PATHOPHYSIOLOGY
THEBIOLOGICBASISFORDISEASEINADULTSANDCHILDREN
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8thEdition
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KathrynL.McCance,SueE.Huether
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Contents
Chapter01:CellularBiology ............................................................................................................................. 4
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Chapter02:Altered CellularandTissueBiology:Environmental Agents ........................................................... 18
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Chapter03:TheCellularEnvironment:Fluids andElectrolytes, AcidsandBases ................................................ 31
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Chapter04:GenesandGeneticDiseases ......................................................................................................... 44
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Chapter05:Genes, Environment-Lifestyle,andCommon Diseases ................................................................. 55
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Chapter06:EpigeneticsandDisease .............................................................................................................. 63
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Chapter07:InnateImmunity:InflammationandWoundHealing ..................................................................... 68
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Chapter08:Adaptive Immunity ..................................................................................................................... 83
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Chapter09:AlterationsinImmunity andInflammation ................................................................................... 95
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Chapter10:Infection................................................................................................................................... 108
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Chapter11:StressandDisease ..................................................................................................................... 117
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Chapter12:CancerBiology .......................................................................................................................... 124
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Chapter13:CancerEpidemiology ................................................................................................................ 137
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Chapter14:CancerinChildren ..................................................................................................................... 143
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Chapter15:Structure andFunction oftheNeurologicSystem........................................................................ 148
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Chapter16:Pain,Temperature Regulation,Sleep, andSensory Function ....................................................... 159
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Chapter17:AlterationsinCognitive Systems,Cerebral Hemodynamics,and Motor Function ........................ 174
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Chapter18:Disordersofthe CentralandPeripheral Nervous Systemsandthe Neuromuscular Junction
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................................................................................................................................................................ 188
Chapter19:Neurobiologyof Schizophrenia,MoodDisorders,andAnxietyDisorders...................................... 199
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Chapter 20: Alterations ofNeurologicFunction inChildren ........................................................................... 206
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Chapter21:MechanismsofHormonalRegulation ....................................................................................... 213
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Chapter22:Alterations ofHormonalRegulation .......................................................................................... 222
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Chapter23:Obesity andDisordersofNutrition ............................................................................................. 234
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Chapter24:Structure andFunctionoftheReproductive Systems .................................................................. 239
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Chapter25:Alterationsofthe FemaleReproductive System ......................................................................... 249
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Chapter26:Alterationsofthe Male Reproductive System ............................................................................. 259
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Chapter27:Sexually Transmitted Infections ................................................................................................ 265
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Chapter28:Structure andFunction oftheHematologic System .................................................................... 273
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Chapter29:AlterationsofErythrocytes,Platelets, andHemostatic Function ................................................. 283
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Chapter30:AlterationsofLeukocyte andLymphoidFunction ........................................................................ 293
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Chapter31:AlterationsofHematologicFunctionin Children ......................................................................... 300
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Chapter32:Structure andFunctionoftheCardiovascular andLymphatic Systems ......................................... 311
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Chapter33:AlterationsofCardiovascular Function ...................................................................................... 324
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Chapter34:AlterationsofCardiovascular FunctioninChildren ...................................................................... 338
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Chapter35:StructureandFunctionofthePulmonary System ....................................................................... 346
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Chapter 36:Alterations ofPulmonary Function ........................................................................................... 356
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Chapter37:Alterations ofPulmonaryFunctioninChildren ........................................................................... 373
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Chapter38:Structure andFunctionoftheRenal andUrologic Systems ........................................................... 381
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Chapter 39:Alterations ofRenal andUrinaryTract Function .......................................................................... 391
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Chapter40:AlterationsofRenalandUrinaryTractFunctionin Children........................................................... 401
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Chapter41:StructureandFunctionoftheDigestiveSystem .......................................................................... 409
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Chapter42:AlterationsofDigestive Function ............................................................................................... 421
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Chapter43:AlterationsofDigestive FunctioninChildren ............................................................................... 432
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Chapter 44: Structure andFunctionoftheMusculoskeletal System .............................................................. 441
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Chapter45:AlterationsofMusculoskeletal Function .................................................................................... 453
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Chapter46:AlterationsofMusculoskeletal FunctioninChildren.................................................................... 466
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Chapter47:Structure, Function,andDisordersoftheIntegument ................................................................. 475
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Chapter48:Alterationsofthe Integumentin Children ................................................................................... 486
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Chapter49:Shock,MultipleOrganDysfunctionSyndrome, andBurnsinAdults .............................................. 494
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Chapter50:Shock,MultipleOrganDysfunctionSyndrome, andBurnsinChildren ........................................... 502
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, TestBank-Pathophysiology:TheBiologicBasisforDiseaseinAdultsandChildren(8th)
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Chapter01:CellularBiology p
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1. Whichstatementbestdescribesthecellularfunctionofmetabolicabsorption?
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a. Cellscanproduceproteins. z
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b. Cellscansecretedigestiveenzymes. z
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c. Cellscantakeinandusenutrients. z
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d. Cellscansynthesizefats. z
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ANS: C p z
Inmetabolicabsorption,allcellstakeinandusenutrientsandothersubstancesfromtheir
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surroundings. Theremainingoptions arenot inclusive in their descriptions of cellular
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metabolicabsorption.
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2. Whereismostofacell’sgeneticinformation,includingRNAandDNA,contained?
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a. Mitochondria
b. Ribosome
c. Nucleolus
d. Lysosome
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Thenucleuscontainsthenucleolus,asmalldensestructurecomposedlargelyofRNA,mosto fthe
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cellularDNA,andtheDNA-bindingproteins,suchasthehistones,whichregulateits activity.
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The mitochondria are responsible for cellular respiration and energyproduction.
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p Ribosomes’chieffunctionistoprovidesitesforcellularproteinsynthesis.Lysosomesfunctionas the
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intracellulardigestive system.
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3. Whichcomponentofthecellproduceshydrogenperoxide(H2O2)byusingoxygento
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a. Lysosomes
b. Peroxisomes
c. Ribosomes
d. Endosome
ANS: B p z