,DOWNLOADgTHEgTestgBankgforgCellulargandgMoleculargImmunologyg10th
gEditiongAbbas
Abbas,gLichtman,gandgPillai:gCellulargandgMoleculargImmunology,g10thg
Edition
TestgBank
Chapterg2:gCellsgandgTissuesgofgthegImmunegSystemgMa
tching
Questionsg1-5
Matchgeachgofgthegdescriptionsgingquestionsg1-5gwithgthegappropriategnameg(A-
M)gofganganatomicgfeaturegofglymphoidgtissues.
A. Periarteriolarglymphoidgsheath
B. Thymicgmedulla
C. Thymicgcortex
D. Parafolliculargcortexgofglymphgnode
E. Hematopoieticgbonegmarrow
F. Afferentglymphatic
G. Efferentglymphatic
H. Marginalgzone
I. Redgpulpgofgspleen
J. Whitegpulpgofgspleen
K. Epidermis
L. Dermis
M. Peyer’sgpatch
1. LocationgofgmostgTglymphocytesgingthegspleen
ANS:gA.gThegperiarteriolarglymphoidgsheathgsurroundsgthegcentralgarteriesgingthegspleenga
ndgisgthegTgcellgzonegingthisgorgan.
2. Vesselsgthatgdrainglymphgawaygfromgaglymphgnode
ANS:gG.gEfferentglymphaticgvesselsgdrainglymphgawaygfromglymphgnodes;gafferentgvessel
sgdrainglymphgintoglymphgnodes.
3. SitegofgleastgmaturegTgcellgprecursorsgingthegthymus
ANS:gC.gBonegmarrow–
derivedgTgcellgprecursorsgfirstgentergthegthymicgcortexgandgmigrategintog thegmedullagasgt
heygbecomegmoregmature.
4. LocationgofgLangerhansgcells
ANS:gK.gLangerhansgcellsgaregdendriticgcellsgingthegepidermisgofgthegskingthatgdevelopgfromgfetal
gmacrophages.
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5. Lymphoidgaggregategofgthegmucosalgimmunegsystem
ANS:gM.gPeyer’sgpatchesgaregBgcell–
richglymphoidgaggregatesglocatedgingthegsubmucosagofgthegsmallgintestine.
MultiplegChoice
6. Whichgofgthegfollowinggisgtheggenerativeg(primary)glymphoidgorgangforgTglymphocytes?
A. Bonegmarrow
B. Spleen
C. Lymphgnode
D. Thymus
E. Tonsil
ANS:gD.gGenerativeg(primary)glymphoidgorgansgaregthegorgansgwhereglymphocytesgfirstge
xpressgantigengreceptorsgandgattaingfunctionalgmaturity.gAlthoughgTgcellgprecursorsgarisegi
ngthegbonegmarrow,gthesegprecursorsgmigrategtogthegthymus,gwheregmaturationgtakesgplace
.gIngcontrast,gBgcellsgmaturegingthegbonegmarrow.gSpleen,glymphgnode,gandgtonsilgaregsec
ondaryglymphoidgorgansgpopulatedgbygmaturegBgandgTgcells.
7. Whichgofgthegfollowinggstatementsgaboutgtissue-residentgmacrophagesgisgcorrect?
A. Theygaregallgderivedgfromgbloodgmonocytesgthatgentergtissuesgduringginfections
B. Manygofgthesegcellsgfirstgpopulategtissuesgduringgfetalgdevelopment
C. Theygdifferentiategfromgdifferentgkindsgofgepithelialgcellsgingeachgtissue
D. Theygconstantlygrecirculategbetweengdifferentgtissues
E. Theygaregprofessionalgantigen-
presentinggcellsgthatgactivategnaivegTgcellsgthatgmigrategintogtissues
ANS:gB.gManygtissue-
residentgmacrophagesgaregderivedgfromgfetalgyolkgsacgandgfetalglivergprecursorsgandgestabl
ishgresidencegingthegdifferentgtissuesgduringgfetalgdevelopment.gOthergtissue-
gresidentgmacrophagesgaregderivedgfromgbonegmarrow–
derivedgbloodgmonocytesgthatgentergtissuesgundergnormalgconditionsgorgduringginfections.g
Epithelialgcellsgdognotgdifferentiategintogmacrophages.gOncegingthegtissue,gtissue-
residentgmacrophagesgcellsgdognotgleavegtogrecirculate.gNaivegTgcellsgdognotgusuallygenter
gnon-lymphoidgtissues,gandgtissue-
residentgmacrophagesghavegnogrolegingpresentinggantigengtognaivegTgcells.
