Chapter 30: Alterations of Leukocyte,
Lymphoid Function UPDATED ACTUAL
Exam Questions and CORRECT Answers
What change is observed in leukocytes during an allergic disorder (type I hypersensitivity) often
caused by asthma, hay fever, and drug reactions?
a. Neutrophilia
b. Basophilia
c. Eosinophilia
d. Monocytosis - CORRECT ANSWER - c. Eosinophilia
Eosinophilia is an absolute increase (more than 450/μL) in the total numbers of circulating
eosinophils. Allergic disorders (type I hypersensitivity) associated with asthma, hay fever, and
drug reactions, as well as parasitic infections (particularly with metazoal parasites), are often
cited as causes.
In infectious mononucleosis (IM), what does the Monospot test detect?
a. Immunoglobulin E (IgE)
b. Immunoglobulin M (IgM)
c. Immunoglobulin G (IgG)
d. Immunoglobulin A (IgA) - CORRECT ANSWER - b. Immunoglobulin M (IgM)
Heterophile antibodies are a heterogeneous group of IgM antibodies that are agglutinins against
nonhuman red blood cells (e.g., sheep, horse) and are detected by qualitative (monospot) or
quantitative (heterophile antibody) test methods.
Which description is consistent with acute lymphocytic leukemia (ALL)?
a. ALL is a progressive neoplasm defined by the presence of greater than 30% lymphoblasts in
the bone marrow or blood.
b. Leukocytosis and a predominance of blast cells characterize the bone marrow and peripheral
blood. As the immature blasts increase, they replace normal myelocytic cells, megakaryocytes,
and erythrocytes.
c. B cells fail to mature into plasma cells that synthesize immunoglobulins.
, d. The translocation of genetic material from genes 9 and 22 create an abnormal, fused gene
identified as BCR-ABL. - CORRECT ANSWER - a. ALL is a progressive neoplasm
defined by the presence of greater than 30% lymphoblasts in the bone marrow or blood.
ALL is a progressive neoplasm defined by the presence of greater than 30% lymphoblasts in the
bone marrow or blood.
Which description is consistent with chronic myelogenous leukemia (CML)?
a. Defects exist in the ras oncogene, TP53 tumor-suppressor gene, and INK4A, the gene
encoding a cell-cycle regulatory protein.
b. Leukocytosis and a predominance of blast cells characterize the bone marrow and peripheral
blood. As the immature blasts increase, they replace normal myelocytic cells, megakaryocytes,
and erythrocytes.
c. B cells fail to mature into plasma cells that synthesize immunoglobulins.
d. The translocation of genetic material from genes 9 and 22 creates an abnormal, fused protein
identified as BCR-ABL1. - CORRECT ANSWER - d. The translocation of genetic
material from genes 9 and 22 creates an abnormal, fused protein identified as BCR-ABL1.
The Philadelphia chromosome is present in more than 95% of those with CML, and the presence
of the BCR-ABL1 protein is responsible for the initiation of CML.
Which description is consistent with chronic lymphocytic leukemia (CLL)?
a. Defects exist in the ras oncogene, TP53 tumor-suppressor gene, and INK4A, the gene
encoding a cell-cycle regulatory protein.
b. Leukocytosis and a predominance of blast cells characterize the bone marrow and peripheral
blood. As the immature blasts increase, they replace normal myelocytic cells, megakaryocytes,
and erythrocytes.
c. B cells fail to mature into plasma cells that synthesize immunoglobulins.
d. The translocation of genetic material from genes 9 and 22 creates an abnormal, fused protein
identified as BCR-ABL. - CORRECT ANSWER - c. B cells fail to mature into plasma
cells that synthesize immunoglobulins.
CLL is derived from transformation of a partially mature B cell that has not yet encountered
antigen.
Which electrolyte imbalance accompanies multiple myeloma (MM)?
Lymphoid Function UPDATED ACTUAL
Exam Questions and CORRECT Answers
What change is observed in leukocytes during an allergic disorder (type I hypersensitivity) often
caused by asthma, hay fever, and drug reactions?
a. Neutrophilia
b. Basophilia
c. Eosinophilia
d. Monocytosis - CORRECT ANSWER - c. Eosinophilia
Eosinophilia is an absolute increase (more than 450/μL) in the total numbers of circulating
eosinophils. Allergic disorders (type I hypersensitivity) associated with asthma, hay fever, and
drug reactions, as well as parasitic infections (particularly with metazoal parasites), are often
cited as causes.
In infectious mononucleosis (IM), what does the Monospot test detect?
a. Immunoglobulin E (IgE)
b. Immunoglobulin M (IgM)
c. Immunoglobulin G (IgG)
d. Immunoglobulin A (IgA) - CORRECT ANSWER - b. Immunoglobulin M (IgM)
Heterophile antibodies are a heterogeneous group of IgM antibodies that are agglutinins against
nonhuman red blood cells (e.g., sheep, horse) and are detected by qualitative (monospot) or
quantitative (heterophile antibody) test methods.
Which description is consistent with acute lymphocytic leukemia (ALL)?
a. ALL is a progressive neoplasm defined by the presence of greater than 30% lymphoblasts in
the bone marrow or blood.
b. Leukocytosis and a predominance of blast cells characterize the bone marrow and peripheral
blood. As the immature blasts increase, they replace normal myelocytic cells, megakaryocytes,
and erythrocytes.
c. B cells fail to mature into plasma cells that synthesize immunoglobulins.
, d. The translocation of genetic material from genes 9 and 22 create an abnormal, fused gene
identified as BCR-ABL. - CORRECT ANSWER - a. ALL is a progressive neoplasm
defined by the presence of greater than 30% lymphoblasts in the bone marrow or blood.
ALL is a progressive neoplasm defined by the presence of greater than 30% lymphoblasts in the
bone marrow or blood.
Which description is consistent with chronic myelogenous leukemia (CML)?
a. Defects exist in the ras oncogene, TP53 tumor-suppressor gene, and INK4A, the gene
encoding a cell-cycle regulatory protein.
b. Leukocytosis and a predominance of blast cells characterize the bone marrow and peripheral
blood. As the immature blasts increase, they replace normal myelocytic cells, megakaryocytes,
and erythrocytes.
c. B cells fail to mature into plasma cells that synthesize immunoglobulins.
d. The translocation of genetic material from genes 9 and 22 creates an abnormal, fused protein
identified as BCR-ABL1. - CORRECT ANSWER - d. The translocation of genetic
material from genes 9 and 22 creates an abnormal, fused protein identified as BCR-ABL1.
The Philadelphia chromosome is present in more than 95% of those with CML, and the presence
of the BCR-ABL1 protein is responsible for the initiation of CML.
Which description is consistent with chronic lymphocytic leukemia (CLL)?
a. Defects exist in the ras oncogene, TP53 tumor-suppressor gene, and INK4A, the gene
encoding a cell-cycle regulatory protein.
b. Leukocytosis and a predominance of blast cells characterize the bone marrow and peripheral
blood. As the immature blasts increase, they replace normal myelocytic cells, megakaryocytes,
and erythrocytes.
c. B cells fail to mature into plasma cells that synthesize immunoglobulins.
d. The translocation of genetic material from genes 9 and 22 creates an abnormal, fused protein
identified as BCR-ABL. - CORRECT ANSWER - c. B cells fail to mature into plasma
cells that synthesize immunoglobulins.
CLL is derived from transformation of a partially mature B cell that has not yet encountered
antigen.
Which electrolyte imbalance accompanies multiple myeloma (MM)?
