1
,INHOUD
Samenvatting ......................................................................................................................... 4
summary ................................................................................................................................ 5
afkortingenlijst ........................................................................................................................ 6
1. Inleiding ........................................................................................................................... 7
2. Retro synthetische analyse .............................................................................................. 9
2.1. retro synthetische benadering ...................................................................................... 9
2.2. Toelichting retro synthetische route ........................................................................ 10
2.3. E-factor .................................................................................................................. 11
2.4. Atoom efficiëntie bij retrosynthese .......................................................................... 11
Conclusie .......................................................................................................................... 11
3. Keuzeproces synthese routes ........................................................................................ 12
3.1. Synthese methode en refentie keuzes.................................................................... 12
Conclusie .......................................................................................................................... 14
4. Uitwerking synthese route .............................................................................................. 15
4.1. Synthese route ....................................................................................................... 15
4.2. uitleg van de gekozen synthese route .................................................................... 16
Conclusie .......................................................................................................................... 16
5. Conclusie ....................................................................................................................... 17
aanbevelingen ...................................................................................................................... 18
6. Bronnen ......................................................................................................................... 19
7. Bijlage1 – Syntheses en synthese mechanismen........................................................... 21
2
, OPDRACHT
3
,INHOUD
Samenvatting ......................................................................................................................... 4
summary ................................................................................................................................ 5
afkortingenlijst ........................................................................................................................ 6
1. Inleiding ........................................................................................................................... 7
2. Retro synthetische analyse .............................................................................................. 9
2.1. retro synthetische benadering ...................................................................................... 9
2.2. Toelichting retro synthetische route ........................................................................ 10
2.3. E-factor .................................................................................................................. 11
2.4. Atoom efficiëntie bij retrosynthese .......................................................................... 11
Conclusie .......................................................................................................................... 11
3. Keuzeproces synthese routes ........................................................................................ 12
3.1. Synthese methode en refentie keuzes.................................................................... 12
Conclusie .......................................................................................................................... 14
4. Uitwerking synthese route .............................................................................................. 15
4.1. Synthese route ....................................................................................................... 15
4.2. uitleg van de gekozen synthese route .................................................................... 16
Conclusie .......................................................................................................................... 16
5. Conclusie ....................................................................................................................... 17
aanbevelingen ...................................................................................................................... 18
6. Bronnen ......................................................................................................................... 19
7. Bijlage1 – Syntheses en synthese mechanismen........................................................... 21
2
, OPDRACHT
3
