PHRM 515 Exam 2 Study Guide With
Correct Solutions
dimethyl sulfoxide - ANSWER Universal solvent in pharma
changes keratin from a to b sheet
extracts lipids from corneum
ethanol - ANSWER most commonly used alcohol
extracts corneum lipids
Aerosol system - ANSWER container valve propellant
What is the most widely used container - ANSWER tin-plated steel
What are propellants? - ANSWER Compressed gases, liquefied gases
issue with compressed gases - ANSWER lose pressure over time
Benefit of HFA - ANSWER no impact on ozone layer
low toxicity
high stability
pure
ways to fill an aresol - ANSWER cold filling
pressure filling
What is a metered dose inhaler? - ANSWER most common aerosol
What is a dry powder inhalation good for - ANSWER large macro molecule
Why did exubera (inhaled insulin) fail - ANSWER too big too expensive not effective
Types of polymers - ANSWER Natural, Synthetic, Semi synthetic
natural polymers - ANSWER starch, cellulose, proteins
Synthetic polymers - ANSWER polymers that are made from petroleum products and are
long polymers
semi-synthetic polymers - ANSWER mostly derived from naturally occurring polymers by
, chemical modifications
Natural bio-degradable polymers - ANSWER Tend to be more impure and expensive
Synthetic bio-degradable polymers - ANSWER preferred
Linear polymers - ANSWER no branching or cross-links
branched polymer - ANSWER A polymer having a molecular structure of secondary
chains that extend from the primary main chains.
3 or more functional groups
Polymerization - ANSWER joining monomers to form a polymer
initiator - ANSWER relatively unstable and decomposes into a free radical
propagation - ANSWER middle step in chain polymerization monomers are attached
Termination - ANSWER reaction ended propagation of chain
combination - ANSWER two growing chains join together and stop
Disproportion - ANSWER when a double bond forms from the free radical reacting with a
hydrogen or a impurity
homopolymer - ANSWER all the same monomer
copolymer - ANSWER more than one kind of polymer
random copolymer - ANSWER A polymer in which two different repeat units are
randomly distributed along the molecular chain.
alternating copolymer - ANSWER A and B alternate in polymer chain
block copolymer - ANSWER A linear copolymer in which identical repeat units are
clustered in blocks along the molecular chain.
graft polymer - ANSWER homopolymer side branches joined to main chains to compose
an entirely different repeat unit
Glass transition temperature - ANSWER temp at which an amorphous polymer
transitions from a glass to a soft material
Melting temperature - ANSWER temp at which a crystalline polymer melts
Criteria for polymer selection - ANSWER easy to make
finite weight
provide drug attachment and release sites
Correct Solutions
dimethyl sulfoxide - ANSWER Universal solvent in pharma
changes keratin from a to b sheet
extracts lipids from corneum
ethanol - ANSWER most commonly used alcohol
extracts corneum lipids
Aerosol system - ANSWER container valve propellant
What is the most widely used container - ANSWER tin-plated steel
What are propellants? - ANSWER Compressed gases, liquefied gases
issue with compressed gases - ANSWER lose pressure over time
Benefit of HFA - ANSWER no impact on ozone layer
low toxicity
high stability
pure
ways to fill an aresol - ANSWER cold filling
pressure filling
What is a metered dose inhaler? - ANSWER most common aerosol
What is a dry powder inhalation good for - ANSWER large macro molecule
Why did exubera (inhaled insulin) fail - ANSWER too big too expensive not effective
Types of polymers - ANSWER Natural, Synthetic, Semi synthetic
natural polymers - ANSWER starch, cellulose, proteins
Synthetic polymers - ANSWER polymers that are made from petroleum products and are
long polymers
semi-synthetic polymers - ANSWER mostly derived from naturally occurring polymers by
, chemical modifications
Natural bio-degradable polymers - ANSWER Tend to be more impure and expensive
Synthetic bio-degradable polymers - ANSWER preferred
Linear polymers - ANSWER no branching or cross-links
branched polymer - ANSWER A polymer having a molecular structure of secondary
chains that extend from the primary main chains.
3 or more functional groups
Polymerization - ANSWER joining monomers to form a polymer
initiator - ANSWER relatively unstable and decomposes into a free radical
propagation - ANSWER middle step in chain polymerization monomers are attached
Termination - ANSWER reaction ended propagation of chain
combination - ANSWER two growing chains join together and stop
Disproportion - ANSWER when a double bond forms from the free radical reacting with a
hydrogen or a impurity
homopolymer - ANSWER all the same monomer
copolymer - ANSWER more than one kind of polymer
random copolymer - ANSWER A polymer in which two different repeat units are
randomly distributed along the molecular chain.
alternating copolymer - ANSWER A and B alternate in polymer chain
block copolymer - ANSWER A linear copolymer in which identical repeat units are
clustered in blocks along the molecular chain.
graft polymer - ANSWER homopolymer side branches joined to main chains to compose
an entirely different repeat unit
Glass transition temperature - ANSWER temp at which an amorphous polymer
transitions from a glass to a soft material
Melting temperature - ANSWER temp at which a crystalline polymer melts
Criteria for polymer selection - ANSWER easy to make
finite weight
provide drug attachment and release sites
