Top 500 drugs CPJE Questions with
Complete Solutions
Ofloxacin Correct Ans-Ocuflox, Floxin Otic
IV: PO Correct Ans-minocycline, doxycycline 1:1
moxifloxacin, levofloxacin 1:1
*** Tetracycline--> No IV
Metronidazole Correct Ans-Flagyl
- Mild-moderate CDI: 500 mg IV/PO TID for 10-14 days
- no renal adjustment
- take IR tabs w/ food***
- Take ER tabs on empty stomach
- metallic taste---No alcohol 3 days after discontinuation
- Indication: bacterial vaginosis, trichomoniasis, giardiasis, amebiasis, C. Difficile, intra-
abdominal infections.
-----Does not cover UTI, CAP
,***CI: 1st trimester in pregnancy (except for trichomoniasis)
**** Tinidazole (Tindamax) limited to protozoa (giardiasis, amebiasis), trichomoniasis, bacterial
vaginosis organisms.
Fosfomycin Correct Ans-Monurol
Urinary antiinfective
used in females only
3g X1 mixed w/ 3-4 oz of water
Rifaximin (Xifaxan) Correct Ans-- TD-- 200mg PO TID X 3days
- hepatic encephalopathy recurrence 550mg PO BID
- IBS -D 550 mg PO TID x 14 days
Pseudomonas aeruginosa coverage Correct Ans-Zosyn
cefepime (Maxipime)
,ceftazidime (Fortaz, Tazicef)
ceftazidime/avibactam (Avycaz)
ceftolozane/Tazobactam (Zerbaxa)
Carbapenems (except ertapenem)
Ciprofloxacin, Levofloxacin
Aztreonam (Azactam)
AGs
Colistimethate, Polymyxin B
Carbapenem-resistant Enterobacteriaceae (CRE) Correct Ans-Ceftazidime/Avibactam
Colistimethate, Polymyxin B
B. fragilis Correct Ans-Metronidazole
Beta-lactam/beta lactamase inhibitor
cefotetan, Cefoxitin
carbapenems
Tigecycline
, Acute bacterial meningitis tx Correct Ans-- dexamethasone is given 15-20 min prior to or w/
1st dose of Abx to prevent neurological complications of meningitis.
- Dexamethasone dose : 0.15 mg/kg IV Q6H x4day
-----3 drug options, Ampicilin, Vanco and ceftriaxone
if severe PCN allergy --> Quinolone (moxifloxacin or levofloxacin) + vancomycin
+/- bactrim 10-20 mg/kg day IV divided Q6-12 hrs for listeria coverage
*** bactrim for ampicilin
**** FQ for ceftriaxone
Acute Otitis Media (AOM) Correct Ans-1st line: amoxicillin or Augmentin
Alternative if PCN allergy --> Cefdinir or cefuroxime, ceftriaxone
TB Correct Ans-Active TB
- RIPE x 2months --> intensive phase
- continue INH and RIF QD or 3x Wk (18 weeks)--> continuation phase
--> total duration 26 weeks (6 months)
Complete Solutions
Ofloxacin Correct Ans-Ocuflox, Floxin Otic
IV: PO Correct Ans-minocycline, doxycycline 1:1
moxifloxacin, levofloxacin 1:1
*** Tetracycline--> No IV
Metronidazole Correct Ans-Flagyl
- Mild-moderate CDI: 500 mg IV/PO TID for 10-14 days
- no renal adjustment
- take IR tabs w/ food***
- Take ER tabs on empty stomach
- metallic taste---No alcohol 3 days after discontinuation
- Indication: bacterial vaginosis, trichomoniasis, giardiasis, amebiasis, C. Difficile, intra-
abdominal infections.
-----Does not cover UTI, CAP
,***CI: 1st trimester in pregnancy (except for trichomoniasis)
**** Tinidazole (Tindamax) limited to protozoa (giardiasis, amebiasis), trichomoniasis, bacterial
vaginosis organisms.
Fosfomycin Correct Ans-Monurol
Urinary antiinfective
used in females only
3g X1 mixed w/ 3-4 oz of water
Rifaximin (Xifaxan) Correct Ans-- TD-- 200mg PO TID X 3days
- hepatic encephalopathy recurrence 550mg PO BID
- IBS -D 550 mg PO TID x 14 days
Pseudomonas aeruginosa coverage Correct Ans-Zosyn
cefepime (Maxipime)
,ceftazidime (Fortaz, Tazicef)
ceftazidime/avibactam (Avycaz)
ceftolozane/Tazobactam (Zerbaxa)
Carbapenems (except ertapenem)
Ciprofloxacin, Levofloxacin
Aztreonam (Azactam)
AGs
Colistimethate, Polymyxin B
Carbapenem-resistant Enterobacteriaceae (CRE) Correct Ans-Ceftazidime/Avibactam
Colistimethate, Polymyxin B
B. fragilis Correct Ans-Metronidazole
Beta-lactam/beta lactamase inhibitor
cefotetan, Cefoxitin
carbapenems
Tigecycline
, Acute bacterial meningitis tx Correct Ans-- dexamethasone is given 15-20 min prior to or w/
1st dose of Abx to prevent neurological complications of meningitis.
- Dexamethasone dose : 0.15 mg/kg IV Q6H x4day
-----3 drug options, Ampicilin, Vanco and ceftriaxone
if severe PCN allergy --> Quinolone (moxifloxacin or levofloxacin) + vancomycin
+/- bactrim 10-20 mg/kg day IV divided Q6-12 hrs for listeria coverage
*** bactrim for ampicilin
**** FQ for ceftriaxone
Acute Otitis Media (AOM) Correct Ans-1st line: amoxicillin or Augmentin
Alternative if PCN allergy --> Cefdinir or cefuroxime, ceftriaxone
TB Correct Ans-Active TB
- RIPE x 2months --> intensive phase
- continue INH and RIF QD or 3x Wk (18 weeks)--> continuation phase
--> total duration 26 weeks (6 months)