8. Whichgtypegofgleukocytegisgthegmostgabundantgingthegbloodgofgaghealthygadult?
A. Monocytes
B. Bglymphocytes
C. Tglymphocytes
D. Polymorphonucleargleukocytes
E. Basophils
Copyrightg©g2022gElseviergInc.gAllgrightsgreser 2
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gEditiongAbbas
ANS:gD.gPolymorphonucleargleukocytesg(orgneutrophils)garegthegmostgabundantgbloodgleuk
ocyteg(~g4,000/mm3),gaboutgtwicegthegnumbergofgBgandgTglymphocytesgcombined.
9. Whichgofgthegfollowinggisgagfeaturegofgfibroblasticgreticulargcellsg(FRCs)?
A. Theyglinegtheglumensgofglymphaticsgenteringglymphgnodes
B. Theygaregderivedgfromghematopoieticgprecursors
C. Theygplaygagcriticalgrolegingestablishinggwhereglymphocytesgareglocatedginglymphgnodes
D. TheygsecretegcytokinesgthatgstimulategTgcellgproliferation
E. Theygaregphagocyticgcellsgofginnategimmunitygthatgkillgmicrobes
ANS:gC.gFRCsgaregmesenchymal-derivedg(notghaematopoietically-
derived)gcellsgwithgpropertiesgofgmusclegandgfibroblastg(myofibroblasts)gthatgdrivegformati
ongofgsecondaryglymphoidgorgansgduringgembryonicgdevelopmentgandgcontributegtogthegan
atomicgsegregationgandgmovementgofglymphocytesgandgdendriticgcellsgingsecondaryglymph
oidgorgans.gTheygaregnotgphagocytic,ghavegnogdirectgantimicrobialgeffectorgfunctions,gdogn
otgsecretegIL-2gorgothergTgcellggrowthgfactors,gandgdognotglineglumensgofglymphatics.
10. Whichg typeg ofg cellg isg mostg importantg ing capturingg proteing antigensg ofg microbesg th
atg entergthroughgepithelialgbarriersgandgpresentinggthemgtognaivegTgcellsgingsecondarygly
mphoidgorgans?
A. Classicalgdendriticgcells
B. Plasmacytoidgdendriticgcells
C. Plasmagcells
D. Macrophages
E. Folliculargdendriticgcells
ANS:gA.gClassicalg(orgconventional)gdendriticgcellsg(DCs)garegthegmaingcellgtypegthatgbri
ngsgmicrobialgantigensgfromginfectedgtissuesgintogdrainingglymphgnodesgandgpresentsgpepti
desgderivedgfromgthesegantigensgtognaivegTgcellsgthatgcirculategthoughgtheglymphgnodes.g
PlasmacytoidgDCsgsecretegtypeg1ginterferonsgingresponsegtogviralginfection.gPlasmagcellsga
regantibody-
secretinggcellsgderivedgfromgBgcellsgandgdognotgpresentgantigengtogTgcells.gMacrophagesg
cangpresentgantigengtogeffectorgTgcells,gbutgtheygaregnotgefficientgactivatorsgofgnaivegTgce
lls.gFolliculargdendriticgcellsgdisplaygantigensgtogBgcellsgonglymphoidgfollicles.
