Pharmacology Unit 1 Questions

Pharmacology Unit 1 Questions Properties of an ideal drug effectiveness, safety, selectivity, reversible action, predictability, ease of administration, freedom from drug interactions, low cost, chemical stability, simple generic name Factors affecting intensity of drug response Administration route, pharmacokinetics, pharmacodynamics, sources of individual variation Absorption Movement of a drug from its sight of administration into the blood Distribution Drug movement from the blood, to the interstitial space of the tissues and finally into the cells Blood-brain barrier Unique anatomy of capillaries in the CNS. Composed of tight junctions that prevent drug passage. Drug must be lipid-soluble or have a transport system to pass through. Protein-Binding Drugs can form reversible bonds. Most important is albumin because drugs bound to it are unable to leave the bloodstream Metabolism Chemical alteration of the drug structure. Usually takes place in the liver