NUR2474 Pharmacology Module 3 Quiz Review

Test tips: Be cautious of negatively worded questions! They are easy, but often misinterpreted due to not paying attention to them. Topics review: 1. General features of schizophrenia and Chlorpromazine (class, mechanism of action, adverse effects, administration/withdrawal teaching, and review early and late EPS specifically). a. Chlorpromazine . i. Class: Antipsychotic (low-potency) ii. Mechanism of action: blocks dopamine. Many cause serious movement disorders known as (Extrapyramidal symptoms EPS). None if the Schizophrenia medications are addictive. Suppress symptoms during acute psychotic episodes. iii. Adverse effects (First Generation Antipsychotics) 1. EPS 2. Neuroleptic malignant syndrome: Risk of death without treatment due to cardiovascular collapse & dysrhythmias. a. “Lead pipe” rigidity, sudden high fever, sweating, autonomic instability, dysrhythmias, fluctuations in blood pressure, altered level of consciousness, and seizures or coma may develop. 3. Parkinsonism: Bradykinesia, mask-like facies, drooling, tremor, rigidity, shuffling gait, cogwheeling, and stooped posture. 4. Akathisia: Pacing and squirming brought on by an uncontrollable need to be in motion. 5. Tardive Dyskinesia: Choreoathetoid movements of the tongue and face; lip-smacking movements; tongue flicks out in a “fly- catching” motion; slow, worm-like movement of the tongue; and involuntary movements of the limbs, toes, fingers, and trunk iv. Administration/withdrawal teaching 1. Contraindications a. Parkinson’s Disease because it further reduces dopamine. Levodopa counteracts antipsychotic effects. v. Early and late EPS 1. What causes it a. Taking first or second generation antipsychotic drugs that antagonize dopamine receptors. 2. Symptoms (first generation drugs) a. Acute dystonia: involuntary muscle contractions that may cause repetitive twisting movements.