TEST BANK
YT
Cellular and Molecular Immunology
YT YT YT
Abul Abbas, Andrew Lichtman, and Shiv Pillai
YT YT YT YT YT YT
10th Edition
YT
,Table of Contents
YT YT
ChapterYT01YTPropertiesYTandYTOverviewYTofYTImmuneYTResponses 1
ChapterYT02YTCellsYTandYTTissuesYTofYTtheYTImmuneYTSystem 3
ChapterYT03YTLeukocyteYTCirculationYTandYTMigrationYTIntoYTTissues 6
ChapterYT04YTInnateYTImmunity 10
ChapterYT05YTAntibodiesYTandYTAntigens 17
ChapterYT06YTAntigenYTPresentationYTtoYTTYTLymphocytesYTandYTtheYTFunctionsYTofYTMajor
HistocompatibilityYTComplexYT Molecules 20
ChapterYT07YTImmuneYTReceptorsYTandYTSignalYTTransduction 27
ChapterYT08YTLymphocyteYTDevelopmentYTandYTAntigenYTReceptorYTGeneYTRearrangement 30
ChapterYT09YTActivationYTofYTTYTLymphocytes 34
ChapterYT10YTDifferentiationYTandYTFunctionsYTofYTCD4+YTEffectorYTTYTCells 38
ChapterYT11YTDifferentiationYTandYTFunctionsYTofYTCD8+YTEffectorYTTYTCells 42
ChapterYT12YTBYTCellYTActivationYTandYTAntibodyYTProduction 46
ChapterYT13YTEffectorYTMechanismsYTofYTHumoralYTImmunity 52
ChapterYT14YTSpecializedYTImmunityYTatYTEpithelialYTBarriersYTandYTinYTImmuneYTPrivilegedYTTissues 56
ChapterYT15YTImmunologicYTToleranceYTandYTAutoimmunity 62
ChapterYT16YTImmunityYTtoYTMicrobes 67
ChapterYT17YTTransplantationYTImmunology 72
ChapterYT18YTTumorYTImmunology 77
ChapterYT19YTHypersensitivityYTDisorders 81
ChapterYT20YTAllergy 86
ChapterYT21YTPrimaryYTandYTAcquiredYT Immunodeficiencies 89
,Chapter 01: Properties and Overview of Immune Responses
YT YT YT YT YT YT YT
Abbas, Lichtman, and Pillai: Cellular and Molecular Immunology, 10th Edition
YT YT YT YT YT YT YT YT YT
MULTIPLEYTCHOICE
1. TheYTprincipalYTfunctionYTofYTtheYTimmuneYTsystemYTis:
a. DefenseYTagainstYTcancer
b. RepairYTofYTinjuredYTtissues
c. DefenseYTagainstYTmicrobialYTinfections
d. PreventionYTofYTinflammatoryYTdiseases
e. ProtectionYTagainstYTenvironmentalYTtoxins
ANS:Y T C
TheYTimmuneYTsystemYThasYTevolvedYTinYTtheYTsettingYTofYTselectiveYTpressuresYTimposedYTbyYT
microbialYTinfections.YTAlthoughYTimmuneYTresponsesYTtoYTcancerYTmayYToccur,YTtheYTconcept
YTthatYT“immunosurveillance”YTagainstYTcancerYTisYTaYTprincipalYTfunctionYTofYTtheYTimmuneYTs
ystemYTisYTcontroversial.YTRepairYTofYTinjuredYTtissuesYTmayYTbeYTaYTsecondaryYTconsequenceYT
ofYTtheYTimmuneYTresponsesYTandYTinflammation.YTAlthoughYTtheYTimmuneYTsystemYThasYTregu
latoryYTfeaturesYTthatYTareYTneededYTtoYTpreventYTexcessiveYTinflammation,YTpreventionYTofYTinf
lammatoryYTdiseasesYTisYTnotYTaYTprimaryYTfunction.YTTheYTimmuneYTsystemYTcanYTprotectYTagai
nstYTmicrobialYTtoxins,YTbutYTitYTgenerallyYTdoesYTnotYTofferYTprotectionYTagainstYTtoxinsYTofYTno
nbiologicYTorigin.
