Medical-Surgical Nursing MCQs Study Guide & Practice Question Bank

Harrison's Principles of Internal Medicine
(Vol.1 & Vol.2)
22nd Edition
• Author(s)Joseph Loscalzo; Anthony S.
Fauci; Dennis L. Kasper; Stephen Hauser;
Dan Longo; J. Larry Jameson
Test Bank




Covered

PART 1: Foundations of Clinical Medicine

PART 2: Cardinal Symptoms & Clinical Presentations

PART 3: Clinical Pharmacology

PART 4: Oncology & Hematology

PART 5: Infectious Diseases

PART 6: Cardiovascular Disorders

PART 7: Respiratory Disorders

PART 8: Critical Care Medicine

PART 9: Kidney & Urinary Tract Disorders

PART 10: Gastrointestinal & Hepatobiliary Disorders

,PART 11: Immune-Mediated & Rheumatologic Disorders

PART 12: Endocrinology & Metabolism

PART 13: Neurologic & Psychiatric Disorders

PART 14: Toxicology & Environmental Injury

PART 15: Environmental & Occupational Medicine

PART 16: Genetics, Precision & Systems Medicine

PART 17–20: Special & Emerging Topics




1. The primary goal of evidence-based clinical decision-making
in modern medical practice is to:
A. Replace clinical judgment with standardized protocols
B. Integrate best research evidence with clinical expertise and
patient values
C. Minimize health care costs regardless of outcomes
D. Prioritize physician experience over patient preferences
Correct Answer: B
Rationale: Harrison emphasizes that optimal clinical care results
from integrating high-quality evidence, clinician expertise, and
individual patient values—not from rigid protocols alone.
Citation: Harrison’s Principles of Internal Medicine, 22nd ed.,
Chapter 1 – The Practice of Medicine

,2. Which nursing action best supports disease prevention at
the population level?
A. Early initiation of palliative care
B. Identification of genetic mutations
C. Implementation of evidence-based screening programs
D. Use of advanced diagnostic imaging
Correct Answer: C
Rationale: Screening and preventive strategies reduce
morbidity and mortality by detecting disease at asymptomatic
or early stages.
Citation: Harrison’s Principles of Internal Medicine, 22nd ed.,
Chapter 6 – Screening and Prevention of Disease


3. Vaccine hesitancy is most commonly driven by:
A. Lack of vaccine availability
B. Mistrust, misinformation, and perceived risk
C. Religious doctrine alone
D. Prior vaccine contraindications
Correct Answer: B
Rationale: Harrison identifies misinformation, mistrust in
institutions, and exaggerated safety concerns as major
contributors to vaccine opposition.
Citation: Harrison’s Principles of Internal Medicine, 22nd ed.,
Chapter 3 – Vaccine Opposition and Hesitancy

, 4. A nurse supporting shared decision-making should
prioritize:
A. Providing only clinician-preferred options
B. Limiting patient involvement to consent
C. Clear communication of risks, benefits, and alternatives
D. Avoiding uncertainty in discussions
Correct Answer: C
Rationale: Shared decision-making requires transparent
discussion of options aligned with patient goals and values.
Citation: Harrison’s Principles of Internal Medicine, 22nd ed.,
Chapter 4 – Decision-Making in Clinical Medicine


5. Precision medicine primarily differs from traditional care by
its focus on:
A. Population-level disease trends
B. Uniform treatment protocols
C. Individual variability in genes, environment, and lifestyle
D. Symptom-based diagnosis only
Correct Answer: C
Rationale: Precision medicine tailors prevention and treatment
based on individual biological and environmental differences.
Citation: Harrison’s Principles of Internal Medicine, 22nd ed.,
Chapter 5 – Precision Medicine and Clinical Care