Inhoud
Hoorcollege 1: History of Neuropsychology (02-09) ............................................................................... 7
Leerdoelen ....................................................................................................................................... 7
Studiemateriaal ............................................................................................................................... 7
History ................................................................................................................................................. 7
Antiquity (400 BCE – 300 BCE)......................................................................................................... 8
Renaissance (1500 – 1900) .............................................................................................................. 8
19th century (1800 – WWI) .............................................................................................................. 9
20th century (1900 – 1990) .............................................................................................................. 9
Dark history ................................................................................................................................... 10
Hoorcollege 2: DSM en diermodellen (03-09) ....................................................................................... 11
Leerdoelen:........................................................................................................................................ 11
Definities........................................................................................................................................ 11
Classificatie psychiatrische stoornissen ............................................................................................. 11
DSM ............................................................................................................................................... 11
Alternatieven ................................................................................................................................. 14
Onderzoek naar hersenziektes op verschillende niveaus.............................................................. 15
Diermodellen ..................................................................................................................................... 17
Gebruik van diermodellen in onderzoek ....................................................................................... 17
Diermodel: goed model voor mens? (Artikel) ............................................................................... 17
Beperkingen diermodellen ............................................................................................................ 19
Soorten diermodellen.................................................................................................................... 19
Hoorcollege 3: Dementie (05-09) .......................................................................................................... 22
De ziekte van Alzheimer en dementie ............................................................................................... 22
Leerdoelen ..................................................................................................................................... 22
Verschijnselen / symptomen; ........................................................................................................ 22
Progressie ...................................................................................................................................... 23
Prevalentie en soorten .................................................................................................................. 23
Veranderingen in de hersenen ...................................................................................................... 23
Overige veranderingen .................................................................................................................. 25
Genetische (risico)factoren bij AD ................................................................................................. 29
Overige risicofactoren ................................................................................................................... 31
Genetica......................................................................................................................................... 31
Therapie ......................................................................................................................................... 32
Part I: Frontotemporal Dementia (FDT) ............................................................................................. 35
, Leerdoelen ..................................................................................................................................... 35
Materiaal ....................................................................................................................................... 35
FDT and variants ............................................................................................................................ 35
Diagnosis........................................................................................................................................ 36
Brain differences ............................................................................................................................ 37
Progression .................................................................................................................................... 38
Genetics ......................................................................................................................................... 38
Neuropathology............................................................................................................................. 38
Misdiagnosis and treatment .......................................................................................................... 39
Summary ....................................................................................................................................... 39
Part II: Dementia with Lewy Bodies................................................................................................... 39
Learning outcomes ........................................................................................................................ 39
Learning materials ......................................................................................................................... 40
Dementia with Lewy Bodies .......................................................................................................... 40
Prevalence ..................................................................................................................................... 40
Neuropathology............................................................................................................................. 40
Genetics ......................................................................................................................................... 40
Clinical Characteristics ................................................................................................................... 40
Treatment ...................................................................................................................................... 41
Summary ....................................................................................................................................... 41
Guess the disorder exercise (slide 44): .......................................................................................... 42
Hoorcollege 4: Eetstoornissen (06-09) .................................................................................................. 43
Anorexia Nervosa (AN) ...................................................................................................................... 43
Leerdoelen ..................................................................................................................................... 43
Introductie ..................................................................................................................................... 43
Behandeling van AN ...................................................................................................................... 44
Psychofarmacologie ....................................................................................................................... 45
Neuropathofysiologie .................................................................................................................... 46
Obesitas ............................................................................................................................................. 48
Leerdoelen ..................................................................................................................................... 48
Epidemie ........................................................................................................................................ 48
Neurobiologie ................................................................................................................................ 49
Behandeling ................................................................................................................................... 53
Hoorcollege 5: Traumatisch hersenletsel (09-09) .................................................................................. 57
Learning objectives ........................................................................................................................ 57
Reading material............................................................................................................................ 57
, Overview............................................................................................................................................ 57
Definition and classification .......................................................................................................... 57
Epidemiology ................................................................................................................................. 57
Risk factors and causes .................................................................................................................. 57
Long-term implications.................................................................................................................. 58
Classification .................................................................................................................................. 58
Neuropathology............................................................................................................................. 59
Penetrating head injuries (PHI).......................................................................................................... 60
Causes ............................................................................................................................................ 60
Mortality & Severity ...................................................................................................................... 60
Types of injuries ............................................................................................................................. 60
Neuropathology............................................................................................................................. 60
Outcome ........................................................................................................................................ 60
Progression .................................................................................................................................... 61
Closed head injuries (CHI) ................................................................................................................. 61
Definition ....................................................................................................................................... 61
Mild TBI.......................................................................................................................................... 63
Moderate TBI ................................................................................................................................. 64
Severe TBI ...................................................................................................................................... 65
Moderator variables .......................................................................................................................... 66
Age ................................................................................................................................................. 66
Repeated TBIs ................................................................................................................................ 66
Chronic Traumatic Encephalopathy (CTE)...................................................................................... 66
Polytrauma .................................................................................................................................... 66
Alcohol and substance use ............................................................................................................ 66
