight
CYP450 pneumonic - ✔✔ANSWER✔✔-"VISA credit card debt
INHIBITS spending on designers like CK to look GQ"
CYP450 inhibitors drug names - ✔✔ANSWER✔✔-Valproate,
isoniazid, sulfonamides, amiodarone, chloramphenicol, ketoconazole,
grapefruit juice, quinidine
Physiological changes during pregnancy that impact pharmacodynamics
and pharmacokinetic properties of drugs? - ✔✔ANSWER✔✔-
increase glomerular filtration rate leads to increase durg excretion
increase hepatic metabolism
decrease tone and motility of bowel
increase drug absorption
Examples of medications that can be teratogenic - ✔✔ANSWER✔✔-
Antiepileptic drugs, antimicrobials such as tetracyclines and
fluoroquinolones, vitamin A in large doses, some anticoagulants, and
hormonal medications such as diethylstilbestrol (DES).
Chamberlain/ NR 565 - Advanced
Pharmacology Midterm Practice Exam|
Questions With Verified Answers -
Chamberlain
During what trimester is a pregnant woman most at risk for adverse
drug reactions with potential long term consequences? - ✔✔ANSWER
✔✔-1st trimester (fetus most at risk d/t rapid growth)
,What is BEERS criteria? - ✔✔ANSWER✔✔-Recommendations of
medications inappropriate for elderly (65 and older), prescriber
ultimately decides
What is the CYP450 (cytochrome P450) - ✔✔ANSWER✔✔-liver
enzyme system where medications are metabolized, can either be
inducers or inhibitors and create drug-drug interactions
CYP450 inducers - ✔✔ANSWER✔✔-Speed up metabolism of drugs
(drug is cleared faster), drug has lesser effect (decrease blood levels of
drug), elevate CYP450 enzymes
CYP450 inducers pneumonic - ✔✔ANSWER✔✔-"Bullshit Crap GPS
INDUCES rage"
CYP450 inducer drug names - ✔✔ANSWER✔✔-Barbituates, St John
wort, Carbamazepine, rifampin, alcohol, phenytoin, griseofulvin,
phenobarbital, sulfonylureas
CYP450 inhibitors - ✔✔ANSWER✔✔-inhibit metabolism, increase
blood levels of medications
,How can we promote medication adherence with elderly patients? - ✔
✔ANSWER✔✔-simplifying drug regimens
providing clear and concise verbal and written instructions
using an appropriate dosage form
clearly labeling and dispensing easy-to-open containers
developing daily reminders
monitoring frequently
affordability of drugs
support systems
Why do nitrates need to be taken no later than 4 PM? - ✔✔ANSWER
✔✔-Need nitrate free interval so tolerance doesn't develop
Nine factors that impact outcome of medication? - ✔✔ANSWER✔✔-
Gender and race
Genetics and pharmacogenomics
Variability in absorption
placebo effect
Tolerance
patho
, age
bodyweight
CYP450 pneumonic - ✔✔ANSWER✔✔-"VISA credit card debt
INHIBITS spending on designers like CK to look GQ"
CYP450 inhibitors drug names - ✔✔ANSWER✔✔-Valproate,
isoniazid, sulfonamides, amiodarone, chloramphenicol, ketoconazole,
grapefruit juice, quinidine
Physiological changes during pregnancy that impact pharmacodynamics
and pharmacokinetic properties of drugs? - ✔✔ANSWER✔✔-
increase glomerular filtration rate leads to increase durg excretion
increase hepatic metabolism
decrease tone and motility of bowel
increase drug absorption
Examples of medications that can be teratogenic - ✔✔ANSWER✔✔-
Antiepileptic drugs, antimicrobials such as tetracyclines and
fluoroquinolones, vitamin A in large doses, some anticoagulants, and
hormonal medications such as diethylstilbestrol (DES).
