NR 565 Midterm 2023 Questions and
Answers Verified by Experts
What routine monitoring is needed for Methotrexate? Correct Ans-Periodic liver & renal fxn
What blood level do we expect to see elevated in a patient with gout? Correct Ans-Uric acid
First line Tx for gout Correct Ans-Corticosteroids, NSAIDs, or Colchicine
What is the typical treatment regimen for chronic gout? Correct Ans-Allopurinol, Febuxostat,
low dose Colchicine (prophylaxis)
MOA of febuxostat Correct Ans-inhibits xanthine oxidase ->decreased production of uric acid
Is allopurinol safe to use with patient who have renal dysfunction? Correct Ans-Yes; Rx of
choice for pts with renal dysfxn or who overproduce uric acid
What is the initial dosage of colchicine for acute gout? Correct Ans-0.6mg TID on 1st day
,OR
1.2mg x 1 -> 0.6mgx1 in 1 hour; on subsequent days, 1-2/day until flare resolution
What is required to diagnose Osteoporosis? Correct Ans-DXA scan
T score of -2.5 or lower
T score of -1 to -2.5 PLUS one of the following:
10yr prob. of hip Frx of 3% or more OR
10 yr prob of osteoperosis r/t frx of 20% or more
What is the most common fracture seen in Severe Osteoporosis? Correct Ans-Hip & Vertebrae
What is the first-line treatment of osteoporosis? Correct Ans-Bisphosphonates with calcium
and vitamin D supplementation.
, Bisphophosphonates- examples Correct Ans-Alendronate, ibandronate, risedronate,
zolendronic acid
"-dronate"
"-dron-"
Pt education for bisphosphonates Correct Ans-Swallow tab whole
take with full glass of H2O
remain upright for at least 30min (60min for ibandronate)
Take medication on empty stomach
Possible AEs of bisphosphonates Correct Ans-Esophagitis, osteonecrosis of the jaw, & hip frx
MOA of bisphosphonates Correct Ans-Inhibits osteoclast bone resorption
Black box warning for Raloxifene Correct Ans-Increased risk for VTE
Increased risk for death from stroke in PM women with Hx or risk of CAD
Answers Verified by Experts
What routine monitoring is needed for Methotrexate? Correct Ans-Periodic liver & renal fxn
What blood level do we expect to see elevated in a patient with gout? Correct Ans-Uric acid
First line Tx for gout Correct Ans-Corticosteroids, NSAIDs, or Colchicine
What is the typical treatment regimen for chronic gout? Correct Ans-Allopurinol, Febuxostat,
low dose Colchicine (prophylaxis)
MOA of febuxostat Correct Ans-inhibits xanthine oxidase ->decreased production of uric acid
Is allopurinol safe to use with patient who have renal dysfunction? Correct Ans-Yes; Rx of
choice for pts with renal dysfxn or who overproduce uric acid
What is the initial dosage of colchicine for acute gout? Correct Ans-0.6mg TID on 1st day
,OR
1.2mg x 1 -> 0.6mgx1 in 1 hour; on subsequent days, 1-2/day until flare resolution
What is required to diagnose Osteoporosis? Correct Ans-DXA scan
T score of -2.5 or lower
T score of -1 to -2.5 PLUS one of the following:
10yr prob. of hip Frx of 3% or more OR
10 yr prob of osteoperosis r/t frx of 20% or more
What is the most common fracture seen in Severe Osteoporosis? Correct Ans-Hip & Vertebrae
What is the first-line treatment of osteoporosis? Correct Ans-Bisphosphonates with calcium
and vitamin D supplementation.
, Bisphophosphonates- examples Correct Ans-Alendronate, ibandronate, risedronate,
zolendronic acid
"-dronate"
"-dron-"
Pt education for bisphosphonates Correct Ans-Swallow tab whole
take with full glass of H2O
remain upright for at least 30min (60min for ibandronate)
Take medication on empty stomach
Possible AEs of bisphosphonates Correct Ans-Esophagitis, osteonecrosis of the jaw, & hip frx
MOA of bisphosphonates Correct Ans-Inhibits osteoclast bone resorption
Black box warning for Raloxifene Correct Ans-Increased risk for VTE
Increased risk for death from stroke in PM women with Hx or risk of CAD
