UAMS Hematology lab final Exam Verified Questions and Correct Answers (2025/2026)

UAMS Hematology lab final Exam Verified
Questions and Correct Answers (2025/2026)
UAMS College of Health Professions
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Department of Laboratory Sciences cx cx cx




Hematology Laboratory Final Examination cx cx cx




Total Points: 100 cx cx



Time Allowed: 2 Hours
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Instructions: Please select the single best answer for each question. Mark your answers on the Scantron
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sheet provided.
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Section I: Cell Morphology & Identification (25 Questions)
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1. A peripheral blood smear from a patient with a severe infection shows large, dark blue-
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purple granules in the cytoplasm of segmented neutrophils. These structures are most consistent wit
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h:

• A. Auer rods
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• B. Döhle bodies
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• C. Toxic granulation
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• D. Howell-Jolly bodies
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2. Which of the following red blood cell (RBC) inclusions is composed of denatured hemoglobin and is
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visualized with a supravital stain such as new methylene blue?
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• A. Pappenheimer bodies
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• B. Heinz bodies
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• C. Basophilic stippling
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• D. Cabot rings
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3. A patient with a history of splenectomy presents with numerous spherical, densely staining red blo
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od cells lacking central pallor. These cells are best described as:
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• A. Schistocytes
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• B. Acanthocytes
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• C. Spherocytes
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, • D. Target cells
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4. The presence of numerous schistocytes on a peripheral smear is most indicative of:
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• A. Iron deficiency anemia
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• B. Thalassemia trait
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• C. Microangiopathic hemolytic anemia (e.g., TTP/HUS)
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• D. Liver disease
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5. A Wright-Giemsa stained smear shows a cell with a high nuclear-to-
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cytoplasmic (N:C) ratio, a round nucleus with fine chromatin, and prominent nucleoli. The cytoplasm i
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s deeply basophilic with no granules. This cell is most likely a:
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• A. Myeloblast
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• B. Promyelocyte
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• C. Myelocyte
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• D. Lymphoblast
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6. The maturation stage of the granulocytic series characterized by the appearance of specific second
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ary granules and a kidney-bean shaped nucleus is the:
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• A. Metamyelocyte
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• B. Band cell
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• C. Myelocyte
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• D. Promyelocyte
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7. A peripheral smear shows numerous oval macrocytes and hypersegmented neutrophils. This morp
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hology is most consistent with:
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• A. Iron deficiency anemia
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• B. Megaloblastic anemia (Vitamin B12/Folate deficiency)
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• C. Anemia of chronic disease
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• D. Sickle cell anemia
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8. Reactive lymphocytes (Downey cells) with abundant, pale blue cytoplasm that appears to "hug" adj
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acent red blood cells are most characteristic of:
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• A. Chronic Lymphocytic Leukemia (CLL)
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• B. Infectious Mononucleosis
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• C. Bacterial sepsis
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, • D. Hodgkin's Lymphoma
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9. The presence of a "smudge cell" or "basket cell" on a peripheral smear is often associated with whi
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ch disorder?
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• A. Acute Myeloid Leukemia (AML)
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• B. Chronic Lymphocytic Leukemia (CLL)
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• C. Hairy Cell Leukemia
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• D. Multiple Myeloma
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10. Which of the following is a characteristic finding in a patient with Sickle Cell Disease (HbSS) during
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a vaso-occlusive crisis?
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• A. Numerous target cells
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• B. Absence of Howell-Jolly bodies
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• C. Sickle cells, schistocytes, and polychromasia
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• D. Marked rouleaux formation
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11. The Wright stain is a mixture of which two types of dyes?
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• A. Methylene blue and eosin
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• B. Crystal violet and safranin
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• C. Basic fuchsin and malachite green
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• D. Hematoxylin and orange G
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12. A cell has a diameter of approximately 15 µm, a round nucleus with clumped chromatin, and abun
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dant gray-blue cytoplasm with pale, peripheral vacuoles. This cell is most likely a:
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• A. Plasma cell
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• B. Monocyte
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• C. Prolymphocyte
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• D. Reactive lymphocyte
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13. The platelet count is spuriously low on an EDTA specimen. Which of the following would be the m
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ost appropriate next step?
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• A. Report the count as is.
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• B. Perform a platelet count from a blue-top (sodium citrate) tube and correct for the dilution.
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• C. Warm the specimen to 37°C.
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• D. Perform a manual platelet count using a hemocytometer from a green-top (heparin) tube.
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, 14. Which of the following cells is the precursor to the tissue macrophage?
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• A. Promonocyte
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• B. Myeloblast
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• C. Lymphoblast
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• D. Megakaryoblast
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15. The presence of a "myelocyte bulge" or "left shift" on a peripheral smear refers to an increase in:
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• A. Band neutrophils
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• B. Segmented neutrophils
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• C. Immature granulocytic precursors
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• D. Lymphocytes
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Section II: Laboratory Principles, Instrumentation, & Automation (15 Questions)
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16. In the impedance (Coulter) method of cell counting, cells are counted based on:
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• A. The amount of light they scatter.
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• B. The electrical current they disrupt as they pass through an aperture.
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• C. The intensity of fluorescence after staining with a dye.
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• D. The time it takes for them to pass through a laser beam.
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17. The principle of flow cytometry is based on the use of:
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• A. Light scatter and fluorescence
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• B. Electrical impedance
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• C. Viscosity changes
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• D. Centrifugal force
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18. A CBC is ordered on a patient. Which of the following tube types is the standard and preferred spe
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cimen for a complete blood count?
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• A. Light blue top (Sodium Citrate)
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• B. Lavender top (EDTA)
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• C. Green top (Heparin)
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• D. Red top (No additive)
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19. The International Normalized Ratio (INR) was developed to standardize results of which test?
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