ATI Proctored Pharmacolgy Remediation Study Notes

Tumor lysis syndrome: When cancerous tumors break down very quickly, the kidneys have to work extra hard to remove all the substances that were in those tumors. If they can’t keep up, it can cause tumor lysis syndrome (TLS). Most common in people w/ blood-related cancers, including some leukemias & lymphomas. Occurs w/in a few hours to several days after a first chemotherapy tx. S/S: High levels of potassium can lead to neurological changes & heart problems. Excess uric acid (hyperuricemia) can cause kidney stones & kidney damage, can also develop uric acid deposits in joints, causing a painful condition similar to gout. A buildup of phosphate can lead to kidney failure. Too much phosphate can also cause calcium levels to drop, possibly leading to acute kidney failure.