1. Which of the following mechanisms can contribute to the development of
tolerance to a toxicant?
● increased metabolic detoxification of the toxicant
2. What is the primary role of the liver in the detoxification of chemicals?
● to biotransform chemicals into more water-soluble forms for excretion
3. Which of the following is NOT a characteristic of carcinogens?
● they have low affinity for DNA
4. Which of the following DNA lesions is NOT repaired by base excision repair?
● double strand breaks
5. Which of the following is NOT a consequence of DNA damage?
● increased transcription of oncogenes
6. Which of the following is NOT a characteristic of the mitochondria-mediated
pathway of apoptosis?
● activation of caspase-3
tolerance to a toxicant?
● increased metabolic detoxification of the toxicant
2. What is the primary role of the liver in the detoxification of chemicals?
● to biotransform chemicals into more water-soluble forms for excretion
3. Which of the following is NOT a characteristic of carcinogens?
● they have low affinity for DNA
4. Which of the following DNA lesions is NOT repaired by base excision repair?
● double strand breaks
5. Which of the following is NOT a consequence of DNA damage?
● increased transcription of oncogenes
6. Which of the following is NOT a characteristic of the mitochondria-mediated
pathway of apoptosis?
● activation of caspase-3
