Pharma Mid Sem With Correct Solutions!!
Definition of pharmacokinetics
The study of the movement of drugs into, within and out of the body and factors affecting
this
i.e. what the body does to the drug
What are the 4 factors relating to pharmacokinetics
Absorption
Distribution
Metabolism
Excretion/elimination
Why is pharmacokinetics important?
Attainment of a plasma concentration of drug that is in therapeutic range
- clinicians achieve this by using the correct route of administration, starting dose and
*frequency
What is the goal of drug therapy?
To achieve efficacy without toxicity
Absorption definition
, The ability of a drug to cross the gut wall into the portal vein
—> how does the drug get into the body
4 types of absorption
passive diffusion, facilitated diffusion, active transport (ATP), endocytosis
Factors affecting absorption
Blood flow
Solubility
Ionisation
Formulation
Nature of cell membrane
Therapeutic range
The minimum and maximum concentrations of a drug that achieve the objective of
arriving at the correct concentration of the drug in the plasma
Passive diffusion of drugs
1. Size (mw <500)
2. Lipid solubility
3. Ionisation
Definition of pharmacokinetics
The study of the movement of drugs into, within and out of the body and factors affecting
this
i.e. what the body does to the drug
What are the 4 factors relating to pharmacokinetics
Absorption
Distribution
Metabolism
Excretion/elimination
Why is pharmacokinetics important?
Attainment of a plasma concentration of drug that is in therapeutic range
- clinicians achieve this by using the correct route of administration, starting dose and
*frequency
What is the goal of drug therapy?
To achieve efficacy without toxicity
Absorption definition
, The ability of a drug to cross the gut wall into the portal vein
—> how does the drug get into the body
4 types of absorption
passive diffusion, facilitated diffusion, active transport (ATP), endocytosis
Factors affecting absorption
Blood flow
Solubility
Ionisation
Formulation
Nature of cell membrane
Therapeutic range
The minimum and maximum concentrations of a drug that achieve the objective of
arriving at the correct concentration of the drug in the plasma
Passive diffusion of drugs
1. Size (mw <500)
2. Lipid solubility
3. Ionisation
