ASCP Hematology Exam Questions and Answers / MLT Latest Update .

ASCP Hematology Exam Questions and Answers / MLT Latest Update . The light-colored zone adjacent to the nucleus in a plasmacyte is the: A. ribosome B. chromatin C. mitochondria D. Golgi area - ANSWER D. Golgi area The majority of the iron in an adult is found as a constituent of: A. hemoglobin B. hemosiderin C. myoglobin D. transferrin - ANSWER A. hemoglobin The main function of the hexose monophosphate shunt in the erythrocyte is to: A. reglate the level of 2,3-DPG B. provide reduced glutathione to prevent oxidation of hemoglobin C. prevent the reduction of heme iron D. provide energy for membrane maintenance - ANSWER B. provide the level 2,3-DPG In order for hemoglobin to combine reversibly with oxygen, the iron must be: A. complexed with haptoglobin B. freely circulating in the cytoplasm C. attached to transferrin D. in the ferrous state - ANSWER D. in the ferrous state In which of the following disease states are teardrop cells and adnormal platelets most characteristically seen? ASCP Hematology Exam Questions and Answers / MLT Latest Update A. hemolytic anemia B. multiple myeloma C. G-6-PD deficiency D. myeloid metaplasma - ANSWER D. myeloid metaplasia In the normal adult, the spleen acts as a site for: A. storage of red blood cells B. production of red blood cells C. synthesis of erythropoietin D. removal of imperfect and aging cells - ANSWER D. removal of imperfect and aging cells After removal of red blood cells from the circulation hemoglobin is broken down into: A. iron, porphyrin, and amino acids B. iron, protoporphyrin, and globin C. heme, protoporphyrin, and amino acids D. heme, hemoseridin, and globin - ANSWER B. iron, protoporphyrin, and globin Heinz bodies are: A. readily identified with polychrome stains B. rarely found in glucose-6-phosphate dehydrogenase deficient erythrocytes C. closely associated with spherocytes D. denatured hemoglobin inclusions that are readily removed by the spleen - ANSWER D. denatured hemoglobin inclusions that are readily removed by the spleen Cells for the transport of O2 and CO2 are: A. erythrocytes B. granulocytes C. lymphocytes D. thrombocytes - ANSWER A. erythrocytes Erythropoeitin acts to: A. shorten the replication time of the granulocytes B. stimulate RNA synthesis of erythroid cells C. increase colony-stimulating factors produced by the B-lymphocytes D. decrease the release of marrow reticulocytes - ANSWER B. stimulate RNA synthesis of erythroid cells What cell shape is most commonly associated with an increase MCHC? A. teardrop cells B. target cells C. spherocytes D. sickle cells - ANSWER C. spherocytes Which of the following characteristics are common to hereditary spherocytosis, hereditary elliptocytosis, hereditary stomatocytosis, and paroxysmal nocturnal hemoglobinuria? A. autosomal dominant inheritance B. red cell membrane defects C. positive direct anti-globulin test D. measured platelet count - ANSWER B. red cell membrane defects Which of the following is most closely associated with iron deficiency anemia? A. iron overload in tissue B. target cells C. basophilic stippling D. chronic blood loss - ANSWER D. chronic blood loss Evidence indicates that the generic defect in thalassemia usually results in? A. the production of abnormal globin class B. a quantitative deficiency in RNA resulting in decreased globin chain production C. a structured change in the heme portion of the hemoglobin D. an abnormality in the alpha- or beta-chain binding or affinity - ANSWER B. a quantitative deficiency in RNA resulting in decreased globin chain production An enzyme deficiency assciated with moderate to sever hemolytic anemia after the patient is exposed to certain drugs and characteristized by red cell inclusions formed by denatured hemoglobin is: A. lactate dehydrogenase deficiency B. G-6-PD deficiency C. pyruvate kinase deficiency D. hexokinase deficiency - ANSWER B. G-6-PD deficiency Patients with A(-) type G-6-PD deficiency are least likely to have hemolytic episodes in which of the following situations? A. following administration of oxidizing drugs B. following ingestion of fava beans C. during infections D. spontaneously - ANSWER D. spontaneously A patient has a congenital nonspherocytic hemolytic anemia. After exposure to anti-malarial drugs, the patient experiences a severe hemolytic episode. This episode is characterized by red cell inclusions caused by hemoglobin denaturation. Which of the following conditions is most consistent with these findings? A. G-6-PD deficiency B. thalassemia major C. pyruvate kinase deficiency D. paroxysmal nocturnal hemoglobinuria - ANSWER A. G-6-PD deficiency Peripheral blood smears from patients with untreated pernicious anemia are characterized by: A. pancytopenia and macrocytosis B. leukocytosis and elliptocytosis C. leukocytosis and ovalocytosis D. pancytopenia and microcytosis - ANSWER A. pancytopenia and macrocytosis Laboratory tests performed on a patient indicate macrocytosis, anemia, leukopenia, and thrombocytopenia. Which of the following disorders is the patient most likely to have? A. anemia of chronic disorder B. vitamin B12 deficiency C. iron deficiency D. acute hemorrhage - ANSWER B. vitamin B12 deficiency The characteristic morphological feature in folic acid deficiency is: A. macrocytosis B. target cells C. basophilic stippling D. rouleax formation - ANSWER A. macrocytosis The most likely cause of the macrocytosis that often accompanies anemia of myelofibrosis is: A. folic acid deficiency B. increased reticulocyte count C. inadequate B12 absorption D. pyroxine deficiency - ANSWER A. folic acid deficiency A characteristic morphologic feature in hemoglobin C disease is: A. macrocytosis B. spherocytosis