Newest Version A With Complete Questions &
Accurate Detailed Answers (Verified 100%)
Already Graded A+
Controlled ovarian stimulation
GnRH agonist/antagonists suppresses FSH and LH, then FSH
injections followed by single hCG injection to simulate LH surge
Suppression of meiosis
GPR3 converts ATP into cAMP, increased cAMP triggers cascade
with PKA to keep CyB and CDK1 bound = MPF inactive
Granulosa aid in suppression of meiosis
Extra cAMP to keep levels high, cGMP to inhibit PDE3A antagonistic
pathway
Theca aid in suppression of meiosis
Purines to inhibit PDE3A antagonistic pathway
,Resumption of meiosis
LH surge causes EGF-like signals to breakdown gap junctions so theca
and granulosa no longer suppress, PDE3A pathway dominant
BMP15
Fecundity gene where +/- had triplets, causes stunted granulosa so
need multiple follicles to cause LH surge
Oocyte secreted factors role
Inhibit lutenisation, stimulate theca and granulosa proliferation + FSH
receptor expression, identity of granulosa.
Oocyte DNA changes
Gene transcription slows, euchromatin decreases and
heterochromatin increases
mRNA stored in oocyte for
Meiosis resumption, embryo cell division, sperm processing, basic cell
maintenance, genome activation
Indifferent genital development
At 6-8 weeks both XX and XY have mesonephric and paramesonephric
ducts
,Paramesonephric duct differentiates into
Oviducts, uterus, cervix, and upper 1/3 of the vagina
Paramesonephric duct development
Cranially, unfused portion forms uterine tubes.
Caudally, fused portion forms uterovaginal canal
Uterine epithelium formation
Primitive luminal epithelial appears ~week 10 gestation
Endometrial gland formation
Begin to form 14-15 weeks, by 21 they're elongated and branched
Myometrium formation
Differentiation begins 8-9 weeks, distinct by 18 weeks
Duplex uterus
Uterine horns with two cervices
Bipartite uterus
Uterine horns with a single cervix
, Bicornuate uterus
Uterine body and horns with a single cervix
Simplex uterus
Single uterine body with a single cervix
Congenital uterine variation
Divergence from PMD/uterine development causing variation in uterine
morphology
Hysterosalpingography
Radiographic evaluation of uterus + tubes using opaque contrast
Menarche
The first menstrual period occurring as part of female puberty
Menopause
Cessation of menstrual periods occurring as part of climateric