WEEK 1 Walden 6501 advanced pathophysiology (genetics, cellular biology and tissue) Exam 2024

WEEK 1 Walden 6501 advanced pathophysiology (genetics, cellular biology and tissue) Exam 2024 acrocentric -Answer-refers to the terminal location of centromere on chromosomes 13, 14, 15, 21, and 22 allelic heterogeneity -Answer-the situation in which multiple alleles at a single locus can produce one or more disease phenotypes. amorphic -Answer-refers ro mutations that cause a complete loss of function for the respective gene, and therefore yield the same phenotype as a complete gene deletion. aneuploidy -Answer-a general term used to denote any unbalanced chromosome complement antimorphic -Answer-refers to mutations that when present in heterozygous form opposite a nonmutant allele will result in a phenotype similar to homozygous for loss of function alleles. ascertainment bias -Answer-the situation in which individuals or families in a genetic study are not representative of the general population because of the way in which they are identified autosomal -Answer-located on chromosomes 1-22 rather than x or y CpG island -Answer-a segment of DNA that contains a relatively high density of 5' - CG-3' dinucleotides. Such segments are frequently unmethylated and located close to ubiquitously expressed genes