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Cellular and Molecular Immunology
Abul Abbas, Andrew Lichtman, and Shiv Pillai
10th Edition
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,TablewkofwkContents
Chapterwk01wkPropertieswkandwkOverviewwkofwkImmunewkResponses 1
Chapterwk02wkCellswkandwkTissueswkofwkthewkImmunewkSystem 3
Chapterwk03wkLeukocytewkCirculationwkandwkMigrationwkIntowkTissues 6
Chapterwk04wkInnatewkImmunity 10
Chapterwk05wkAntibodieswkandwkAntigens 17
Chapterwk06wkAntigenwkPresentationwktowkTwkLymphocyteswkandwkthewkFunctionswkofwkMajor
HistocompatibilitywkComplexwkMolecules 20
Chapterwk07wkImmunewkReceptorswkandwkSignalwkTransduction 27
Chapterwk08wkLymphocytewkDevelopmentwkandwkAntigenwkReceptorwkGenewkRearrangement 30
Chapterwk09wkActivationwkofwkTwkLymphocytes 34
Chapterwk10wkDifferentiationwkandwkFunctionswkofwkCD4+wkEffectorwkTwkCells 38
Chapterwk11wkDifferentiationwkandwkFunctionswkofwkCD8+wkEffectorwkTwkCells 42
Chapterwk12wkBwkCellwkActivationwkandwkAntibodywkProduction 46
Chapterwk13wkEffectorwkMechanismswkofwkHumoralwkImmunity 52
Chapterwk14wkSpecializedwkImmunitywkatwkEpithelialwkBarrierswkandwkinwkImmunewkPrivilegedwkTissues 56
Chapterwk15wkImmunologicwkTolerancewkandwkAutoimmunity 62
Chapterwk16wkImmunitywktowkMicrobes 67
Chapterwk17wkTransplantationwkImmunology 72
Chapterwk18wkTumorwkImmunology 77
Chapterwk19wkHypersensitivitywkDisorders 81
Chapterwk20wkAllergy 86
Chapterwk21wkPrimarywkandwkAcquiredwkImmunodeficiencies 89
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,Chapterwk01:wkPropertieswkandwkOverviewwkofwkImmunewkResponses
Abbas,wkLichtman,wkandwkPillai:wkCellularwkandwkMolecularwkImmunology,wk10thwkEdition
MULTIPLEwkCHOICE
1. Thewkprincipalwkfunctionwkofwkthewkimmunewksystemwkis:
a. Defensewkagainstwkcancer
b. Repairwkofwkinjuredwktissues
c. Defensewkagainstwkmicrobialwkinfections
d. Preventionwkofwkinflammatorywkdiseases
e. Protectionwkagainstwkenvironmentalwktoxins
ANS:w k w k C
Thewkimmunewksystemwkhaswkevolvedwkinwkthewksettingwkofwkselectivewkpressureswkimposedw
kbywkmicrobialwkinfections.wkAlthoughwkimmunewkresponseswktowkcancerwkmaywkoccur,wkthew
kconceptwkthatwk“immunosurveillance”wkagainstwkcancerwkiswkawkprincipalwkfunctionwkofwkthe
wkimmunewksystemwkiswkcontroversial.wkRepairwkofwkinjuredwktissueswkmaywkbewkawksecondar
ywkconsequencewkofwkthewkimmunewkresponseswkandwkinflammation.wkAlthoughwkthewkimmu
newksystemwkhaswkregulatorywkfeatureswkthatwkarewkneededwktowkpreventwkexcessivewkinflamm
ation,wkpreventionwkofwkinflammatorywkdiseaseswkiswknotwkawkprimarywkfunction.wkThewkimm
unewksystemwkcanwkprotectwkagainstwkmicrobialwktoxins,wkbutwkitwkgenerallywkdoeswknotwkoffe
rwkprotectionwkagainstwktoxinswkofwknonbiologicwkorigin.