2. WhichYTofYTtheYTfollowingYTinfectiousYTdiseasesYTwasYTpreventedYTbyYTtheYTfirstYTsu
ccessfulYTvaccination?
a. Polio
b. Tuberculosis
c. Smallpox
d. Tetanus
e. Rubella
ANS:Y T C
InYT1798,YTEdwardYTJennerYTreportedYTtheYTfirstYTintentionalYTsuccessfulYTvaccination,YTwhichY
TwasYTagainstYTsmallpoxYTinYTaYTboy,YTusingYTmaterialYTfromYTtheYTcowpoxYTpustulesYTofYTaYTmilk
maid.YTInYT1980,YTsmallpoxYTwasYTreportedYTtoYTbeYTeradicatedYTworldwideYTbyYTaYTvaccination
YTprogram.YTEffectiveYTvaccinesYTagainstYTtetanusYTtoxin,YTrubellaYTvirus,YTandYTpoliovirusYTwe
reYTdevelopedYTinYTtheYT20thYTcenturyYTandYTareYTwidelyYTused.YTThereYTisYTnoYTeffectiveYTvacci
neYTagainstYTMycobacteriumYTtuberculosis.
3. WhichYTofYTtheYTfollowingYTisYTaYTuniqueYTpropertyYTofYTtheYTadaptiveYTimmuneYTsystem?
a. HighlyYTdiverseYTrepertoireYTofYTspecificitiesYTforYTantigens
b. Self-nonselfYTdiscrimination
c. RecognitionYTofYTmicrobialYTstructuresYTbyYTbothYTcell-associatedYTandYTsolubleYTreceptors
d. ProtectionYTagainstYTviralYTinfections
e. ResponsesYTthatYThaveYTtheYTsameYTkineticsYTandYTmagnitudeYTonYTrepeatedYTexposur
eYTtoYTtheYTsameYTmicrobe
ANS:Y T A
, HighlyYTdiverseYTrepertoiresYTofYTspecificitiesYTforYTantigensYTareYTfoundYTonlyYTinYTTYTandYTBYT
lymphocytes,YTwhichYTareYTtheYTcentralYTcellularYTcomponentsYTofYTtheYTadaptiveYTimmuneYTsy
stem.YTBothYTtheYTinnateYTandYTtheYTadaptiveYTimmuneYTsystemsYTuseYTcell-
associatedYTandYTsolubleYTreceptorsYTtoYTrecognizeYTmicrobes,YTdisplayYTsomeYTdegreeYTofYTself
-
nonselfYTdiscrimination,YTandYTprotectYTagainstYTviruses.YTOnYTrepeatedYTexposureYTtoYTtheYTsa
meYTmicrobe,YTtheYTadaptiveYTimmuneYTresponseYTbecomesYTmoreYTrapidYTandYTofYTgreaterYTma
gnitude;YTthisYTisYTtheYTmanifestationYTofYTmemory.
4. AntibodiesYTandYTTYTlymphocytesYTareYTtheYTrespectiveYTmediatorsYTofYTwhichYTtwoYTt
ypesYTofYTimmunity?
a. InnateYTandYTadaptive
b. PassiveYTandYTactive
c. SpecificYTandYTnonspecific
d. HumoralYTandYTcell-mediated
e. AdultYTandYTneonatal
ANS:Y T D
BothYTBYTandYTTYTlymphocytesYTareYTprincipalYTcomponentsYTofYTadaptiveYTimmunity.YTBYTlymp
hocytesYTproduceYTantibodies,YTwhichYTareYTtheYTrecognitionYTandYTeffectorYTmoleculesYTofYThu
moralYTimmuneYTresponsesYTtoYTextracellularYTpathogens.YTTYTcellsYTrecognizeYTandYTpromoteYT
eradicationYTofYTintracellularYTpathogensYTinYTcell-
mediatedYTimmunity.YTPassiveYTandYTactiveYTimmunityYTbothYTcanYTbeYTmediatedYTbyYTeitherYTBYT
orYTTYTlymphocytes.YTSpecificYTimmunityYTisYTanotherYTtermYTforYTadaptiveYTimmunity.YTBothYTB
YTandYTTYTlymphocytesYTparticipateYTinYTadultYTadaptiveYTimmunityYTbutYTareYTstillYTdevelopingYT
inYTtheYTneonatalYTperiod.