Summary ........................................................................................................................................... 67
Hoorcollege 6: Genetische ontwikkelingsstoornissen (10-11) .............................................................. 68
Learning outcomes ............................................................................................................................ 68
Learning materials ............................................................................................................................. 68
Overview of genetic mechanisms...................................................................................................... 68
Types of mutations ........................................................................................................................ 68
Neuroconstructivism ..................................................................................................................... 69
Genotype to Phenotype ................................................................................................................ 69
Disorders of known genetic disorders ........................................................................................... 69
Down Syndrome ................................................................................................................................ 69
Genetics ......................................................................................................................................... 70
, Physical characteristics .................................................................................................................. 70
Health concerns ............................................................................................................................. 70
Risk factors..................................................................................................................................... 70
Cognitive phenotype ..................................................................................................................... 71
Language........................................................................................................................................ 71
Gene x Environment ...................................................................................................................... 71
Neural phenotype.......................................................................................................................... 72
Summary Down Syndrome ............................................................................................................ 72
William’s Syndrome ........................................................................................................................... 72
Genetics ......................................................................................................................................... 73
Health concerns ............................................................................................................................. 73
Physical characteristics .................................................................................................................. 73
Visuospatial cognition ................................................................................................................... 73
Language........................................................................................................................................ 73
Hypersociability ............................................................................................................................. 74
Neural phenotype.......................................................................................................................... 74
Environment .................................................................................................................................. 74
Summary Williams Syndrome ....................................................................................................... 75
Fragile-X Syndrome............................................................................................................................ 75
Genetics ......................................................................................................................................... 75
Psychical characteristics ................................................................................................................ 76
Health concerns ............................................................................................................................. 76
Inherited ........................................................................................................................................ 76
Cognitive phenotype ..................................................................................................................... 76
Neural phenotype.......................................................................................................................... 77
Environment .................................................................................................................................. 77
Summary Fragile-X Syndrom ......................................................................................................... 78
Comparison ....................................................................................................................................... 78
Hoorcollege 7: Genderdysforie (12-09) ................................................................................................. 79
Sekse en gender ................................................................................................................................ 79
Leerdoelen ..................................................................................................................................... 79
Sekse versus gender ...................................................................................................................... 79
Sekse en gender in klinische psychologie ...................................................................................... 80
Sekse en gender in onderzoek....................................................................................................... 82
Genderdysforie .................................................................................................................................. 85
Leerdoelen ..................................................................................................................................... 85
Hoorcollege 1: History of Neuropsychology (02-09) ............................................................................... 7
Leerdoelen ....................................................................................................................................... 7
Studiemateriaal ............................................................................................................................... 7
History ................................................................................................................................................. 7
Antiquity (400 BCE – 300 BCE)......................................................................................................... 8
Renaissance (1500 – 1900) .............................................................................................................. 8
19th century (1800 – WWI) .............................................................................................................. 9
20th century (1900 – 1990) .............................................................................................................. 9
Dark history ................................................................................................................................... 10
Hoorcollege 2: DSM en diermodellen (03-09) ....................................................................................... 11
Leerdoelen:........................................................................................................................................ 11
Definities........................................................................................................................................ 11
Classificatie psychiatrische stoornissen ............................................................................................. 11
DSM ............................................................................................................................................... 11
Alternatieven ................................................................................................................................. 14
Onderzoek naar hersenziektes op verschillende niveaus.............................................................. 15
Diermodellen ..................................................................................................................................... 17
Gebruik van diermodellen in onderzoek ....................................................................................... 17
Diermodel: goed model voor mens? (Artikel) ............................................................................... 17
Beperkingen diermodellen ............................................................................................................ 19
Soorten diermodellen.................................................................................................................... 19
Hoorcollege 3: Dementie (05-09) .......................................................................................................... 22
De ziekte van Alzheimer en dementie ............................................................................................... 22
Leerdoelen ..................................................................................................................................... 22
Verschijnselen / symptomen; ........................................................................................................ 22
Progressie ...................................................................................................................................... 23
Prevalentie en soorten .................................................................................................................. 23
Veranderingen in de hersenen ...................................................................................................... 23
Overige veranderingen .................................................................................................................. 25
Genetische (risico)factoren bij AD ................................................................................................. 29
Overige risicofactoren ................................................................................................................... 31
Genetica......................................................................................................................................... 31
Therapie ......................................................................................................................................... 32
Part I: Frontotemporal Dementia (FDT) ............................................................................................. 35
, Leerdoelen ..................................................................................................................................... 35
Materiaal ....................................................................................................................................... 35
FDT and variants ............................................................................................................................ 35
Diagnosis........................................................................................................................................ 36
Brain differences ............................................................................................................................ 37
Progression .................................................................................................................................... 38
Genetics ......................................................................................................................................... 38
Neuropathology............................................................................................................................. 38
Misdiagnosis and treatment .......................................................................................................... 39
Summary ....................................................................................................................................... 39
Part II: Dementia with Lewy Bodies................................................................................................... 39
Learning outcomes ........................................................................................................................ 39
Learning materials ......................................................................................................................... 40
Dementia with Lewy Bodies .......................................................................................................... 40
