COMSAE 110 h
1. Childhood vaccines: Birth: Hep B h h h h
*Birth = Hep B h h h
2. Childhood vaccines: 2mo: Hep B h h h h
DTaP
h
PCV
RV
h
Polio
Hib
h
3. Childhood vaccines: 4mo: DTaP h h h
PCV
h
RV
Polio
Hib
h
*same as 2mo except Hep B
h h h h h
4. Childhood vaccines: 6mo: Hep B h h h h
DTaP
h
PCV
RV
h
Polio
Hib
h
flu
h
*same as 2mo h h
5. Childhood vaccines: 12-18mo: DTaPh h h
PCV
h
Hib
MM
h
R
Varicella
Hep A
h h
flu
h
6. Childhood vaccines: 4-6yo: DTaP h h h
Polio
h
MMR
Varicella
flu
h
7. Dx of fibromyalgia: Tenderness in at least 11/18 trigger points
h h h h h h h h h
Dx of exclusion
h h h
, COMSAE 110 h
8. Which is the best predictor for good outcome? h h h h h h h
a. daily walking h
b. smoking cessation: b. smoking cessation h h h h
9. Karyotype for complete mole: 46 XX h h h h h
-enucleated egg + single sperm (double paternal DNA) h h h h h h h
10. Karyotype for partial mole: 69 XXX h h h h h
-2 sperm + 1 egg
h h h h
-p57 positive
h
11. Give 4 antihypertensives that are safe during pregnancy: Hydralazine
h h h h h h h h
Methyldopa
h
Labetalol
Nifedipin
h
e
12. Give 2 inflammatory processes of benign breast disease: Fat necrosis
h h h h h h h h h
Lactational mastitis
h h
13. Fat necrosis of the breast: Painless lump due to trauma
h h h h h h h h h
Calcified oil cyst on mammography
h h h h h
14. Lactational mastitis: Breastfeeding h h
S. aureus
h
15. Give 3 benign breast tumors: Fibroadenoma
h h h h h
Intraductal papilloma
h h
Phyllodes tumor h
16. Fibroadenoma: F <35 h h
Small, mobile mass
h h h
Made of fibrous tissue & glands Inc
h h h h h h
size & tenderness w/ estrogen
h h h h h
17. Intraductal papilloma: Fibroepithelial tumor in lactiferous duc ts h h h h h h
Usually beneath areola
h h h
Most common cause of nipple discharge (bloody or serous)
h h h h h h h h
18. Phyllodes tumor: Large mass of CT w/ "leaflike" lobulated cy sts h h h h h h h h h
5th decade
h h
May become malignant
h h
19. Breast cancer is often due to overexpression of: estrogen/progesterone
h h h h h h h h
receptors or HER2
h h h
-triple negative (ER, PR, & HER2 neg = more aggressive)
h h h h h h h h h
, COMSAE 110 h
20. Give 3 noninvasive breast carcinomas: Ductal carcinoma in situ
h h h h h h h h
Paget disease
h h
Lobular carcinoma in situ h h h
21. Ductal carcinoma in situ: h h h
gross morphology (2) h h
micro morphology (2) h h
penetrates the basement mem?
h h h h
subtype (1): Gross: fills duct lumen & engorged blood vessels
h h h h h h h h h
Micro: ductal atypia & microcalcifications on mammography
h h h h h h h
Does NOT penetrate basement membrane
h h h h h
Subtype = comedocarcinoma h h
22. Comedocarcinoma: DCIS w/ central necrosis & dystrophic cal cification h h h h h h h
23. Paget disease: Extension of DCIS up lactiferous ducts & into ski n of nipple
h h h h h h h h h h h h
-eczematous patches over nipple & areola h h h h h
-Paget cells = intraepithelial adenocarcinoma cells (large cells surrou nded by clear
h h h h h h h h h h
halo)
h
24. Lobular carcinoma in situ: h h h
genetics
mass & calcifications? h h
risk of cancer?: Genetics: dec E-cadherin
h h h h h
No mass or calcifications (Incidental finding on biopsy)
h h h h h h h
Inc risk of cancer
h h h h
25. Give 4 invasive breast carcinomas: invasive ductal
h h h h h h
Invasive lobular
h h
Medullary
Inflammatory
h
26. Invasive ductal carcinoma: h h
gross morphology h
micro morphology: Most common invasive breast cancer
h h h h h h
Gross: firm, fibrous "rock hard" mass
h h h h h h
Micro: glandular, ductlike cells in desmoplastic stroma
h h h h h h
27. Invasive lobular carcinoma: h h
genetics
micro morphology h
BL or UL: Genetics: dec E-cadherin
h h h h h
Micro: orderly row of cells, NO duct formation, lacks desmoplastic response
h h h h h h h h h h