5. TheYTtwoYTmajorYTfunctionalYTclassesYTofYTeffectorYTTYTlymphocytesYTare:
a. HelperYTTYTlymphocytesYTandYTcytotoxicYTTYTlymphocytes
b. NaturalYTkillerYTcellsYTandYTcytoWtoWxW
ic.TTlB
yS
mMph.oW
cyStes
c. MemoryYTTYTcellsYTandYTeffectorYTTYTcells
d. HelperYTcellsYTandYTantigen-presentingYTcells
e. CytotoxicYTTYTlymphocytesYTandYTtargetYTcells
ANS:Y T A
TYTcellsYTcanYTbeYTclassifiedYTintoYTeffectorYTsubsetsYTthatYTperformYTdifferentYTeffectorYTfunctio
ns.YTMostYTeffectorYTTYTcellsYTareYTeitherYThelperYTTYTlymphocytes,YTwhichYTenhanceYTtheYTresp
onsesYTofYTotherYTimmuneYTcells,YTincludingYTphagocytesYTandYTBYTcells,YTtoYTinfections,YTorYTc
ytotoxicYTTYTlymphocytes,YTwhichYTdirectlyYTkillYTinfectedYTcells.YTNaturalYTkillerYTcellsYTareYT
notYTTYTlymphocytes.
Antigen-
presentingYTcellsYTusuallyYTareYTnotYTTYTcells.YTMemoryYTTYTcellsYTareYTnotYTeffectorYTTYTcells.
6. WhichYTofYTtheYTfollowingYTcellYTtypesYTisYTrequiredYTforYTallYTadaptiveYThumoralYTimmuneYTresponse
s?
a. NaturalYTkillerYTcells
b. DendriticYTcells
c. CytolyticYTTYTlymphocytes
d. BYTlymphocytes
e. HelperYTTYTlymphocytes
ANS:Y T D
HumoralYTimmuneYTresponsesYTareYTantibody-
mediatedYTimmuneYTresponses,YTandYTallYTantibodiesYTareYTmadeYTbyYTBYTlymphocytesYTandYT
YT
Cellular and Molecular Immunology
YT YT YT
Abul Abbas, Andrew Lichtman, and Shiv Pillai
YT YT YT YT YT YT
10th Edition
YT
,Table of Contents
YT YT
ChapterYT01YTPropertiesYTandYTOverviewYTofYTImmuneYTResponses 1
ChapterYT02YTCellsYTandYTTissuesYTofYTtheYTImmuneYTSystem 3
ChapterYT03YTLeukocyteYTCirculationYTandYTMigrationYTIntoYTTissues 6
ChapterYT04YTInnateYTImmunity 10
ChapterYT05YTAntibodiesYTandYTAntigens 17
ChapterYT06YTAntigenYTPresentationYTtoYTTYTLymphocytesYTandYTtheYTFunctionsYTofYTMajor
HistocompatibilityYTComplexYT Molecules 20
ChapterYT07YTImmuneYTReceptorsYTandYTSignalYTTransduction 27
ChapterYT08YTLymphocyteYTDevelopmentYTandYTAntigenYTReceptorYTGeneYTRearrangement 30
ChapterYT09YTActivationYTofYTTYTLymphocytes 34
ChapterYT10YTDifferentiationYTandYTFunctionsYTofYTCD4+YTEffectorYTTYTCells 38
ChapterYT11YTDifferentiationYTandYTFunctionsYTofYTCD8+YTEffectorYTTYTCells 42
ChapterYT12YTBYTCellYTActivationYTandYTAntibodyYTProduction 46
ChapterYT13YTEffectorYTMechanismsYTofYTHumoralYTImmunity 52
ChapterYT14YTSpecializedYTImmunityYTatYTEpithelialYTBarriersYTandYTinYTImmuneYTPrivilegedYTTissues 56
ChapterYT15YTImmunologicYTToleranceYTandYTAutoimmunity 62
ChapterYT16YTImmunityYTtoYTMicrobes 67
ChapterYT17YTTransplantationYTImmunology 72
ChapterYT18YTTumorYTImmunology 77
ChapterYT19YTHypersensitivityYTDisorders 81
ChapterYT20YTAllergy 86
ChapterYT21YTPrimaryYTandYTAcquiredYT Immunodeficiencies 89
,Chapter 01: Properties and Overview of Immune Responses
YT YT YT YT YT YT YT
Abbas, Lichtman, and Pillai: Cellular and Molecular Immunology, 10th Edition
