ACTIVE LEARNING TEMPLATE: Medication
Dyanne Hartley
STUDENT NAME _____________________________________
Chlordiazepoxide
MEDICATION __________________________________________________________________________ REVIEW MODULE CHAPTER ___________
Benzodiazepine
CATEGORY CLASS ______________________________________________________________________
PURPOSE OF MEDICATION
Expected Pharmacological Action Therapeutic Use
Acts on levels of the CNS to produce Sedation. Relief of anxiety
anxiolytic effect. Depression of the CNS,
by potentiating GABA inhibitory
neurotransmitters
Complications Medication Administration
CNS: dizziness, drowsiness, hangover, headache, mental depression, PO (Adults): Alcohol withdrawal—50– 100
paradoxical excitation, sedation. mg, repeated until agitation is controlled
EENT: blurred vision. (up to 400 mg/day). Anxiety—5– 25 mg 3– 4
GI:constipation, diarrhea, nausea, vomiting, weight gain. times daily. PO (Geriatric Patients or
Derm: rashes. Debilitated Patients): Anxiety—5 mg 2– 4
Misc: physical dependence, psychological dependence, tolerance times daily initially, increased as needed.
PO (Children 6 yr): Anxiety—5 mg 2– 4 times
daily, up to 10 mg 2– 3 times daily.
Contraindications/Precautions
Contraindicated in: Hypersensitivity; tartrazine should be avoided in patients with known
intolerance; Cross-sensitivity with other benzodiazepines may; Comatose patients
Use Cautiously in: Hepatic dysfunction; Severe renal impairment; History of suicide Nursing Interventions
attempt or substance abuse
Geri: Assess risk of falls and institute fall prevention strategies.
Geri: Long-acting benzodiazepines cause prolonged sedation in the elderly.
Alcohol Withdrawal: Assess for tremors, agitation, delirium, and
hallucinations. Protect patient from injury. Institute seizure
precautions.
Lab Test Considerations: Patients on prolonged
therapy should have CBC and liver function tests evaluated
periodically. May cause serum bilirubin, AST, and ALT.
Interactions Toxicity and Overdose: Flumazenil reverses sedation caused by
chlordiazepoxide toxicity or overdose. (Flumazenil may induce
seizures in patients with a history of seizure disorder or who are
Alcohol, antidepressants, antihistamines, and opioid analgesics— concurrent use on tricyclic antidepressants.)
results in additive CNS depression. Cimetidine, oral contraceptives, disulfiram,
fluoxetine, isoniazid, ketoconazole, metoprolol, propranolol, or valproic acid may
enhance effects. May decrease efficacy of levodopa. Rifampin or barbiturates may
decrease effectiveness of chlordiazepoxide. Sedative effects may be decreased by
theophylline, supplements like kava-kava, valerian and/or chamomile increase CNS
depression
Client Education
May cause drowsiness or dizziness.
Caution patient to avoid driving or other
activities until response to medication is
Evaluation of Medication Effectiveness known. Advise patient to avoid the use of
alcohol and other CNS depressants
Decreased sense of anxiety. concurrently with this medication. Instruct
Increased ability to cope. patient to notify health care professional if
Decreased delirium and tremors when used for alcohol pregnancy is planned or suspected, or if
withdrawal breast feeding.
ACTIVE LEARNING TEMPLATES
Dyanne Hartley
STUDENT NAME _____________________________________
Chlordiazepoxide
MEDICATION __________________________________________________________________________ REVIEW MODULE CHAPTER ___________
Benzodiazepine
CATEGORY CLASS ______________________________________________________________________
PURPOSE OF MEDICATION
Expected Pharmacological Action Therapeutic Use
Acts on levels of the CNS to produce Sedation. Relief of anxiety
anxiolytic effect. Depression of the CNS,
by potentiating GABA inhibitory
neurotransmitters
Complications Medication Administration
CNS: dizziness, drowsiness, hangover, headache, mental depression, PO (Adults): Alcohol withdrawal—50– 100
paradoxical excitation, sedation. mg, repeated until agitation is controlled
EENT: blurred vision. (up to 400 mg/day). Anxiety—5– 25 mg 3– 4
GI:constipation, diarrhea, nausea, vomiting, weight gain. times daily. PO (Geriatric Patients or
Derm: rashes. Debilitated Patients): Anxiety—5 mg 2– 4
Misc: physical dependence, psychological dependence, tolerance times daily initially, increased as needed.
PO (Children 6 yr): Anxiety—5 mg 2– 4 times
daily, up to 10 mg 2– 3 times daily.
Contraindications/Precautions
Contraindicated in: Hypersensitivity; tartrazine should be avoided in patients with known
intolerance; Cross-sensitivity with other benzodiazepines may; Comatose patients
Use Cautiously in: Hepatic dysfunction; Severe renal impairment; History of suicide Nursing Interventions
attempt or substance abuse
Geri: Assess risk of falls and institute fall prevention strategies.
Geri: Long-acting benzodiazepines cause prolonged sedation in the elderly.
Alcohol Withdrawal: Assess for tremors, agitation, delirium, and
hallucinations. Protect patient from injury. Institute seizure
precautions.
Lab Test Considerations: Patients on prolonged
therapy should have CBC and liver function tests evaluated
periodically. May cause serum bilirubin, AST, and ALT.
Interactions Toxicity and Overdose: Flumazenil reverses sedation caused by
chlordiazepoxide toxicity or overdose. (Flumazenil may induce
seizures in patients with a history of seizure disorder or who are
Alcohol, antidepressants, antihistamines, and opioid analgesics— concurrent use on tricyclic antidepressants.)
results in additive CNS depression. Cimetidine, oral contraceptives, disulfiram,
fluoxetine, isoniazid, ketoconazole, metoprolol, propranolol, or valproic acid may
enhance effects. May decrease efficacy of levodopa. Rifampin or barbiturates may
decrease effectiveness of chlordiazepoxide. Sedative effects may be decreased by
theophylline, supplements like kava-kava, valerian and/or chamomile increase CNS
depression
Client Education
May cause drowsiness or dizziness.
Caution patient to avoid driving or other
activities until response to medication is
Evaluation of Medication Effectiveness known. Advise patient to avoid the use of
alcohol and other CNS depressants
Decreased sense of anxiety. concurrently with this medication. Instruct
Increased ability to cope. patient to notify health care professional if
Decreased delirium and tremors when used for alcohol pregnancy is planned or suspected, or if
withdrawal breast feeding.
ACTIVE LEARNING TEMPLATES