1. Childhood vaccines: Birth: Hep B h h h h
*Birth = Hep B h h h
2. Childhood vaccines: 2mo: Hep B h h h h
DTaP
h
PCV
RV
h
Polio
Hib
h
3. Childhood vaccines: 4mo: DTaP h h h
PCV
h
RV
Polio
Hib
h
*same as 2mo except Hep B
h h h h h
4. Childhood vaccines: 6mo: Hep B h h h h
DTaP
h
PCV
RV
h
Polio
Hib
h
flu
h
*same as 2mo h h
5. Childhood vaccines: 12-18mo: DTaPh h h
PCV
h
Hib
MM
h
R
Varicella
Hep A
h h
flu
h
6. Childhood vaccines: 4-6yo: DTaP h h h
Polio
h
MMR
Varicella
flu
h
7. Dx of fibromyalgia: Tenderness in at least 11/18 trigger points
h h h h h h h h h
Dx of exclusion
h h h
, COMSAE 110 h
8. Which is the best predictor for good outcome? h h h h h h h
a. daily walking h
b. smoking cessation: b. smoking cessation h h h h
9. Karyotype for complete mole: 46 XX h h h h h
-enucleated egg + single sperm (double paternal DNA) h h h h h h h
10. Karyotype for partial mole: 69 XXX h h h h h
-2 sperm + 1 egg
h h h h
-p57 positive
h
11. Give 4 antihypertensives that are safe during pregnancy: Hydralazine
h h h h h h h h
Methyldopa
h
Labetalol
Nifedipin
h
e
12. Give 2 inflammatory processes of benign breast disease: Fat necrosis
h h h h h h h h h
Lactational mastitis
h h
13. Fat necrosis of the breast: Painless lump due to trauma
h h h h h h h h h
Calcified oil cyst on mammography
h h h h h
14. Lactational mastitis: Breastfeeding h h
S. aureus
h
15. Give 3 benign breast tumors: Fibroadenoma
h h h h h
Intraductal papilloma
h h
Phyllodes tumor h
16. Fibroadenoma: F <35 h h
Small, mobile mass
h h h
Made of fibrous tissue & glands Inc
h h h h h h
size & tenderness w/ estrogen
h h h h h
17. Intraductal papilloma: Fibroepithelial tumor in lactiferous duc ts h h h h h h
Usually beneath areola
h h h
Most common cause of nipple discharge (bloody or serous)
h h h h h h h h
18. Phyllodes tumor: Large mass of CT w/ "leaflike" lobulated cy sts h h h h h h h h h
5th decade
h h
May become malignant
h h
19. Breast cancer is often due to overexpression of: estrogen/progesterone
h h h h h h h h
receptors or HER2
h h h
-triple negative (ER, PR, & HER2 neg = more aggressive)
h h h h h h h h h
, COMSAE 110 h
20. Give 3 noninvasive breast carcinomas: Ductal carcinoma in situ
h h h h h h h h
Paget disease
h h
Lobular carcinoma in situ h h h
21. Ductal carcinoma in situ: h h h
gross morphology (2) h h
micro morphology (2) h h
penetrates the basement mem?
h h h h
subtype (1): Gross: fills duct lumen & engorged blood vessels
h h h h h h h h h
Micro: ductal atypia & microcalcifications on mammography
h h h h h h h
Does NOT penetrate basement membrane
h h h h h
Subtype = comedocarcinoma h h
22. Comedocarcinoma: DCIS w/ central necrosis & dystrophic cal cification h h h h h h h
23. Paget disease: Extension of DCIS up lactiferous ducts & into ski n of nipple
h h h h h h h h h h h h
-eczematous patches over nipple & areola h h h h h
-Paget cells = intraepithelial adenocarcinoma cells (large cells surrou nded by clear
h h h h h h h h h h
halo)
h
24. Lobular carcinoma in situ: h h h
genetics
mass & calcifications? h h
risk of cancer?: Genetics: dec E-cadherin
h h h h h
No mass or calcifications (Incidental finding on biopsy)
h h h h h h h
Inc risk of cancer
h h h h
25. Give 4 invasive breast carcinomas: invasive ductal
h h h h h h
Invasive lobular
h h
Medullary
Inflammatory
h
26. Invasive ductal carcinoma: h h
gross morphology h
micro morphology: Most common invasive breast cancer
h h h h h h
Gross: firm, fibrous "rock hard" mass
h h h h h h
Micro: glandular, ductlike cells in desmoplastic stroma
h h h h h h
27. Invasive lobular carcinoma: h h
genetics
micro morphology h
BL or UL: Genetics: dec E-cadherin
h h h h h
Micro: orderly row of cells, NO duct formation, lacks desmoplastic response
h h h h h h h h h h
