CPHON Study Guide Questions and Answers

CPHON Study Guide Questions and Answers What does Hydroxyurea stimulate? fetal hgb What is Rituximab? Monoclonal antibody acts against CD20 used for Burkitts Lymphoma Where is erythropoietin produced? kidneys epryhropoietin: regulates and controls the production of maturation of RBCs What is Septra and Dapsone for? to prevent pneumocystis jiroveci. What can Septra (Bactrim) cause? bone marrow suppression Imatinib is best treatment for.... CML What can Tacrolimus cause? reversible posterior encephalopathy Dactinomycin can cause? radiation recall Bleomycin can cause? pulmonary fibrosis. Make sure to tell anesthesia before being put to sleep. You cannot hyper oxygenate bc it will make it worse. What chemos have a max dose? Bleomycin Doxorubicin 550mg/m2 What can Asparaginase cause? Pancreatitis and High blood sugar What can VP16 cause? secondary AML Alkylating agents are responsible for... fertility issues. Think of transplant chemos and high dose chemos like cisplatin, ifosphamide What is the first line of treatment for hemolytic anemia? Steroids What drug is given for iron overload? Deferoxamine it is a chelating agent Most common childhood cancer? ALL Most common solid tumor cancer? Brain tumors Astrocytoma: most common brain tumor Medulloblastoma: most common malignant brain tumor Most common extracranial solid tumor? NB Alkylating Agents.... interrupts the cell cycle cytoxan (cycle) Ifosfamide Lomustine Carmustine Buslfan Procarbazine Temozolimide Decarbazine Cisplatin Carboplatin Antitumor Antiboitics.... interfere with cell metabolism Dactinomycin Bleomycin Daunorubicin Doxorubicin Idarubicin Antimetabolites.... Stops the ability at the nucleus 5FU 6MP Gemcitabine Fludarabine Cytrarbine Hydroxyurea Methotrexate Plant Alkaloids.... cause DNA breakdown VP16 Paclitaxel Docetaxel Topotecan Irinotecan Vincristine:max single dose 2mg Vinblastine Vinorelbine Miscellaneous... mechanisms not understood Asparaginase Retinoids Imatinib (Gleevac) Ambisome antifungal check K think about pt on antibiotics for 1 week and still having F/N think fungal What are Biologic Response Modifiers (BRM)? attack targeted pathways and tumor receptor sites What scan is gold standard with NB? MIBG What is Flagyl used for? Cdiff Tacrolimus side effects? Hypomagnesium Hearling loss Dizzy What does Mag sulfate prevent with Cisplatin? leg cramps Labs associated with DIC Increased: PT, PTT, D-Dimer Decreased: Platlets, Fibrinogen What antibiotic do you use for a line infection? PCN Pt is 10 days post transplant with pulmonary edema...what was the cause? Capillary leak syndrome from chemo What is myeloablation therapy? completely wiping out the system preps against GVHD ATG prepares the bone marrow for transplant by destroying the patients circulating T lymphocytes What are B and T lymphocytes deficit in? antibodies Best treatment if necrotic tissue around a tumor? surgery Clinical Trials 1. Max tolerated dose 2. tx on specific disease. Must have measurable diagnosis 3. new tx vs standard tx Why limit platelet transfusions? to prevent alloimmunization also think single platelet donor 1st signs of Wilms asymptomatic abdominal mass hematuria Tumor Lysis Syndrom (TLS) affects kidneys 1st treatment for mediastinal mass? Radiation Baby with rash and skin nodules...what do you think of?? Langerhans Histocytosis (LAD) What do platelets need to be greater than for surgery? 50 Calculate an ANC (Bands + Segs) x WBC x 10 What is Kostmann's syndrome? chronic neutropenia deficient in Neutrophils (lymphocytes) 18 month old can't pick up blocks...what chemo do you think of? Vincristine-peripheral neuropathy Pt with severe pain related to mucositis with pain meds every 4 hours. What would nurse expect next? Cont. narcotic infusion Hospice patient with cont. Morphine and what to change to send home. What would you expect? Fentanyl patch Hyperdiploidy is favorable in.... ALL Think extra chromosomes is better! Ethics committee purpose? "compromise" Carmustine causes... pulmonary fibrosis alkylating agent What pt would have radiation initially? 5 y/o with Medulloblastoma Brother and Sister twins come in with nose bleeds...what do they have? Von Willebrands Adopted Chinese girl with a hbg of 5....diagnosis? Beta Thal What should we focus on with a dying patient? family needs What should you do with a WBC of 250,000? Hyperhydrate Thinking hyperleukocytosis (WBC greater than 100,000) Family is worried about financial burden of new diagnosis, what does nurse give info about? COBRA What is Ganciclovir used for? Treat CML (Cytomeaglovirus) New family with suspected malignancy....what question would the nurse ask? Why are you here today? Need to find out what they know 1st to see if they understand If pt is allergic to Septra what would you give? Dapsone