BioChem C785 / Biochemistry Unit 4

Biochemistry – C785 Unit 4 Quiz 1. Which of the following could be a potential ramification of a defective nucleotide excision repair (NER) pathway? a. Thymine dimers would accumulate and increase the probability of developing skin cancer. 2. A patient has received a large dose of ionizing radiation at his place of employment. Which scenario is accurate? a. Double-stranded DNA breaks are being repaired by nonhomologous end joining, without the use of a homologous template. 3. Immediately following transcription, mRNA must be processed before it is transported to the cytoplasm to undergo translation. Which statement correctly describes mRNA processing? a. Introns are spliced out and exons are connected to produce a mature mRNA sequence. 4. A point mutation has altered the amino acid sequence of a neuronal tau protein, causing serine (Ser) at position 202 to be mutated to proline (Pro). Which set of codons below corresponds to this mutation? a. TCT to CCT 5. Which of the following is required for DNA polymerase to replicate template DNA in PCR? a. DNA primers 6. A portion of the HLA gene and its associated amino acid sequence are shown below. If cytosine is deleted from codon 101, what will be the resulting amino acid sequence?