CANNABINOÏDE ALS
PIJNSTILLER BIJ KANKER
Critically Appraised Topic
, Inhoud
A critically appraised topic...................................................................................................2
1. PI(C)O vraag...............................................................................................................2
2. In- en exclusiecriteria...................................................................................................2
3. Zoekopdracht..............................................................................................................2
4. Stroomdiagram............................................................................................................2
5. Gekozen artikel...........................................................................................................3
6. Kwaliteitsbeoordeling artikel..........................................................................................3
7. Klinische relevantie......................................................................................................5
8. Conclusie....................................................................................................................5
Bijlage 1: Artikel................................................................................................................6
Pharmacotherapeutic considerations for use of cannabinoids to relieve pain in patients with
malignant diseases..........................................................................................................6
Abstract.........................................................................................................................6
Purpose..........................................................................................................................6
Methods.........................................................................................................................6
Results...........................................................................................................................6
Conclusion......................................................................................................................6
Introduction....................................................................................................................7
Mechanism of action of cannabinoids...............................................................................7
Available cannabinoid analgesic agents............................................................................8
Approved ongoing clinical trials.......................................................................................8
Methods.........................................................................................................................8
Selection criteria...........................................................................................................9
Review of relevant research.............................................................................................11
Double-blind, 2-week, multicenter RCT, placebo-controlled study.......................................11
Extension of the main double-blind, 2-week, multicenter RCT, placebo-controlled study........11
Multicenter, double-blind, placebo-controlled RCT, three different doses of Sativex...............12
Discussion....................................................................................................................12
Conclusion....................................................................................................................13
Footnotes.....................................................................................................................14
References....................................................................................................................14
Bijlage 2: Beoordelingsformulier CAT...................................................................................17
1
PIJNSTILLER BIJ KANKER
Critically Appraised Topic
, Inhoud
A critically appraised topic...................................................................................................2
1. PI(C)O vraag...............................................................................................................2
2. In- en exclusiecriteria...................................................................................................2
3. Zoekopdracht..............................................................................................................2
4. Stroomdiagram............................................................................................................2
5. Gekozen artikel...........................................................................................................3
6. Kwaliteitsbeoordeling artikel..........................................................................................3
7. Klinische relevantie......................................................................................................5
8. Conclusie....................................................................................................................5
Bijlage 1: Artikel................................................................................................................6
Pharmacotherapeutic considerations for use of cannabinoids to relieve pain in patients with
malignant diseases..........................................................................................................6
Abstract.........................................................................................................................6
Purpose..........................................................................................................................6
Methods.........................................................................................................................6
Results...........................................................................................................................6
Conclusion......................................................................................................................6
Introduction....................................................................................................................7
Mechanism of action of cannabinoids...............................................................................7
Available cannabinoid analgesic agents............................................................................8
Approved ongoing clinical trials.......................................................................................8
Methods.........................................................................................................................8
Selection criteria...........................................................................................................9
Review of relevant research.............................................................................................11
Double-blind, 2-week, multicenter RCT, placebo-controlled study.......................................11
Extension of the main double-blind, 2-week, multicenter RCT, placebo-controlled study........11
Multicenter, double-blind, placebo-controlled RCT, three different doses of Sativex...............12
Discussion....................................................................................................................12
Conclusion....................................................................................................................13
Footnotes.....................................................................................................................14
References....................................................................................................................14
Bijlage 2: Beoordelingsformulier CAT...................................................................................17
1
