Flaviviridae
- Enveloped positive-strand RNA viruses which mainly infect mammals and birds
- Primarily spread by arthropod vectors, such as ticks and mosquitoes
- Over 89 species in the family divided into four genera of viruses: Flavivirus, Hepacivirus,
Pegivirus and Pestivirus
- Associated diseases include hepatitis, hemorrhagic fever, fatal mucosal disease,
encephalitis and microcephaly
- Viral replication is cytoplasmic, host cell entry occurs through attachment of viral envelope
protein E to host receptors, initiating clathrin-mediated endocytosis
Flavivirus
- This genus includes West Nile virus, dengue virus, tick-borne encephalitis, yellow fever
virus and Zika virus
- Named after yellow fever virus, which is known for its tendency to cause yellow jaundice in
mammalian hosts
- Common features include a symmetrical shape (enveloped, icosahedral nucleocapsid) and
SS-RNA nucleic acid
- Most flaviviruses are transmitted by the bites of infected arthropods such as mosquitoes
and ticks, and are hence classified as arboviruses
- Human infection is mostly incidental, and humans are a dead-end host, as the virus is
unable to replicate at a high enough level to reinfect arthropods. The obvious exceptions to
this are yellow fever virus, zika virus and dengue virus
Hepacivirus
- This genus includes the Hepatitis C virus, which is associated with hepatitis and
hepatocellular carcinoma
Pegivirus
- Single stranded RNA viruses, whose name refers to Hepatitis G, a former name of the C
species
- Associated diseases include GB virus C, Equine Pegivirus (EPgV) and human Pegivirus
type 2
- Enveloped positive-strand RNA viruses which mainly infect mammals and birds
- Primarily spread by arthropod vectors, such as ticks and mosquitoes
- Over 89 species in the family divided into four genera of viruses: Flavivirus, Hepacivirus,
Pegivirus and Pestivirus
- Associated diseases include hepatitis, hemorrhagic fever, fatal mucosal disease,
encephalitis and microcephaly
- Viral replication is cytoplasmic, host cell entry occurs through attachment of viral envelope
protein E to host receptors, initiating clathrin-mediated endocytosis
Flavivirus
- This genus includes West Nile virus, dengue virus, tick-borne encephalitis, yellow fever
virus and Zika virus
- Named after yellow fever virus, which is known for its tendency to cause yellow jaundice in
mammalian hosts
- Common features include a symmetrical shape (enveloped, icosahedral nucleocapsid) and
SS-RNA nucleic acid
- Most flaviviruses are transmitted by the bites of infected arthropods such as mosquitoes
and ticks, and are hence classified as arboviruses
- Human infection is mostly incidental, and humans are a dead-end host, as the virus is
unable to replicate at a high enough level to reinfect arthropods. The obvious exceptions to
this are yellow fever virus, zika virus and dengue virus
Hepacivirus
- This genus includes the Hepatitis C virus, which is associated with hepatitis and
hepatocellular carcinoma
Pegivirus
- Single stranded RNA viruses, whose name refers to Hepatitis G, a former name of the C
species
- Associated diseases include GB virus C, Equine Pegivirus (EPgV) and human Pegivirus
type 2
