Tentamenvragen deel 1 (blackboard)
Multiple choice questions
1. Metronidazole can be used to treat several parasitic infections, including
a. Filariasis
b. Malaria
c. Giardiasis
d. Trypanosomiasis
2. resistance against anti-retroviral agents develops easily because
a. The HIV genome integrates into the genome of the host cell and can therefore
easily receive new genetic material.
b. The HIV reverse transcriptase is error-prone.
c. The HIV replication cycle is slow.
d. The HIV has an envelope that prevents the drugs from entering the virus.
3. Enterococci can become resistant against vancomycin by
a. Expressing vancomycin-modifying enzymes
b. Expressing efflux pumps removing vancomycin from the cytosol
c. Altering the structure of peptidoglycan
d. Altering the thickness of peptidoglycan
4. Tigecycline is a relatively new antibiotic derived from tetracycline by chemical
modification. Which of the following statements is true?
a. Tigecycline is the only antibiotic derived from tetracycline.
b. Ribosomal protection proteins do not confer resistance against tigecycline.
c. Efflux pumps conferring resistance against tetracycline cannot use tigecycline
as a substrate.
d. In comparison to tetracycline, tigecycline has an improved activity against
gram-positive bacteria.
Open questions
1. There are several methods to determine bacterial susceptibilities. Mention at least three of
these methods and discus their advantages and disadvantages.
2. a. What is the mechanism of treatment of HBV?
b. What are the problems with this treatment?
Multiple choice questions
1. Metronidazole can be used to treat several parasitic infections, including
a. Filariasis
b. Malaria
c. Giardiasis
d. Trypanosomiasis
2. resistance against anti-retroviral agents develops easily because
a. The HIV genome integrates into the genome of the host cell and can therefore
easily receive new genetic material.
b. The HIV reverse transcriptase is error-prone.
c. The HIV replication cycle is slow.
d. The HIV has an envelope that prevents the drugs from entering the virus.
3. Enterococci can become resistant against vancomycin by
a. Expressing vancomycin-modifying enzymes
b. Expressing efflux pumps removing vancomycin from the cytosol
c. Altering the structure of peptidoglycan
d. Altering the thickness of peptidoglycan
4. Tigecycline is a relatively new antibiotic derived from tetracycline by chemical
modification. Which of the following statements is true?
a. Tigecycline is the only antibiotic derived from tetracycline.
b. Ribosomal protection proteins do not confer resistance against tigecycline.
c. Efflux pumps conferring resistance against tetracycline cannot use tigecycline
as a substrate.
d. In comparison to tetracycline, tigecycline has an improved activity against
gram-positive bacteria.
Open questions
1. There are several methods to determine bacterial susceptibilities. Mention at least three of
these methods and discus their advantages and disadvantages.
2. a. What is the mechanism of treatment of HBV?
b. What are the problems with this treatment?