YT YT YT YT YT YT YT YT YT
MULTIPLEYTCHOICE
1. TheYTprincipalYTfunctionYTofYTtheYTimmuneYTsystemYTis:
a. DefenseYTagainstYTcancer
b. RepairYTofYTinjuredYTtissues
c. DefenseYTagainstYTmicrobialYTinfections
d. PreventionYTofYTinflammatoryYTdiseases
e. ProtectionYTagainstYTenvironmentalYTtoxins
ANS:Y T C
TheYTimmuneYTsystemYThasYTevolvedYTinYTtheYTsettingYTofYTselectiveYTpressuresYTimposedYTbyYT
microbialYTinfections.YTAlthoughYTimmuneYTresponsesYTtoYTcancerYTmayYToccur,YTtheYTconcept
YTthatYT“immunosurveillance”YTagainstYTcancerYTisYTaYTprincipalYTfunctionYTofYTtheYTimmuneYTs
ystemYTisYTcontroversial.YTRepairYTofYTinjuredYTtissuesYTmayYTbeYTaYTsecondaryYTconsequenceYT
ofYTtheYTimmuneYTresponsesYTandYTinflammation.YTAlthoughYTtheYTimmuneYTsystemYThasYTregu
latoryYTfeaturesYTthatYTareYTneededYTtoYTpreventYTexcessiveYTinflammation,YTpreventionYTofYTinf
lammatoryYTdiseasesYTisYTnotYTaYTprimaryYTfunction.YTTheYTimmuneYTsystemYTcanYTprotectYTagai
nstYTmicrobialYTtoxins,YTbutYTitYTgenerallyYTdoesYTnotYTofferYTprotectionYTagainstYTtoxinsYTofYTno
nbiologicYTorigin.
2. WhichYTofYTtheYTfollowingYTinfectiousYTdiseasesYTwasYTpreventedYTbyYTtheYTfirstYTsu
ccessfulYTvaccination?
a. Polio
b. Tuberculosis
c. Smallpox
d. Tetanus
e. Rubella
ANS:Y T C
InYT1798,YTEdwardYTJennerYTreportedYTtheYTfirstYTintentionalYTsuccessfulYTvaccination,YTwhichY
TwasYTagainstYTsmallpoxYTinYTaYTboy,YTusingYTmaterialYTfromYTtheYTcowpoxYTpustulesYTofYTaYTmilk
maid.YTInYT1980,YTsmallpoxYTwasYTreportedYTtoYTbeYTeradicatedYTworldwideYTbyYTaYTvaccination
YTprogram.YTEffectiveYTvaccinesYTagainstYTtetanusYTtoxin,YTrubellaYTvirus,YTandYTpoliovirusYTwe
reYTdevelopedYTinYTtheYT20thYTcenturyYTandYTareYTwidelyYTused.YTThereYTisYTnoYTeffectiveYTvacci
neYTagainstYTMycobacteriumYTtuberculosis.
3. WhichYTofYTtheYTfollowingYTisYTaYTuniqueYTpropertyYTofYTtheYTadaptiveYTimmuneYTsystem?
a. HighlyYTdiverseYTrepertoireYTofYTspecificitiesYTforYTantigens
b. Self-nonselfYTdiscrimination
c. RecognitionYTofYTmicrobialYTstructuresYTbyYTbothYTcell-associatedYTandYTsolubleYTreceptors
d. ProtectionYTagainstYTviralYTinfections
e. ResponsesYTthatYThaveYTtheYTsameYTkineticsYTandYTmagnitudeYTonYTrepeatedYTexposur
eYTtoYTtheYTsameYTmicrobe
ANS:Y T A
, HighlyYTdiverseYTrepertoiresYTofYTspecificitiesYTforYTantigensYTareYTfoundYTonlyYTinYTTYTandYTBYT
lymphocytes,YTwhichYTareYTtheYTcentralYTcellularYTcomponentsYTofYTtheYTadaptiveYTimmuneYTsy
stem.YTBothYTtheYTinnateYTandYTtheYTadaptiveYTimmuneYTsystemsYTuseYTcell-
associatedYTandYTsolubleYTreceptorsYTtoYTrecognizeYTmicrobes,YTdisplayYTsomeYTdegreeYTofYTself
-
nonselfYTdiscrimination,YTandYTprotectYTagainstYTviruses.YTOnYTrepeatedYTexposureYTtoYTtheYTsa
meYTmicrobe,YTtheYTadaptiveYTimmuneYTresponseYTbecomesYTmoreYTrapidYTandYTofYTgreaterYTma
gnitude;YTthisYTisYTtheYTmanifestationYTofYTmemory.
