Chemotherapy Biotherapy Certification Exam
Study Guide Questions and Answers 100% Pass
Resources - ✔✔nccn.org
cancer.org
LESSON 1: Cell cycle - ✔✔g1- increase in size
s- dna replicated
g2- cell enlarge and ready to divide
m phase- 2 hours
mitosis - ✔✔4 stages, prophase, metaphase, anaphase, telophase
-chemo targets certain points in the process
apoptosis - ✔✔programmed cell death
hematopoiesis - ✔✔formation of blood cells & how cells differentiate
-myeloid: pre cells mature into RBCs, platelets and WBCs
-lymphoid: pre cells- mature into WBCS
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,Principles of Biotherapy: p51-95 immunology - ✔✔-defense against foreign
organisms, homeostasis (destroy aged cells), surveillance
immune responses - ✔✔innate: primary line of defense, non specific, no
memory
adaptive: secondary line of defence with specific memry
cytokines - ✔✔-effect growth and differentiation of WBC
-interferons, tumor necrosis factors, growth factos and interleukins
-small protein molecules released by cells throughout body providing
comunication between cells of the immune system
-regular antiboddy production and function of b cells
vaccines for cancer prevention - ✔✔-hep B prevents hepatitis and
hepatocellular carcinoma
-hpv vaccine
filgrastim aka neupogen - ✔✔SC or IV to derease infection in patients with
neutropenic fever associated with myelosuppressive anticancer treatments
for nonmyeloid malignancies
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,tbo-filgramstim/ pegfilgrastim - ✔✔reduce duration of neutroenia in
patients with non myeloid malignancies
palifermin - ✔✔IV to dec incidence of oral mucositis in patients with hem
malignanies before BMT
sargramostim - ✔✔aka leukine - patients with AML following chemo to
shorten neutrophil recovery and reduce incidence of infection
IFN gamma - ✔✔reduce frequency and severity o infections related to
granulomatous disease
aldeleukin - ✔✔treat renal cell carcinoma and metastatic melanoma
oprevelkin - ✔✔prevent severe thrombocytopenia and refuce need for
platelet transfusions in patients with nonmyeloid malig
plerixafor - ✔✔with filgrastim to mobilize hematopoeitc stem cells for
collection from peripheral blood of patients
sipuleucel - ✔✔castrate resistant prostate cancer
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, rituximab - ✔✔rituxan- treatment of relapsed or refractory low grade
follicular b cell NHL_ first line traetment in combo with chemo in patients
with response
-can treat severe rheumatoid arthritis
-can have severe reactions (hypotension, urticaria, angiodema, hypoxia,
rigors, dyspnea, chills, fever, nausea, rash, renal tox)
-premed with tylenol and benadryl
-slow infusion to resolve some side effects, side effects reduce with each
infusion
immune system - ✔✔1st line: skin , ucous membrane, gut flora
second line: phagocytes:
3rd line antibodies, t and b cells
malignant tumor (cancer) - ✔✔cell strcuture different from parent tissue,
cell division uncontrolled, loosely adherent, invade neighboring tissue,
establish blood vessels
Approaches to treatment - ✔✔cure: prolonged absence of disease
Copyright ©EMILLECT 2024. ALL RIGHTS RESERVED. Page 4/35
Study Guide Questions and Answers 100% Pass
Resources - ✔✔nccn.org
cancer.org
LESSON 1: Cell cycle - ✔✔g1- increase in size
s- dna replicated
g2- cell enlarge and ready to divide
m phase- 2 hours
mitosis - ✔✔4 stages, prophase, metaphase, anaphase, telophase
-chemo targets certain points in the process
apoptosis - ✔✔programmed cell death
hematopoiesis - ✔✔formation of blood cells & how cells differentiate
-myeloid: pre cells mature into RBCs, platelets and WBCs
-lymphoid: pre cells- mature into WBCS
Copyright ©EMILLECT 2024. ALL RIGHTS RESERVED. Page 1/35
,Principles of Biotherapy: p51-95 immunology - ✔✔-defense against foreign
organisms, homeostasis (destroy aged cells), surveillance
immune responses - ✔✔innate: primary line of defense, non specific, no
memory
adaptive: secondary line of defence with specific memry
cytokines - ✔✔-effect growth and differentiation of WBC
-interferons, tumor necrosis factors, growth factos and interleukins
-small protein molecules released by cells throughout body providing
comunication between cells of the immune system
-regular antiboddy production and function of b cells
vaccines for cancer prevention - ✔✔-hep B prevents hepatitis and
hepatocellular carcinoma
-hpv vaccine
filgrastim aka neupogen - ✔✔SC or IV to derease infection in patients with
neutropenic fever associated with myelosuppressive anticancer treatments
for nonmyeloid malignancies
Copyright ©EMILLECT 2024. ALL RIGHTS RESERVED. Page 2/35
,tbo-filgramstim/ pegfilgrastim - ✔✔reduce duration of neutroenia in
patients with non myeloid malignancies
palifermin - ✔✔IV to dec incidence of oral mucositis in patients with hem
malignanies before BMT
sargramostim - ✔✔aka leukine - patients with AML following chemo to
shorten neutrophil recovery and reduce incidence of infection
IFN gamma - ✔✔reduce frequency and severity o infections related to
granulomatous disease
aldeleukin - ✔✔treat renal cell carcinoma and metastatic melanoma
oprevelkin - ✔✔prevent severe thrombocytopenia and refuce need for
platelet transfusions in patients with nonmyeloid malig
plerixafor - ✔✔with filgrastim to mobilize hematopoeitc stem cells for
collection from peripheral blood of patients
sipuleucel - ✔✔castrate resistant prostate cancer
Copyright ©EMILLECT 2024. ALL RIGHTS RESERVED. Page 3/35
, rituximab - ✔✔rituxan- treatment of relapsed or refractory low grade
follicular b cell NHL_ first line traetment in combo with chemo in patients
with response
-can treat severe rheumatoid arthritis
-can have severe reactions (hypotension, urticaria, angiodema, hypoxia,
rigors, dyspnea, chills, fever, nausea, rash, renal tox)
-premed with tylenol and benadryl
-slow infusion to resolve some side effects, side effects reduce with each
infusion
immune system - ✔✔1st line: skin , ucous membrane, gut flora
second line: phagocytes:
3rd line antibodies, t and b cells
malignant tumor (cancer) - ✔✔cell strcuture different from parent tissue,
cell division uncontrolled, loosely adherent, invade neighboring tissue,
establish blood vessels
Approaches to treatment - ✔✔cure: prolonged absence of disease
Copyright ©EMILLECT 2024. ALL RIGHTS RESERVED. Page 4/35
