(Neuropharmacologic drugs)
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5 steps of synaptic transmission - CORRECT ANSWER-1. transmitter synthesis
2. transmitter storage
3. transmitter release
4. receptor binding
5. termination of transmission (followed by degradation or reuptake)
more receptor types = ________ selectivity - CORRECT ANSWER-increased
local anesthetics ______ axonal conduction - CORRECT ANSWER-supress
PNS (peripheral nervous system) divisions - CORRECT ANSWER-somatic
nervous system and autonomic nervous system
Autonomic nervous system divisions - CORRECT ANSWER-sympathetic and
parasympathetic
,Parasympathetic receptor subtypes - CORRECT ANSWER-Nicotinic N and
muscarinic (cholinergic)
sympathetic receptor subtypes - CORRECT ANSWER-alpha 1 & 2, beta 1 & 2,
and dopamine (adrenergic)
somatic nervous system receptor subtypes - CORRECT ANSWER-Nicotinic M
(cholinergic)
Activation of cholinergic receptor subtypes: Muscarinic - CORRECT ANSWER--
eye: focuses lens for near vision & pupil constriction
- Heart: decreases HR
- Lungs: constriction of bronchi, & promotes secretions
- Bladder: promotes contraction of detrusor & relaxation of trigone and sphincter
(urination)
- GI: increases salvation, secretions, intestinal tone and motility, defecation
Sweat glands: Sweating
Sex organs: erection
BV: Vasodilation
Activation of cholinergic receptor subtypes: Nicotinic N - CORRECT ANSWER--
postganglionic cell bodies: stimulates parasympathetic and sympathetic
postganglionic neurons
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, -adrenal medulla: stimulates release of Epi
Activation of cholinergic receptor subtypes: Nicotinic M - CORRECT ANSWER-
stimulates contraction of skeletal muscle
Activation of adrenergic receptor subtypes: Alpha 1 - CORRECT ANSWER-- eye:
pupil dilation (mydriasis)
- BV of skin, viscera, mucous membranes: vasoconstriction
- Sex organs: ejaculation, prostatic capsule constriction
- Bladder: contraction of trigone and sphincter
Activation of adrenergic receptor subtypes: Alpha 2 - CORRECT ANSWER--
presynaptic nerve terminals: inhibits neurotransmitter release (more clinically
significant in CNS)
Activation of adrenergic receptor subtypes: Beta 1 - CORRECT ANSWER--
Heart: Increased HR, force of contraction, and AV conduction velocity
- Kidneys: stimulates release of renin
Activation of adrenergic receptor subtypes: Beta 2 - CORRECT ANSWER-- BV
of heart, lungs, and skeletal muscles: vasodilation
- Lungs: Bronchodilation
- Uterus: relaxation
- Liver: glycogenolysis