MIMG 185 Final Exam Questions and Verified Correct Answers 2026/2027

MIMG 185 Final Exam Questions and Verified Correct Answers 2026/2027 What role does B cells play in? - Correct Answer - Innate and adaptive immunity What are the 3 known subsets of B cells and what immunity do they play in? - Correct Answer - B1: Innate immunity - B2 (conventional): Adaptive Immunity - Marginal Zone B cells: Innate and Adaptive immunity What subsets is B-1 B cells divided into and what do they both contain? - Correct Answer - B-1a expressing protein CD5 - B-1b that do not express CD5 - Both are high in IgM - Important to know B-1 B cells sometimes express CD5 (marker for T cells) Describe B-1 B cells and their location? - Correct Answer - Long-lived and self-renewing - Develops early in ontogeny from fetal omentum and liver - After birth, stems cell for B-1 are NOT present in bone marrow - In adults, they are found predominately in peritoneal and pleural cavities - Rare in spleen and absent from lymph node and peripheral blood Describe the variability of the B-1 B cells and what they produce - Correct Answer - Limited V region repertoire - Lots of self-reactivity - Recognition of bacterial antigens (phosphorylcholine) - Broad specificity and low affinity - Produce specifities encoded in germline with no N region insertion and little somatic mutation - Produce large amounts of antibody (50% of all antibodies in serume) - Responsible for majority of non-immune serum IgM and constribute to resting IgA - If you immunize your reaction, there will be IgM present that is non-immune cause of B-1 B cells What type of responses does B-1 B cells have and do they require T cell help? - Correct Answer - Does not requi