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Risk Factors of Type 2 Diabetes Contribute to The Progression of
Coronary Artery Disease and Peripheral Artery Disease
Abstract
Type 2 Diabetes patients are potentially at a higher risk of developing and
progressing artery diseases. However, it is known that both conditions appear to be
asymptomatic to a great extent, creating challenges to the current scientific world. In
this report, the correlation between type 2 diabetes and the progression of artery
diseases was examined by collecting data from different studies. The studies indicated
that long diabetic duration and excessive levels of RBP-4 led to coronary artery disease
(CAD), along with high systolic blood pressure and being overweight reinforced
peripheral artery disease (PAD). From the investigated studies, it can be confirmed that
risk factors of type 2 diabetes progress CAD and PAD.
Introduction
Coronary artery disease (CAD) and peripheral artery disease (PAD) are
conditions that affect the arteries. Both CAD and PAD affect the arteries that transport
blood to the heart and the arteries that carry the blood away from the heart,
respectively. On the other hand, type 2 diabetes (T2D) appears as a result of either the
damaged insulin flow through the body or the insufficient feedback to secreted insulin.
Of all the known T2D patients, 75% of them die as a result of a co-existent
cardiovascular disease (Naito & Kasai, 2015). Previous research of Naito et al. (2017)
has shown that T2D is a significant risk factor affecting CAD. T2D patients are more
likely to endure the more complex form of CAD. According to another study, evidence
was found that diabetes progresses the potentiality of lower-extremity amputation. This
highlights the increased mortality rate among diabetics, in relation to non-diabetics
(Naidoo et al., 2015). The existence of both T2D and CAD and PAD have more crucial
and severe outcomes, relative to if solely one of the diseases is present. However, the
prevalence of the PAD in diabetic patients has been challenging to determine.
Profoundly, this is due to the patients who do not experience symptoms, making them
substantially asymptomatic (Soyoye et al., 2015). It is common for diabetic patients to
have peripheral complications including the involvement of the vessels of the lower
extremity, causing them not to interpret classic claudication pain and thus fail to
sufficiently address the symptoms of PAD. Similarly, asymptomatic CAD is also
relatively prevalent posing difficulties to the scientific world. Currently there is no solid
algorithm to screen for silent CAD in diabetics (Ashraf et al., 2014). Therefore, this
paper investigates the correlation between T2D patients and the progression of artery
diseases. In order to be able to draw conclusions, this study will focus on how T2D
contributes to the progression of two artery diseases: CAD and PAD.
IR and Diabetic Duration Promotes the Advancement of CAD
Risk Factors of Type 2 Diabetes Contribute to The Progression of
Coronary Artery Disease and Peripheral Artery Disease
Abstract
Type 2 Diabetes patients are potentially at a higher risk of developing and
progressing artery diseases. However, it is known that both conditions appear to be
asymptomatic to a great extent, creating challenges to the current scientific world. In
this report, the correlation between type 2 diabetes and the progression of artery
diseases was examined by collecting data from different studies. The studies indicated
that long diabetic duration and excessive levels of RBP-4 led to coronary artery disease
(CAD), along with high systolic blood pressure and being overweight reinforced
peripheral artery disease (PAD). From the investigated studies, it can be confirmed that
risk factors of type 2 diabetes progress CAD and PAD.
Introduction
Coronary artery disease (CAD) and peripheral artery disease (PAD) are
conditions that affect the arteries. Both CAD and PAD affect the arteries that transport
blood to the heart and the arteries that carry the blood away from the heart,
respectively. On the other hand, type 2 diabetes (T2D) appears as a result of either the
damaged insulin flow through the body or the insufficient feedback to secreted insulin.
Of all the known T2D patients, 75% of them die as a result of a co-existent
cardiovascular disease (Naito & Kasai, 2015). Previous research of Naito et al. (2017)
has shown that T2D is a significant risk factor affecting CAD. T2D patients are more
likely to endure the more complex form of CAD. According to another study, evidence
was found that diabetes progresses the potentiality of lower-extremity amputation. This
highlights the increased mortality rate among diabetics, in relation to non-diabetics
(Naidoo et al., 2015). The existence of both T2D and CAD and PAD have more crucial
and severe outcomes, relative to if solely one of the diseases is present. However, the
prevalence of the PAD in diabetic patients has been challenging to determine.
Profoundly, this is due to the patients who do not experience symptoms, making them
substantially asymptomatic (Soyoye et al., 2015). It is common for diabetic patients to
have peripheral complications including the involvement of the vessels of the lower
extremity, causing them not to interpret classic claudication pain and thus fail to
sufficiently address the symptoms of PAD. Similarly, asymptomatic CAD is also
relatively prevalent posing difficulties to the scientific world. Currently there is no solid
algorithm to screen for silent CAD in diabetics (Ashraf et al., 2014). Therefore, this
paper investigates the correlation between T2D patients and the progression of artery
diseases. In order to be able to draw conclusions, this study will focus on how T2D
contributes to the progression of two artery diseases: CAD and PAD.
IR and Diabetic Duration Promotes the Advancement of CAD