2. Whichwkofwkthewkfollowingwkinfectiouswkdiseaseswkwaswkpreventedwkbywkthewkfi
rstwksuccessfulwkvaccination?
a. Polio
b. Tuberculosis
c. Smallpox
d. Tetanus
e. Rubella
ANS:w k w k C
Inwk1798,wkEdwardwkJennerwkreportedwkthewkfirstwkintentionalwksuccessfulwkvaccination,wk
whichwkwaswkagainstwksmallpoxwkinwkawkboy,wkusingwkmaterialwkfromwkthewkcowpoxwkpust
uleswkofwkawkmilkmaid.wkInwk1980,wksmallpoxwkwaswkreportedwktowkbewkeradicatedwkworld
widewkbywkawkvaccinationwkprogram.wkEffectivewkvaccineswkagainstwktetanuswktoxin,wkrube
llawkvirus,wkandwkpolioviruswkwerewkdevelopedwkinwkthewk20thwkcenturywkandwkarewkwidely
wkused.wkTherewkiswknowkeffectivewkvaccinewkagainstwkMycobacteriumwktuberculosis.
3. Whichwkofwkthewkfollowingwkiswkawkuniquewkpropertywkofwkthewkadaptivewkimmunewksystem?
a. Highlywkdiversewkrepertoirewkofwkspecificitieswkforwkantigens
b. Self-nonselfwk discrimination
c. Recognitionwkofwkmicrobialwkstructureswkbywkbothwkcell-
associatedwkandwksolublewkreceptors
d. Protectionwkagainstwkviralwkinfections
e. Responseswkthatwkhavewkthewksamewkkineticswkandwkmagnitudewkonwkrepeatedwke
xposurewktowkthewksamewkmicrobe
ANS:w k w k A
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, HighlywkdiversewkrepertoireswkofwkspecificitieswkforwkantigenswkarewkfoundwkonlywkinwkTwk
andwkBwklymphocytes,wkwhichwkarewkthewkcentralwkcellularwkcomponentswkofwkthewkadapti
vewkimmunewksystem.wkBothwkthewkinnatewkandwkthewkadaptivewkimmunewksystemswkusewkc
ell-
associatedwkandwksolublewkreceptorswktowkrecognizewkmicrobes,wkdisplaywksomewkdegreewk
ofwkself-
nonselfwkdiscrimination,wkandwkprotectwkagainstwkviruses.wkOnwkrepeatedwkexposurewktowkt
hewksamewkmicrobe,wkthewkadaptivewkimmunewkresponsewkbecomeswkmorewkrapidwkandwkof
wkgreaterwkmagnitude;wkthiswkiswkthewkmanifestationwkofwkmemory.
4. AntibodieswkandwkTwklymphocyteswkarewkthewkrespectivewkmediatorswkofwkwhich
wktwowktypeswkofwkimmunity?
a. Innatewkandwkadaptive
b. Passivewkandwkactive
c. Specificwkandwknonspecific
d. Humoralwkandwkcell-mediated
e. Adultwkandwkneonatal
ANS:w k w k D
BothwkBwkandwkTwklymphocyteswkarewkprincipalwkcomponentswkofwkadaptivewkimmunity.wk
Bwklymphocyteswkproducewkantibodies,wkwhichwkarewkthewkrecognitionwkandwkeffectorwkmol
eculeswkofwkhumoralwkimmunewkresponseswktowkextracellularwkpathogens.wkTwkcellswkrecog
nizewkandwkpromotewkeradicationwkofwkintracellularwkpathogenswkinwkcell-
mediatedwkimmunity.wkPassivewkandwkactivewkimmunitywkbothwkcanwkbewkmediatedwkbywkeit
herwkBwkorwkTwklymphocytes.wkSpecificwkimmunitywkiswkanotherwktermwkforwkadaptivewkim
munity.wkBothwkBwkandwkTwklymphocyteswkparticipatewkinwkadultwkadaptivewkimmunitywkb
utwkarewkstillwkdevelopingwkinwkthewkneonatalwkperiod.
