BMTCN NUMBERS TO KNOW

FOUNDATIONS OF TRANSPLANT EXAM
QUESTIONS AND ANSWERS
CXCR4 - answer Regulates trafficking and homing of stem cells


Expressed on surface of HSCs


1st stem cell transplant - answer 1960's, infant with immunodeficiency disorder, matched sib


SDF-1 - answer Secreted by bone marrow stromal cells


Involved in retaining HSCs within bone marrow as well as releasing HSCs into circulation


Stem cell retention in bone marrow - answer Involves SDF-1 gradient, cellular adhesion
molecules (CAMs), and binding action of CXCR4


Myeloid progenitor cells differentiate into... - answer - RBCs
- Megakaryocyte (platelets)
- Neutrophils
- Basophils
- Eosinophils
- Monocytes/macrophages
- Dendritic cells
- Mast cells


Goals of transplant: non-malignant diseases - answer Cell line replacement

, Goals of transplant: malignant diseases - answer Tumor ablation


Graft vs. Tumor effect - answer - Promoted by withdrawal of immunosuppression
- Promoted by DLI
- Decreases in absence of GVHD


Common hematological malignancies treated with auto HSCT - answer - Hodgkin disease
- Non-Hodgkin lymphoma
- Multiple myeloma


Common hematological malignancies treated with allo HSCT - answer - ALL
- AML
- CML
- MDS
- NHL
- Juvenile myelomonocytic leukemia


Solid tumors treated with auto HSCT - answer - Neuroblastoma
- Sarcoma
- Germ cell tumors
- Brain tumors
- Ovarian cancer
- Melanoma
- Lung cancer


Common non-malignant hematologic diseases treated with allo HSCT - answer - Severe aplastic
anemia