DOAC questions with correct answers

Direct Oral Anticoagulants are a drug class that....? - Answer Directly binds to and inhibits clotting factors IIa (thrombin) or Xa What is unique about Dabigatran compared to the other 4 DOACs? - Answer Only direct thrombin inhibitor Which DOACs cannot be crushed? - Answer -Dabigatran -Edoxaban Which DOAC must be taken with food? - Answer Rivaroxaban Which DOACs inhibit factor Xa? - Answer -Apixaban -Rivaroxaban -Edoxaban Why is it significant that DOACs are P-gp substrates? - Answer P-glycoprotein (P-gp) is responsible for excretion of drugs/other molecules from gut and kidneys therefore DOACs P-gp substrates means they are susceptible to excretion. If a patient is also taking a drug that is a P-gb inhibitor along with a DOAC what does this mean for their VTE therpay? - Answer More DOAC in circulation therefore these drugs will have a larger systemic effect