IBCLC Exam: Research, Medications and Breast Milk Questions And Answers A+

IBCLC Exam: Research, Medications and Breast Milk Questions And Answers A+ maternal plasma concentration - ANS-main driver of milk concentration of drug as level in blood falls, drug diffuses out of milk back into blood molecular weight of drug - ANS-drug over 800 Daltons doesn't pass into milk easily ex. insulin is 6000 Da heparin is 40,000 Da alcohol 200 Da caffeine 194 Da protein binding of drugs - ANS-most drugs pass into milk while bound to albumin some drugs are highly (>90%) protein bound to other proteins and don't easily pass into milk ex. ibuprofen, warfarin, diazepam, propanolol but lithium is 0% and passes into milk lipid solubility of drugs - ANS-higher lipid solubility means more drug in milk CNS drugs tend to have higher lipid solubility - antidepressants, anti-anxiety medication in colostrum - CONTINUES...