4. AntibodiesYTandYTTYTlymphocytesYTareYTtheYTrespectiveYTmediatorsYTofYTwhichYTtwoYTt
ypesYTofYTimmunity?
a. InnateYTandYTadaptive
b. PassiveYTandYTactive
c. SpecificYTandYTnonspecific
d. HumoralYTandYTcell-mediated
e. AdultYTandYTneonatal
ANS:Y T D
BothYTBYTandYTTYTlymphocytesYTareYTprincipalYTcomponentsYTofYTadaptiveYTimmunity.YTBYTlymp
hocytesYTproduceYTantibodies,YTwhichYTareYTtheYTrecognitionYTandYTeffectorYTmoleculesYTofYThu
moralYTimmuneYTresponsesYTtoYTextracellularYTpathogens.YTTYTcellsYTrecognizeYTandYTpromoteYT
eradicationYTofYTintracellularYTpathogensYTinYTcell-
mediatedYTimmunity.YTPassiveYTandYTactiveYTimmunityYTbothYTcanYTbeYTmediatedYTbyYTeitherYTBYT
orYTTYTlymphocytes.YTSpecificYTimmunityYTisYTanotherYTtermYTforYTadaptiveYTimmunity.YTBothYTB
YTandYTTYTlymphocytesYTparticipateYTinYTadultYTadaptiveYTimmunityYTbutYTareYTstillYTdevelopingYT
inYTtheYTneonatalYTperiod.
5. TheYTtwoYTmajorYTfunctionalYTclassesYTofYTeffectorYTTYTlymphocytesYTare:
a. HelperYTTYTlymphocytesYTandYTcytotoxicYTTYTlymphocytes
b. NaturalYTkillerYTcellsYTandYTcytoWtoWxW
ic.TTlB
yS
mMph.oW
cyStes
c. MemoryYTTYTcellsYTandYTeffectorYTTYTcells
d. HelperYTcellsYTandYTantigen-presentingYTcells
e. CytotoxicYTTYTlymphocytesYTandYTtargetYTcells
ANS:Y T A
TYTcellsYTcanYTbeYTclassifiedYTintoYTeffectorYTsubsetsYTthatYTperformYTdifferentYTeffectorYTfunctio
ns.YTMostYTeffectorYTTYTcellsYTareYTeitherYThelperYTTYTlymphocytes,YTwhichYTenhanceYTtheYTresp
onsesYTofYTotherYTimmuneYTcells,YTincludingYTphagocytesYTandYTBYTcells,YTtoYTinfections,YTorYTc
ytotoxicYTTYTlymphocytes,YTwhichYTdirectlyYTkillYTinfectedYTcells.YTNaturalYTkillerYTcellsYTareYT
notYTTYTlymphocytes.
Antigen-
presentingYTcellsYTusuallyYTareYTnotYTTYTcells.YTMemoryYTTYTcellsYTareYTnotYTeffectorYTTYTcells.
6. WhichYTofYTtheYTfollowingYTcellYTtypesYTisYTrequiredYTforYTallYTadaptiveYThumoralYTimmuneYTresponse
s?
a. NaturalYTkillerYTcells
b. DendriticYTcells
c. CytolyticYTTYTlymphocytes
d. BYTlymphocytes
e. HelperYTTYTlymphocytes
ANS:Y T D
HumoralYTimmuneYTresponsesYTareYTantibody-
mediatedYTimmuneYTresponses,YTandYTallYTantibodiesYTareYTmadeYTbyYTBYTlymphocytesYTandYT