5. ThewktwowkmajorwkfunctionalwkclasseswkofwkeffectorwkTwklymphocyteswkare:
a. HelperwkTwklymphocyteswkandwkcytotoxicwkTwklymphocytes
b. NaturalwkkillerwkcellswkandwkcytoWtoWxW
ic.TTlBSM
ymph.oW
cyStes
c. MemorywkTwkcellswkandwkeffectorwkTwkcells
d. Helperwkcellswkandwkantigen-presentingwkcells
e. CytotoxicwkTwklymphocyteswkandwktargetwkcells
ANS:w k w k A
Twkcellswkcanwkbewkclassifiedwkintowkeffectorwksubsetswkthatwkperformwkdifferentwkeffectorw
kfunctions.wkMostwkeffectorwkTwkcellswkarewkeitherwkhelperwkTwklymphocytes,wkwhichwkenh
ancewkthewkresponseswkofwkotherwkimmunewkcells,wkincludingwkphagocyteswkandwkBwkcells,
wktowkinfections,wkorwkcytotoxicwkTwklymphocytes,wkwhichwkdirectlywkkillwkinfectedwkcells.
wkNaturalwkkillerwkcellswkarewknotwkTwklymphocytes.
Antigen-
presentingwkcellswkusuallywkarewknotwkTwkcells.wkMemorywkTwkcellswkarewknotwkeffectorwkTwkce
lls.
6. Whichwkofwkthewkfollowingwkcellwktypeswkiswkrequiredwkforwkallwkadaptivewkhumoralwkimmune
wkresponses?
a. Naturalwkkillerwkcells
b. Dendriticwkcells
c. CytolyticwkTwklymphocytes
d. Bwklymphocytes
e. HelperwkTwklymphocytes
ANS:w k w k D
PlusBay.Plus
Cellular and Molecular Immunology
Abul Abbas, Andrew Lichtman, and Shiv Pillai
10th Edition
PlusBay.Plus
,TablewkofwkContents
Chapterwk01wkPropertieswkandwkOverviewwkofwkImmunewkResponses 1
Chapterwk02wkCellswkandwkTissueswkofwkthewkImmunewkSystem 3
Chapterwk03wkLeukocytewkCirculationwkandwkMigrationwkIntowkTissues 6
Chapterwk04wkInnatewkImmunity 10
Chapterwk05wkAntibodieswkandwkAntigens 17
Chapterwk06wkAntigenwkPresentationwktowkTwkLymphocyteswkandwkthewkFunctionswkofwkMajor
HistocompatibilitywkComplexwkMolecules 20
Chapterwk07wkImmunewkReceptorswkandwkSignalwkTransduction 27
Chapterwk08wkLymphocytewkDevelopmentwkandwkAntigenwkReceptorwkGenewkRearrangement 30
Chapterwk09wkActivationwkofwkTwkLymphocytes 34
Chapterwk10wkDifferentiationwkandwkFunctionswkofwkCD4+wkEffectorwkTwkCells 38
Chapterwk11wkDifferentiationwkandwkFunctionswkofwkCD8+wkEffectorwkTwkCells 42
Chapterwk12wkBwkCellwkActivationwkandwkAntibodywkProduction 46
Chapterwk13wkEffectorwkMechanismswkofwkHumoralwkImmunity 52
Chapterwk14wkSpecializedwkImmunitywkatwkEpithelialwkBarrierswkandwkinwkImmunewkPrivilegedwkTissues 56