Copyrightg©g2022gElseviergInc.gAllgrightsgreser 3
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gEditiongAbbas
Abbas,gLichtman,gandgPillai:gCellulargandgMoleculargImmunology,g10thg
Edition
TestgBank
Chapterg2:gCellsgandgTissuesgofgthegImmunegSystemgMa
tching
Questionsg1-5
Matchgeachgofgthegdescriptionsgingquestionsg1-5gwithgthegappropriategnameg(A-
M)gofganganatomicgfeaturegofglymphoidgtissues.
A. Periarteriolarglymphoidgsheath
B. Thymicgmedulla
C. Thymicgcortex
D. Parafolliculargcortexgofglymphgnode
E. Hematopoieticgbonegmarrow
F. Afferentglymphatic
G. Efferentglymphatic
H. Marginalgzone
I. Redgpulpgofgspleen
J. Whitegpulpgofgspleen
K. Epidermis
L. Dermis
M. Peyer’sgpatch
1. LocationgofgmostgTglymphocytesgingthegspleen
ANS:gA.gThegperiarteriolarglymphoidgsheathgsurroundsgthegcentralgarteriesgingthegspleenga
ndgisgthegTgcellgzonegingthisgorgan.
2. Vesselsgthatgdrainglymphgawaygfromgaglymphgnode
ANS:gG.gEfferentglymphaticgvesselsgdrainglymphgawaygfromglymphgnodes;gafferentgvessel
sgdrainglymphgintoglymphgnodes.
3. SitegofgleastgmaturegTgcellgprecursorsgingthegthymus
ANS:gC.gBonegmarrow–
derivedgTgcellgprecursorsgfirstgentergthegthymicgcortexgandgmigrategintog thegmedullagasgt
heygbecomegmoregmature.
4. LocationgofgLangerhansgcells
ANS:gK.gLangerhansgcellsgaregdendriticgcellsgingthegepidermisgofgthegskingthatgdevelopgfromgfetal
gmacrophages.
Copyrightg©g2022gElseviergInc.gAllgrightsgreser 1
ved.
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gEditiongAbbas
5. Lymphoidgaggregategofgthegmucosalgimmunegsystem
ANS:gM.gPeyer’sgpatchesgaregBgcell–
richglymphoidgaggregatesglocatedgingthegsubmucosagofgthegsmallgintestine.
MultiplegChoice
6. Whichgofgthegfollowinggisgtheggenerativeg(primary)glymphoidgorgangforgTglymphocytes?
A. Bonegmarrow
B. Spleen
C. Lymphgnode
D. Thymus
E. Tonsil
ANS:gD.gGenerativeg(primary)glymphoidgorgansgaregthegorgansgwhereglymphocytesgfirstge
xpressgantigengreceptorsgandgattaingfunctionalgmaturity.gAlthoughgTgcellgprecursorsgarisegi
ngthegbonegmarrow,gthesegprecursorsgmigrategtogthegthymus,gwheregmaturationgtakesgplace
.gIngcontrast,gBgcellsgmaturegingthegbonegmarrow.gSpleen,glymphgnode,gandgtonsilgaregsec
ondaryglymphoidgorgansgpopulatedgbygmaturegBgandgTgcells.
7. Whichgofgthegfollowinggstatementsgaboutgtissue-residentgmacrophagesgisgcorrect?
A. Theygaregallgderivedgfromgbloodgmonocytesgthatgentergtissuesgduringginfections
B. Manygofgthesegcellsgfirstgpopulategtissuesgduringgfetalgdevelopment
C. Theygdifferentiategfromgdifferentgkindsgofgepithelialgcellsgingeachgtissue
D. Theygconstantlygrecirculategbetweengdifferentgtissues
E. Theygaregprofessionalgantigen-
presentinggcellsgthatgactivategnaivegTgcellsgthatgmigrategintogtissues
ANS:gB.gManygtissue-
residentgmacrophagesgaregderivedgfromgfetalgyolkgsacgandgfetalglivergprecursorsgandgestabl
ishgresidencegingthegdifferentgtissuesgduringgfetalgdevelopment.gOthergtissue-
gresidentgmacrophagesgaregderivedgfromgbonegmarrow–
derivedgbloodgmonocytesgthatgentergtissuesgundergnormalgconditionsgorgduringginfections.g
Epithelialgcellsgdognotgdifferentiategintogmacrophages.gOncegingthegtissue,gtissue-
residentgmacrophagesgcellsgdognotgleavegtogrecirculate.gNaivegTgcellsgdognotgusuallygenter
gnon-lymphoidgtissues,gandgtissue-
residentgmacrophagesghavegnogrolegingpresentinggantigengtognaivegTgcells.
