1. Biotransformation is vital in removing toxicants from the circulation. All of the
following statements regarding biotransformation are true EXCEPT:
- Many toxicants must be biotransformed into a more lipid-soluble form before
they can be excreted from the body.
2. Which of the following statements about active transport across cell
membranes is FALSE?
- Metabolic inhibitors do not affect the ability to perform active transport.
3. Which of the following might increase the toxicity of toxicants administered
orally?
- increased dilution of the toxin dose.
4. Which of the following most correctly describes the first-pass effect?
- The GI tract partially removes orally administered toxicants before they reach
systemic circulation.
5. Which of the following is an important mechanism for removing particulate
matter from the alveoli?
- absorption into the bloodstream, followed by excretion via the kidneys.
6. To be absorbed through the skin, a toxicant must pass through multiple layers
to reach the systemic circulation. Which of the following layers is the most
important in slowing the rate of toxicant absorption through the skin?
- stratum corneum.
7. A toxicant is selectively toxic to the lungs. Which of the following modes of
toxicant delivery would most likely cause the LEAST damage to the lungs?
- subcutaneous.
8. Which of the following is NOT an important site of toxicant storage in the
body?
- muscle.
9. Which of the following regarding the blood-brain barrier is TRUE:
- The degree of lipid solubility is a primary determinant of whether or not a
substance can cross the blood–brain barrier.
10. Which of the following will result in DECREASED excretion of toxic
compounds by the kidneys?
- increased activity of the organic cation transporter.
following statements regarding biotransformation are true EXCEPT:
- Many toxicants must be biotransformed into a more lipid-soluble form before
they can be excreted from the body.
2. Which of the following statements about active transport across cell
membranes is FALSE?
- Metabolic inhibitors do not affect the ability to perform active transport.
3. Which of the following might increase the toxicity of toxicants administered
orally?
- increased dilution of the toxin dose.
4. Which of the following most correctly describes the first-pass effect?
- The GI tract partially removes orally administered toxicants before they reach
systemic circulation.
5. Which of the following is an important mechanism for removing particulate
matter from the alveoli?
- absorption into the bloodstream, followed by excretion via the kidneys.
6. To be absorbed through the skin, a toxicant must pass through multiple layers
to reach the systemic circulation. Which of the following layers is the most
important in slowing the rate of toxicant absorption through the skin?
- stratum corneum.
7. A toxicant is selectively toxic to the lungs. Which of the following modes of
toxicant delivery would most likely cause the LEAST damage to the lungs?
- subcutaneous.
8. Which of the following is NOT an important site of toxicant storage in the
body?
- muscle.
9. Which of the following regarding the blood-brain barrier is TRUE:
- The degree of lipid solubility is a primary determinant of whether or not a
substance can cross the blood–brain barrier.
10. Which of the following will result in DECREASED excretion of toxic
compounds by the kidneys?
- increased activity of the organic cation transporter.
