ANTIVIRAL AGENTS
Department of Pharmacology
,ANTIVIRAL AGENTS
VIRUSES:
❖Single or double stranded DNA or RNA enclosed in a protein – CAPSID
❖Obligate intracellular parasite
❖Replication depends on synthetic processes of the host cell
❖Antiviral drugs must either block entry or exit from cell or be active
inside the host cell
,VIRAL REPLICATION:
➢Adsorption and penetration into susceptible host cells
➢Uncoating of viral nucleic acid
➢Synthesis of early regulatory proteins
➢Synthesis of RNA or DNA
➢Synthesis of late regulatory proteins
➢Assembly (maturation) of viral particles
➢Release from cells
,
Department of Pharmacology
,ANTIVIRAL AGENTS
VIRUSES:
❖Single or double stranded DNA or RNA enclosed in a protein – CAPSID
❖Obligate intracellular parasite
❖Replication depends on synthetic processes of the host cell
❖Antiviral drugs must either block entry or exit from cell or be active
inside the host cell
,VIRAL REPLICATION:
➢Adsorption and penetration into susceptible host cells
➢Uncoating of viral nucleic acid
➢Synthesis of early regulatory proteins
➢Synthesis of RNA or DNA
➢Synthesis of late regulatory proteins
➢Assembly (maturation) of viral particles
➢Release from cells
,