Chapterwk15wkImmunologicwkTolerancewkandwkAutoimmunity 62
Chapterwk16wkImmunitywktowkMicrobes 67
Chapterwk17wkTransplantationwkImmunology 72
Chapterwk18wkTumorwkImmunology 77
Chapterwk19wkHypersensitivitywkDisorders 81
Chapterwk20wkAllergy 86
Chapterwk21wkPrimarywkandwkAcquiredwkImmunodeficiencies 89
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,Chapterwk01:wkPropertieswkandwkOverviewwkofwkImmunewkResponses
Abbas,wkLichtman,wkandwkPillai:wkCellularwkandwkMolecularwkImmunology,wk10thwkEdition
MULTIPLEwkCHOICE
1. Thewkprincipalwkfunctionwkofwkthewkimmunewksystemwkis:
a. Defensewkagainstwkcancer
b. Repairwkofwkinjuredwktissues
c. Defensewkagainstwkmicrobialwkinfections
d. Preventionwkofwkinflammatorywkdiseases
e. Protectionwkagainstwkenvironmentalwktoxins
ANS:w k w k C
Thewkimmunewksystemwkhaswkevolvedwkinwkthewksettingwkofwkselectivewkpressureswkimposedw
kbywkmicrobialwkinfections.wkAlthoughwkimmunewkresponseswktowkcancerwkmaywkoccur,wkthew
kconceptwkthatwk“immunosurveillance”wkagainstwkcancerwkiswkawkprincipalwkfunctionwkofwkthe
wkimmunewksystemwkiswkcontroversial.wkRepairwkofwkinjuredwktissueswkmaywkbewkawksecondar
ywkconsequencewkofwkthewkimmunewkresponseswkandwkinflammation.wkAlthoughwkthewkimmu
newksystemwkhaswkregulatorywkfeatureswkthatwkarewkneededwktowkpreventwkexcessivewkinflamm
ation,wkpreventionwkofwkinflammatorywkdiseaseswkiswknotwkawkprimarywkfunction.wkThewkimm
unewksystemwkcanwkprotectwkagainstwkmicrobialwktoxins,wkbutwkitwkgenerallywkdoeswknotwkoffe
rwkprotectionwkagainstwktoxinswkofwknonbiologicwkorigin.
2. Whichwkofwkthewkfollowingwkinfectiouswkdiseaseswkwaswkpreventedwkbywkthewkfi
rstwksuccessfulwkvaccination?
a. Polio
b. Tuberculosis
c. Smallpox
d. Tetanus
e. Rubella
ANS:w k w k C
Inwk1798,wkEdwardwkJennerwkreportedwkthewkfirstwkintentionalwksuccessfulwkvaccination,wk
whichwkwaswkagainstwksmallpoxwkinwkawkboy,wkusingwkmaterialwkfromwkthewkcowpoxwkpust
uleswkofwkawkmilkmaid.wkInwk1980,wksmallpoxwkwaswkreportedwktowkbewkeradicatedwkworld
widewkbywkawkvaccinationwkprogram.wkEffectivewkvaccineswkagainstwktetanuswktoxin,wkrube
llawkvirus,wkandwkpolioviruswkwerewkdevelopedwkinwkthewk20thwkcenturywkandwkarewkwidely
wkused.wkTherewkiswknowkeffectivewkvaccinewkagainstwkMycobacteriumwktuberculosis.