8. Whichgtypegofgleukocytegisgthegmostgabundantgingthegbloodgofgaghealthygadult?
A. Monocytes
B. Bglymphocytes
C. Tglymphocytes
D. Polymorphonucleargleukocytes
E. Basophils
Copyrightg©g2022gElseviergInc.gAllgrightsgreser 2
ved.
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, DOWNLOADgTHEgTestgBankgforgCellulargandgMoleculargImmunologyg10th
gEditiongAbbas
ANS:gD.gPolymorphonucleargleukocytesg(orgneutrophils)garegthegmostgabundantgbloodgleuk
ocyteg(~g4,000/mm3),gaboutgtwicegthegnumbergofgBgandgTglymphocytesgcombined.
9. Whichgofgthegfollowinggisgagfeaturegofgfibroblasticgreticulargcellsg(FRCs)?
A. Theyglinegtheglumensgofglymphaticsgenteringglymphgnodes
B. Theygaregderivedgfromghematopoieticgprecursors
C. Theygplaygagcriticalgrolegingestablishinggwhereglymphocytesgareglocatedginglymphgnodes
D. TheygsecretegcytokinesgthatgstimulategTgcellgproliferation
E. Theygaregphagocyticgcellsgofginnategimmunitygthatgkillgmicrobes
ANS:gC.gFRCsgaregmesenchymal-derivedg(notghaematopoietically-
derived)gcellsgwithgpropertiesgofgmusclegandgfibroblastg(myofibroblasts)gthatgdrivegformati
ongofgsecondaryglymphoidgorgansgduringgembryonicgdevelopmentgandgcontributegtogthegan
atomicgsegregationgandgmovementgofglymphocytesgandgdendriticgcellsgingsecondaryglymph
oidgorgans.gTheygaregnotgphagocytic,ghavegnogdirectgantimicrobialgeffectorgfunctions,gdogn
otgsecretegIL-2gorgothergTgcellggrowthgfactors,gandgdognotglineglumensgofglymphatics.
10. Whichg typeg ofg cellg isg mostg importantg ing capturingg proteing antigensg ofg microbesg th
atg entergthroughgepithelialgbarriersgandgpresentinggthemgtognaivegTgcellsgingsecondarygly
mphoidgorgans?
A. Classicalgdendriticgcells
B. Plasmacytoidgdendriticgcells
C. Plasmagcells
D. Macrophages
E. Folliculargdendriticgcells
ANS:gA.gClassicalg(orgconventional)gdendriticgcellsg(DCs)garegthegmaingcellgtypegthatgbri
ngsgmicrobialgantigensgfromginfectedgtissuesgintogdrainingglymphgnodesgandgpresentsgpepti
desgderivedgfromgthesegantigensgtognaivegTgcellsgthatgcirculategthoughgtheglymphgnodes.g
PlasmacytoidgDCsgsecretegtypeg1ginterferonsgingresponsegtogviralginfection.gPlasmagcellsga
regantibody-
secretinggcellsgderivedgfromgBgcellsgandgdognotgpresentgantigengtogTgcells.gMacrophagesg
cangpresentgantigengtogeffectorgTgcells,gbutgtheygaregnotgefficientgactivatorsgofgnaivegTgce
lls.gFolliculargdendriticgcellsgdisplaygantigensgtogBgcellsgonglymphoidgfollicles.
Copyrightg©g2022gElseviergInc.gAllgrightsgreser 3
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