BMTCN - Chapter 5 (chronic GVHD) 2023/2024 already passed

BMTCN - Chapter 5 (chronic GVHD) What is chronic GVHD? - correct answer Late complication of HSCT effecting quality of life, immune mediated disorder. Must have at least one diagnostic manifestation of chronic GVHD or at least one distinctive sign confirmed by lab test. It can involve one or more organs. Failure to improve after at least 2 months or progression after 1 month of standard corticosteroid based immunosuppressive therapy What differs between chronic and acute GVHD? - correct answer Clinical symptoms, NOT time of onset What is the goal of chronic GVHD treatment? - correct answer Balance between controlling symptoms with least amount of steroids and immunosuppressants What are the two types of chronic GVHD? - correct answer Class chronic: without any features of acute GVHD Overlap syndrome: features of both acute and chronic manifestations occur What are the risk factors of developing chronic GVHD? - correct answer -Prior acute GVHD -Increasing severity of acute GVHD -HLA mismatched unrelated donors -Increased age of donor/recipient -Type of pretransplant GVHD prophylaxis -use of non T cell depleted graft -Source of stem cells (mobilized PBSCs have higher risk over bone marrow) -Donor sex mismatched -Bone marrow T cell depleted grafts have lowest incidence -Splenectomy -Donor leukocyte infusions What are the manifestations of skin chronic GVHD? - correct answer -Tight or hard skin -Increased dryness -New rash -Papules -Discoloration -Scaly What are the manifestations of mouth chronic GVHD? - correct answer -Oral dryness -taste alterations -sensitivities -ulcers/pain What are the manifestations of eye chronic GVHD? - correct answer -dry/painful eyes -photophobia What are the manifestations of genital chronic GVHD? - correct answer -Erosions, ulcers -Vag dryness/burning What are the manifestations of GI chronic GVHD? - correct answer -Concentric rings in esophagus -N/V/D, FTT -Wasting syndrome What are the manifestations of lung chronic GVHD? - correct answer -Cough -Dyspnea -Wheezes