3. Whichwkofwkthewkfollowingwkiswkawkuniquewkpropertywkofwkthewkadaptivewkimmunewksystem?
a. Highlywkdiversewkrepertoirewkofwkspecificitieswkforwkantigens
b. Self-nonselfwk discrimination
c. Recognitionwkofwkmicrobialwkstructureswkbywkbothwkcell-
associatedwkandwksolublewkreceptors
d. Protectionwkagainstwkviralwkinfections
e. Responseswkthatwkhavewkthewksamewkkineticswkandwkmagnitudewkonwkrepeatedwke
xposurewktowkthewksamewkmicrobe
ANS:w k w k A
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, HighlywkdiversewkrepertoireswkofwkspecificitieswkforwkantigenswkarewkfoundwkonlywkinwkTwk
andwkBwklymphocytes,wkwhichwkarewkthewkcentralwkcellularwkcomponentswkofwkthewkadapti
vewkimmunewksystem.wkBothwkthewkinnatewkandwkthewkadaptivewkimmunewksystemswkusewkc
ell-
associatedwkandwksolublewkreceptorswktowkrecognizewkmicrobes,wkdisplaywksomewkdegreewk
ofwkself-
nonselfwkdiscrimination,wkandwkprotectwkagainstwkviruses.wkOnwkrepeatedwkexposurewktowkt
hewksamewkmicrobe,wkthewkadaptivewkimmunewkresponsewkbecomeswkmorewkrapidwkandwkof
wkgreaterwkmagnitude;wkthiswkiswkthewkmanifestationwkofwkmemory.
4. AntibodieswkandwkTwklymphocyteswkarewkthewkrespectivewkmediatorswkofwkwhich
wktwowktypeswkofwkimmunity?
a. Innatewkandwkadaptive
b. Passivewkandwkactive
c. Specificwkandwknonspecific
d. Humoralwkandwkcell-mediated
e. Adultwkandwkneonatal
ANS:w k w k D
BothwkBwkandwkTwklymphocyteswkarewkprincipalwkcomponentswkofwkadaptivewkimmunity.wk
Bwklymphocyteswkproducewkantibodies,wkwhichwkarewkthewkrecognitionwkandwkeffectorwkmol
eculeswkofwkhumoralwkimmunewkresponseswktowkextracellularwkpathogens.wkTwkcellswkrecog
nizewkandwkpromotewkeradicationwkofwkintracellularwkpathogenswkinwkcell-
mediatedwkimmunity.wkPassivewkandwkactivewkimmunitywkbothwkcanwkbewkmediatedwkbywkeit
herwkBwkorwkTwklymphocytes.wkSpecificwkimmunitywkiswkanotherwktermwkforwkadaptivewkim
munity.wkBothwkBwkandwkTwklymphocyteswkparticipatewkinwkadultwkadaptivewkimmunitywkb
utwkarewkstillwkdevelopingwkinwkthewkneonatalwkperiod.
5. ThewktwowkmajorwkfunctionalwkclasseswkofwkeffectorwkTwklymphocyteswkare:
a. HelperwkTwklymphocyteswkandwkcytotoxicwkTwklymphocytes
b. NaturalwkkillerwkcellswkandwkcytoWtoWxW
ic.TTlBSM
ymph.oW
cyStes
c. MemorywkTwkcellswkandwkeffectorwkTwkcells
d. Helperwkcellswkandwkantigen-presentingwkcells
e. CytotoxicwkTwklymphocyteswkandwktargetwkcells
ANS:w k w k A
Twkcellswkcanwkbewkclassifiedwkintowkeffectorwksubsetswkthatwkperformwkdifferentwkeffectorw
kfunctions.wkMostwkeffectorwkTwkcellswkarewkeitherwkhelperwkTwklymphocytes,wkwhichwkenh
ancewkthewkresponseswkofwkotherwkimmunewkcells,wkincludingwkphagocyteswkandwkBwkcells,
wktowkinfections,wkorwkcytotoxicwkTwklymphocytes,wkwhichwkdirectlywkkillwkinfectedwkcells.
wkNaturalwkkillerwkcellswkarewknotwkTwklymphocytes.
Antigen-
presentingwkcellswkusuallywkarewknotwkTwkcells.wkMemorywkTwkcellswkarewknotwkeffectorwkTwkce
lls.
6. Whichwkofwkthewkfollowingwkcellwktypeswkiswkrequiredwkforwkallwkadaptivewkhumoralwkimmune
wkresponses?
a. Naturalwkkillerwkcells
b. Dendriticwkcells
c. CytolyticwkTwklymphocytes
d. Bwklymphocytes
e. HelperwkTwklymphocytes
ANS:w k w k D
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