Prevalence ..................................................................................................................................... 40
Neuropathology............................................................................................................................. 40
Genetics ......................................................................................................................................... 40
Clinical Characteristics ................................................................................................................... 40
Treatment ...................................................................................................................................... 41
Summary ....................................................................................................................................... 41
Guess the disorder exercise (slide 44): .......................................................................................... 42
Hoorcollege 4: Eetstoornissen (06-09) .................................................................................................. 43
Anorexia Nervosa (AN) ...................................................................................................................... 43
Leerdoelen ..................................................................................................................................... 43
Introductie ..................................................................................................................................... 43
Behandeling van AN ...................................................................................................................... 44
Psychofarmacologie ....................................................................................................................... 45
Neuropathofysiologie .................................................................................................................... 46
Obesitas ............................................................................................................................................. 48
Leerdoelen ..................................................................................................................................... 48
Epidemie ........................................................................................................................................ 48
Neurobiologie ................................................................................................................................ 49
Behandeling ................................................................................................................................... 53
Hoorcollege 5: Traumatisch hersenletsel (09-09) .................................................................................. 57
Learning objectives ........................................................................................................................ 57
Reading material............................................................................................................................ 57
, Overview............................................................................................................................................ 57
Definition and classification .......................................................................................................... 57
Epidemiology ................................................................................................................................. 57
Risk factors and causes .................................................................................................................. 57
Long-term implications.................................................................................................................. 58
Classification .................................................................................................................................. 58
Neuropathology............................................................................................................................. 59
Penetrating head injuries (PHI).......................................................................................................... 60
Causes ............................................................................................................................................ 60
Mortality & Severity ...................................................................................................................... 60
Types of injuries ............................................................................................................................. 60
Neuropathology............................................................................................................................. 60
Outcome ........................................................................................................................................ 60
Progression .................................................................................................................................... 61
Closed head injuries (CHI) ................................................................................................................. 61
Definition ....................................................................................................................................... 61
Mild TBI.......................................................................................................................................... 63
Moderate TBI ................................................................................................................................. 64
Severe TBI ...................................................................................................................................... 65
Moderator variables .......................................................................................................................... 66
Age ................................................................................................................................................. 66
Repeated TBIs ................................................................................................................................ 66
Chronic Traumatic Encephalopathy (CTE)...................................................................................... 66
Polytrauma .................................................................................................................................... 66
Alcohol and substance use ............................................................................................................ 66
Summary ........................................................................................................................................... 67
Hoorcollege 6: Genetische ontwikkelingsstoornissen (10-11) .............................................................. 68
Learning outcomes ............................................................................................................................ 68
Learning materials ............................................................................................................................. 68
Overview of genetic mechanisms...................................................................................................... 68
Types of mutations ........................................................................................................................ 68
Neuroconstructivism ..................................................................................................................... 69
Genotype to Phenotype ................................................................................................................ 69
Disorders of known genetic disorders ........................................................................................... 69
Down Syndrome ................................................................................................................................ 69
Genetics ......................................................................................................................................... 70
, Physical characteristics .................................................................................................................. 70
Health concerns ............................................................................................................................. 70
Risk factors..................................................................................................................................... 70
Cognitive phenotype ..................................................................................................................... 71
Language........................................................................................................................................ 71
Gene x Environment ...................................................................................................................... 71
Neural phenotype.......................................................................................................................... 72
Summary Down Syndrome ............................................................................................................ 72
William’s Syndrome ........................................................................................................................... 72
Genetics ......................................................................................................................................... 73
Health concerns ............................................................................................................................. 73
Physical characteristics .................................................................................................................. 73
Visuospatial cognition ................................................................................................................... 73
Language........................................................................................................................................ 73
Hypersociability ............................................................................................................................. 74
Neural phenotype.......................................................................................................................... 74
Environment .................................................................................................................................. 74
Summary Williams Syndrome ....................................................................................................... 75
Fragile-X Syndrome............................................................................................................................ 75
Genetics ......................................................................................................................................... 75
Psychical characteristics ................................................................................................................ 76
Health concerns ............................................................................................................................. 76
Inherited ........................................................................................................................................ 76
Cognitive phenotype ..................................................................................................................... 76
Neural phenotype.......................................................................................................................... 77
Environment .................................................................................................................................. 77
Summary Fragile-X Syndrom ......................................................................................................... 78
Comparison ....................................................................................................................................... 78
Hoorcollege 7: Genderdysforie (12-09) ................................................................................................. 79
Sekse en gender ................................................................................................................................ 79
Leerdoelen ..................................................................................................................................... 79
Sekse versus gender ...................................................................................................................... 79
Sekse en gender in klinische psychologie ...................................................................................... 80
Sekse en gender in onderzoek....................................................................................................... 82
Genderdysforie .................................................................................................................................. 85
Leerdoelen ..................................................................................................................................... 85
