ASCP Hematology Exam Questions And Answers

ASCP Hematology Exam Questions And Answers Dohle bodies - ANS Light blue patches in cytoplasm of neutrophils. Infection, burns Erythrocytes - ANS O2 transport. Produced in BM Mean Corpuscular Hemoglobin (MCH) formula - ANS (HGBx10)/RBC Mean Corpuscular Hemoglobin Concentration (MCHC) formula - ANS (HGBx100)/HCT Granulocytes - ANS Defense against bacterial infection. Produced in BM Lymphocytes - ANS Cellular and humoral immunity. Produced in lymphoid tissue Platelets - ANS Coagulation. Produced in BM WBC RR - ANS 4.5-11.5 x10^3 / microL RBC RR - ANS M: 4.6-6x10^6 / microL F: 4-5.4x10^ / microL HGB RR - ANS M: 14-18 g/dL F: 12-15 g/dL HCT RR - ANS M: 40-54% F: 35-49% MCV RR - ANS 80-100 fL MCH RR - ANS 27-31 pg MCHC RR - ANS 32-36% PLT RR - ANS 150-450x10^3 microL MCV first 5 days - ANS Macrocytes. Higher in preterm infants Retic % - ANS newborns increased polychromasia Seg % - ANS 50-70 Band % - ANS 0-5 Lymph newborn - ANS few benign immature B cells may be seen common myeloid progenitor - ANS differentiate into erythrocytes, platelets (megaK), granulocytes (basophils, eosinophil, neutrophil), and monocytes common lymphoid progenitor (CLP) - ANS T-lymph, NK cell, B-lymph Multipotent progenitor cell - ANS Common myeloid progenitor or common lymphoid progenitor Erythropoiesis 1-2 month gestation - ANS yolk sac and aorta-gonads mesonephros region (gower I/II and portland) Erythropoiesis 3-6 month gestation - ANS liver (primary), spleen Erythropoiesis 7 month of gestation-4 years - ANS Bone marrow (all marrow active) Erythropoiesis adult - ANS bone marrow (pelvis, vertebrae, ribs, sternum, skull. Shafts of long bones filled with fat-may reactivate to compensate for anemia- liver and spleen may reactivate if that fails to keep up with demand) Rubriblast/pronormoblast - ANS 14-24 um N:C ratio 8:1 Royal blue cytoplasm. Fine chromatin 1-2 nucleoli Normally confined to bone marrow. Prorubricyte/basophilic normoblast - ANS 12-17 um N:C ratio 6:1 Chromatin is coarser with slightly visible parachromatin Nucleoli not visible Normally confined to bone marrow. Rubricyte/polychromatophilic normoblast - ANS 10-15 um. N:C ratio 4:1. Cytoplasm is polychromatophilic due to hemoglobin production. Chromatin is clumped with distinct areas of parachromatin. Last stage to divide. Normally confined to bone marrow. Metarubricyte/orthochromic normoblast - ANS 8-12 um N:C ratio 1:2 Nucleus is pyknotic Last nucleated stage Normally confined to bone marrow.