VARYING RENAL FUNCTION ON DRUG DOSING AND CREATININE

VARYING RENAL FUNCTION ON DRUG DOSING AND CREATININE Part 1 Q1a). What Are the Implications of Varying Renal Function on Drug Dosing and Creatinine Changing renal function has implications on drug dosing. It may decrease the effectiveness of drugs, making them lose efficacy or increase drug effects. Most of the time, it increases their effects. Therefore, potential toxicity and pharmacokinetics change. On the other hand, altering renal function affects creatinine production as well as creatinine clearance. b). Identify Effects of the Following on Drugs Stages and Dosing 1. Cirrhosis Cirrhosis has a significant effect on drug pharmacokinetics, drug clearance, and pharmacodynamics (Weersink, Bouma, Burger, Drenth, Hunfeld, Kranenborg & Borgsteede, 2016). For instance, the cirrhotic patient frequently undergoes avertible adverse drug effects such as drug reactions. Cirrhosis often causes alterations, which in turn causes common drug dosage to have more significant toxic effects. However, there are no regulations to modify the drug dosage in cirrhotic patients. b). Protein Binding